Jacksonville Jaguars (11-4) at Indianapolis Colts (8-7). From Lucas Oil Stadium. First-year coach Liam Coen's AFC South-leading Jags go for a season sweep that would extend the Colts' playoff drought to five years, just weeks after a flying start had Indy in charge of the division. Devin Lloyd leads the Jacksonville defense against RB Jonathan Taylor. The home team is on a 22-3 run in the series.