Trivia: For better or worse, leading actor Kelsey Grammer's name will probably forever be associated with the pompous, garrulous, and self-absorbed but lovable psychiatrist Frasier Crane, a character Grammer has played on television since he first appeared on the NBC sitcom Cheers, in 1984, as a love interest for Shelley Long. Though Frasier was not intended to become a series regular, Grammer's performance of the blowhard neurotic charmed audiences and he remained with Cheers through its 1993 demise. At the beginning of the 1993-1994 television season, Grammer's character was resurrected in his own show and moved from Boston to Seattle, where he became a radio psychologist and faced a whole slew of folks just waiting to poke metaphorical pins in his hot air balloon. Thanks to excellent performances and top-notch writing, Frasier became as big a hit as its predecessor. Grammer won three Emmy awards and was nominated for seven more (twice for Cheers, once for his guest appearance on a 1992 episode of Wings, four times for Frasier) for playing the character. Born on St. Thomas, one of the U.S. Virgin Islands, Grammer knew extreme tragedy in youth. Following the shooting death of his father when he was a boy, he was raised in New Jersey and then Florida, by his mother and grandfather. His grandfather died before Grammer became a teen. When he was 20, his sister was abducted and violently murdered. Five years later, he lost two half brothers in a diving accident. As a young man, Grammer found comfort in Shakespeare; with his acting debut in a high school production of The Little Foxes came an interest in pursuing drama as a career. He enrolled in Juilliard, but dropped out after two years to work at San Diego's Old Globe Theater, where he gained three years' invaluable experience performing in Shakespearean and classical dramas; afterward, Grammer performed in productions across the country. He eventually made it to Broadway, where he appeared in various productions, including Othello. Prior to playing Frasier, Grammer appeared occasionally on television and had regular roles in three soap operas, including One Life to Live. He continues to occasionally guest star on other series. Fans of the animated satire The Simpsons will recognize his periodic voice characterization as the venomous Sideshow Bob. Miniseries and telemovies in which he has appeared include London Suite and Beyond Suspicion. Grammer made his feature film debut with a small role in Top of the Hill (1989) and had his first starring role in the much-panned comedy Down Periscope (1996). In addition to his Emmy kudos, Grammer has received an American Comedy Award, two Golden Globes, and a People's Choice Award. In 1995, he published his autobiography So Far.Grammer would spend the following years taking on TV roles on shows like Back to You and Boss, but would find even more success as a producer, helping bring shows like The Game, Girlfriends, Hank, Medium, and World Cup Comedy to fruition. In 2014, he returned to acting in a big way, making a cameo appearance in X-Men: Days of Future Past, reprising his role as Beast, playing the bad guy in Transformers: Age of Extinction, and returning to television in the FX series Partners.

Trivia: Although he is best known for his role as anal-retentive psychiatrist extraordinaire Niles Crane on the celebrated sitcom Frasier, David Hyde Pierce has also done considerable work on the stage and screen. Fair, birdlike, and bearing an uncanny resemblance to Frasier co-star Kelsey Grammer, Pierce is one of the entertainment business' finest purveyors of a certain kind of blue-blooded neuroticism, and, in the eyes of some viewers, has even gone so far as to make insecurity perversely sexy.Born in Saratoga Springs, New York, on April 3, 1959, Pierce was raised in what he has described as a "very run-of-the-mill, middle-class" household. When he was eight, he began taking piano lessons, and he decided to pursue a career as a concert pianist. He continued to train until he got to Yale University, where he realized that he was better suited to the acting profession. Following graduation, Pierce moved to New York and did a brief stint as a tie salesman at Bloomingdale's before being cast in a Broadway play. Although the production was a flop, Pierce continued to work on the stage in New York and Chicago for several years and was eventually cast as a suicidal congressman on the short-lived sitcom The Powers That Be in 1992. His work on the show, coupled with his resemblance to Kelsey Grammer, led to his casting on Frasier the following year.Frasier proved to be the turning point in Pierce's career. His portrayal of Niles, aside from winning him a slew of awards, including an Emmy, also provided a number of opportunities for the actor on the big screen. Pierce, who had been acting sporadically in films since the early '80s, could be seen in supporting roles in such '90s films as Sleepless in Seattle (1993), Nixon (1995), in which he played John Dean, and the animated A Bug's Life (1998), for which he provided the voice of a stick insect.As the first decade of the 21st century opened, Pierce began appearing in more and more feature films, selecting an eclectic array of roles that utitlized his strengths without resorting to rehashing the Niles Crane character. Diverse in their genre and theme, the projects also ranged in their levels of success and acclaim. The 2000 comedy Isn't She Great was an abysmal failure, while the indie films Wet Hot American Summer and Full Frontal both left audiences and critics fiercely split. Pierce also continued to flex his voice skills in the animated features Osmosis Jones and Treasure Planet.One of Pierce's best-received roles came in 2003, when he costarred in the tongue-in-cheek comedy Down With Love. While not much of a box-office hit, the film managed to charm many critics with its wall-to-wall homages to 1960s sex-comedies. A year later, Pierce again showed up sans-body, providing the voice of Abe Sapien in the comic-book adaptation Hellboy. He reunited with Hellboy creator Mike Mignola's animated comic adaptation The Amazing Screw-On Head to voice the role of the dreaded Emperor Zombie in 2006, and joined the cast of The Perfect Host in 2010 for a leading role as Warwick Wilson, whose genteel façade hides a deep rage and mental instability.

