Houston Texans (6-5) at Indianapolis Colts (8-3). From Lucas Oil Stadium. The Colts' quest for their first AFC South title in 11 years begins a challenging stretch run featuring two games each against Houston and Jacksonville (plus the Seahawks and 49ers). NFL rushing leader Jonathan Taylor (held to 58 yards last week) faces Will Anderson Jr. and a sturdy Texans defense that has fueled a 3-0 run.