Indianapolis Colts (8-4) at Jacksonville Jaguars (8-4). From EverBank Stadium. NFL rushing leader Jonathan Taylor of Indy faces a top-ranked Jaguars run defense in this pivotal showdown for the AFC South lead. The Colts have remarkably not won in Jacksonville since 2014 (behind QB Andrew Luck), a 10-game drought. Former Penn State teammates Tyler Warren and Brenton Strange are emerging tight ends.