Trivia: A distinctive-looking, grey-haired British character actor, John Mahoney worked onstage in his teens, and moved to the U.S. at 19. In his mid-30s, while employed as an editor in Chicago, he decided to renew his interest in acting, and he enrolled in classes at a local theater co-founded by playwright David Mamet; he landed a role in a Mamet play and left his job for the part. At the urging of actor John Malkovich, he went on to join Chicago's celebrated Steppenwolf Theater; eventually he appeared in more than 30 plays. For his work in the Broadway play House of Blue Leaves he won a Tony and a Clarence Derwent Award. For his work in the lead role of Orphans (on Broadway and in Chicago) he won a Theater World Award. He still lives in Chicago, and maintains his connection with Steppenwolf. Mahoney debuted onscreen in Mission HIll (1982), but his screen breakthrough came in his fifth film, Barry Levinson's popular comedy Tin Men (1987); afterwards he went on to better parts in more noteworthy movies, and has avoided typecasting in a busy screen career. Mahoney's TV credits include Favorite Son and House of Blue Leaves, in which he reprised his stage role; he has since achieved wide popularity as Martin Crane, Frasier Crane's crochety father, on the NBC sitcom Frasier.

Trivia: Began studying ballet at a very early age, but hurt her ankle when she was 18 and was forced to give it up. Appeared in David Lee Roth's video for "California Girls." Lived for a time with her best friend Faith Ford, whom she met in acting class. Cofounded the production company Bristol Cities with Frasier costar Peri Gilpin in 1998. Since her first pregnancy wasn't written into Frasier, her character, Daphne, was sent off to a fat camp and was said to have lost 9 pounds, 12 ounces---the weight of Jane's daughter when she was born. Made her Broadway debut in Cabaret as Sally Bowles in 2002. Reunited with Fraiser alum Wendy Malick to costar in the TV Land sitcom Hot in Cleveland.

Trivia: With a father who was a famous local radio and television celebrity, a model mother who appeared in television, and a working relationship with Wings producer Roz Doyle in her past, it may all seem like an obscure cosmic joke that pretty Peri Gilpin would rise to fame as radio producer Roz Doyle on the smash television sitcom Frasier, though the longtime actress would likely credit her success to hard work rather than astrological coincidence.Born in Waco, TX, and raised in Dallas, Gilpin began acting on stage with the Dallas Theater Company at the age of eight, a fact that helped her shake stage fright and gain the confidence that would accompany her through numerous future auditions. A Skyline High School graduate, Gilpin later studied acting at both the University of Texas at Austin and London's British-American Academy. Upon returning to the U.S., Gilpin worked as a makeup artist in the Dallas area before taking an apprenticeship with the Williamstown Theater Festival. A chance meeting with actress Blythe Danner resulted in Gilpin gaining some support within the industry, and it wasn't long before Gilpin's dreams were coming true with roles on television's Flesh 'n' Blood and 21 Jump Street. A role on Cheers followed shortly after, and when a spin-off series entitled Frasier became an unexpected hit, Gilpin found the role that would bring her into households across the country on a weekly basis. Appearing frequently on such made-for-television films as The Secret She Carried (1996) and Laughter on the 23rd Floor (2000) while simultaneously essaying her role on Frasier, Gilpin (who was named after the animated Disney character Peri the squirrel) has also loaned her voice to such animated projects as television's Hercules and the computer-animated feature Final Fantasy: The Spirits Within (2001). Throughout the 2000's and 2010's, Gilpin remained active, starring most notably on the dance series Make It or Break It.

Trivia: The oldest of three sons of Broadway star Alan Arkin, American actor Adam Arkin has had stage and movie work, but is best known for his TV assignments. In 1977 Arkin was starred in his first series, the one-season sitcom Bustin' Loose, wherein the 21-year-old actor played a man finally escaping his overprotective parents. Arkin went on to play an inner-city biology teacher in the brief 1982 TV series Teachers Only; a Chicago bookie in the short-lived 1986 weekly Tough Cookies; and an attorney in 1988's A Year in the Life, which lasted eight months of our lives. In 1990, just when it seemed as though Arkin was going to become the King of Cancellation, he made the first of many guest appearances on the quirky CBS series Northern Exposure as Adam, the sociopathic, in-your-face hermit/gourmet chef. The character reappeared sporadically until 1993, sometimes as a welcome touch of anarchy, other times as merely a loud-mouthed royal pain. In 1994, Adam Arkin was given his most recent crack at regular weekly series work, playing a dedicated but mercurial doctor on the TV drama Chicago Hope, where he was matched insult for insult by the equally obstreperous Mandy Patinkin. Though that well-regarded series came to a close in 2000, Arkin continued to work steadily in both movies and TV appearing in a diverse string of projects including A Slight Case of Murder, the sitcom Baby Bob, and the Will Smith vehicle Hitch. He had a major part on the short-lived TV series Life starting in 2007, and in 2009 appeared in the Coen Brothers Best Picture nominee A Serious Man. He also maintained a steady career as a director of series television helming episodes of Monk, Ally McBeal, and Grey's Anatomy. In 2012 he could be seen in The Sessions, a film that won the audience award at the 2012 Sundance Film Festival.

Trivia: Noted producer and screenwriter Larry Gelbart was best known for his television work, but he also penned the scripts for several humorous films. He started out as a radio comic and at age 16 began writing material for Danny Thomas on Fanny Brice's radio show. Before going to television in 1952, he also wrote for Eddie Cantor, Bob Hope, and Jack Parr. On television Gelbart got his start on the Red Buttons Show then went on to work with some of America's greatest comedy writers, including Mel Brooks, Carl Reiner, Neil Simon and Woody Allen on Your Show of Shows. In 1962, Gelbart penned his first screenplay The Notorious Landlady, but his best-known screenplay from that era is A Funny Thing Happened on the Way to the Forum, on which he collaborated with Burt Shevelove. He also wrote the screenplay for Oh, God! (1977) and the smash hit Tootsie (1982). Gelbart was probably best known, however, as the producer and frequent writer for the long-running and highly distinguished comedy-drama M*A*S*H.

Trivia: One of the most talented -- and often underappreciated -- character actresses of the late 1990s, Allison Janney first began courting critical attention with roles in such acclaimed films as Big Night (1996) and American Beauty (1998). Able to play characters ranging from a name-dropping Manhattan socialite to a withdrawn, abused wife, the 6'0" Janney infuses all of her portrayals with equal parts poignancy and unforced gusto.A product of Dayton, Ohio, where she was born November 19, 1959, Janney was raised as the daughter of a homemaker and the president of a real estate firm. She aspired to be a champion figure skater from a young age, but any hopes of pursuing a skating career were halted by a freak accident that badly damaged Janney's leg when she was in her mid-teens. As a student at Kenyon College, she became interested in acting, and got her first break when she successfully auditioned for a play being directed by Kenyon alum Paul Newman. After impressing Newman, a racing enthusiast, with both her acting skills and her love of fast cars, Janney went on to impress his wife, Joanne Woodward, who directed her in a number of off-off-Broadway plays during the early 1980s.Although she enjoyed early stage success, Janney had difficulty starting her career, something that was hindered by her height: one disparaging casting agent went so far as to tell her that the only roles she was suitable for were lesbians and aliens. Thankfully, the actress pressed on in the face of such idiocy, waitressing and scooping ice cream to support herself during dry spells. Her luck began to change for the better in the late 1990s, when she started garnering luminous reviews for her work both on Broadway -- where she earned a Tony nomination for her role in 1998's A View from the Bridge -- and onscreen in such films as Big Night (1996) and Mike Nichols' Primary Colors (1998). In the former film, she appeared as the quiet, capable love interest of Tony Shalhoub's struggling Italian chef, while the latter featured the actress in the minor but poignant role of a painfully-awkward schoolteacher who is seduced by John Travolta's libidinous Presidential candidate. Janney, who had been appearing on television and in films since the early '90s, went on to do reliably excellent work in a variety of films that ranged from The Object of My Affection (1998), in which she played the supercilious, name-dropping wife of a high-powered literary agent (Alan Alda); to Drop Dead Gorgeous (1999), which featured her as a beehived, chain-smoking trailer park resident; to American Beauty (1999), in which she gave a quietly powerful portrayal of the abused wife of a tyrannical ex-Marine (Chris Cooper). Janney's talents have also been put on ample display on the small screen: in 1999, she joined the cast of the acclaimed NBC White House drama The West Wing, originating the role of tough press secretary C.J. Cregg.In addition to continuing her work on The West Wing, Janney played a supporting role in the award winning psychological drama The Hours (2002), and voiced Peach the Starfish in Pixar's wildly successful Finding Nemo (2003). The actress' would play the neighbor of protagonist Jim Winters (Anthony LaPaglia) in 2004's drama Winter Solstice, and continued to play small, yet meaty roles throughout the coming years (among them include On Our Very Own and Hairspray), she earned mainstream attention and critical praise for her role as the parent of a pregnant teen (Ellen Page) in Juno. Ironically, in light of her Juno success, Janney was also critically recognized for her performance as an emotionally detached mother in Sam Mendes' bittersweet comedy Away We Go (2009).

Trivia: A professional actor since the age of nine, Jennifer Jason Leigh earned her Screen Actors Guild card at 16 and dropped out of high school to study at the Lee Strasberg Institute and star in seedy made-for-TV movies. Born to actor Vic Morrow and writer/actress Barbara Turner in Hollywood, CA, Jennifer picked up the middle name Jason from family friend Jason Robards Jr. Throughout her career, she has made a name for herself portraying helpless, damaged, or mentally unsound characters, often performing at a higher level than the material. Also known for extensively researching her roles, Leigh dropped down to less than 90 pounds for one of her first features as an anorexic teenager in the TV-movie The Best Little Girl in the World. Never one to shy away from touchy subject matter, her breakthrough role came in 1982 as the naïve high school girl who gets an abortion in Fast Times at Ridgemont High. After a decade of developing a repertoire of various troubled characters, she was nominated for two Critics Circle awards in 1990 for playing prostitutes in both Miami Blues and Last Exit to Brooklyn. She would continue to play vulnerable characters in dangerous situations as the rookie narcotics officer-turned-drug addict in Rush. This was followed by her notorious role as the psycho roommate Hedra who tries to steal the identity of her roommate (Bridget Fonda) in Single White Female. She played a phone sex worker in the ensemble film Short Cuts, her first of three projects involving director Robert Altman. Leigh occasionally stepped out of her down-and-out roles, and in 1994 she shined as Amy Archer in The Hudsucker Proxy. Her comic turn as a plucky undercover journalist was said to recall the work of legendary actresses like Katharine Hepburn and Barbara Stanwyck. She delivered critically acclaimed performances in her next two films, with a Golden Globe nomination for Mrs. Parker and the Vicious Circle and an Independent Spirit nomination for Georgia. After playing an angry daughter in Dolores Claiborne, a spitfire kidnapper in Kansas City, and a domestic violence survivor in Bastard out of Carolina, she took another dramatic turn toward a period film. In Agnieszka Holland's Washington Square, Leigh proved her range by portraying a shy, clumsy girl as she evolves into adulthood. She returned to more showy roles for two films dealing with Shakespeare's King Lear: A Thousand Acres with Jason Robards Jr. and the fourth Dogme 95 film, The King Is Alive. Not limiting herself to dramas, Leigh appeared as an isolated computer programmer in David Cronenberg's thriller eXistenZ and as an over-the-top mom in the comedy Skipped Parts. Around that time, she also appeared on-stage in Broadway and off-Broadway plays, most notably as dancer Sally Bowles in Cabaret. Testing out new ground in 2001, she and fellow Cabaret star Alan Cumming wrote, directed, and starred in the ensemble comedy The Anniversary Party, a digital video project inspired by Dogme 95. Continuing to evolve as a respected actress, she went on to work in the crime genre, first as a hitman's wife in Road to Perdition, and then in Jane Campion's thriller In the Cut. In the several years to come, Leigh would remain an active force on screen, appearing most memorably in films like Margot at the Wedding, Synecdoche, New York, and on the series Weeds. After several years of quiet films, she made a splash in 2015 with two very different movies - the stop-motion film Anomalisa (directed by Charlie Kaufman and Duke Johnson) and The Hateful Eight, a western homage by Quentin Tarantino. Leigh nabbed an Oscar nomination for her work The Hateful Eight, the first in her career.

Trivia: A black cabaret artist, singer, and pianist, he appeared onscreen in Call Me Mister (1951).