Trivia: For better or worse, leading actor Kelsey Grammer's name will probably forever be associated with the pompous, garrulous, and self-absorbed but lovable psychiatrist Frasier Crane, a character Grammer has played on television since he first appeared on the NBC sitcom Cheers, in 1984, as a love interest for Shelley Long. Though Frasier was not intended to become a series regular, Grammer's performance of the blowhard neurotic charmed audiences and he remained with Cheers through its 1993 demise. At the beginning of the 1993-1994 television season, Grammer's character was resurrected in his own show and moved from Boston to Seattle, where he became a radio psychologist and faced a whole slew of folks just waiting to poke metaphorical pins in his hot air balloon. Thanks to excellent performances and top-notch writing, Frasier became as big a hit as its predecessor. Grammer won three Emmy awards and was nominated for seven more (twice for Cheers, once for his guest appearance on a 1992 episode of Wings, four times for Frasier) for playing the character. Born on St. Thomas, one of the U.S. Virgin Islands, Grammer knew extreme tragedy in youth. Following the shooting death of his father when he was a boy, he was raised in New Jersey and then Florida, by his mother and grandfather. His grandfather died before Grammer became a teen. When he was 20, his sister was abducted and violently murdered. Five years later, he lost two half brothers in a diving accident. As a young man, Grammer found comfort in Shakespeare; with his acting debut in a high school production of The Little Foxes came an interest in pursuing drama as a career. He enrolled in Juilliard, but dropped out after two years to work at San Diego's Old Globe Theater, where he gained three years' invaluable experience performing in Shakespearean and classical dramas; afterward, Grammer performed in productions across the country. He eventually made it to Broadway, where he appeared in various productions, including Othello. Prior to playing Frasier, Grammer appeared occasionally on television and had regular roles in three soap operas, including One Life to Live. He continues to occasionally guest star on other series. Fans of the animated satire The Simpsons will recognize his periodic voice characterization as the venomous Sideshow Bob. Miniseries and telemovies in which he has appeared include London Suite and Beyond Suspicion. Grammer made his feature film debut with a small role in Top of the Hill (1989) and had his first starring role in the much-panned comedy Down Periscope (1996). In addition to his Emmy kudos, Grammer has received an American Comedy Award, two Golden Globes, and a People's Choice Award. In 1995, he published his autobiography So Far.Grammer would spend the following years taking on TV roles on shows like Back to You and Boss, but would find even more success as a producer, helping bring shows like The Game, Girlfriends, Hank, Medium, and World Cup Comedy to fruition. In 2014, he returned to acting in a big way, making a cameo appearance in X-Men: Days of Future Past, reprising his role as Beast, playing the bad guy in Transformers: Age of Extinction, and returning to television in the FX series Partners.

Trivia: Although he is best known for his role as anal-retentive psychiatrist extraordinaire Niles Crane on the celebrated sitcom Frasier, David Hyde Pierce has also done considerable work on the stage and screen. Fair, birdlike, and bearing an uncanny resemblance to Frasier co-star Kelsey Grammer, Pierce is one of the entertainment business' finest purveyors of a certain kind of blue-blooded neuroticism, and, in the eyes of some viewers, has even gone so far as to make insecurity perversely sexy.Born in Saratoga Springs, New York, on April 3, 1959, Pierce was raised in what he has described as a "very run-of-the-mill, middle-class" household. When he was eight, he began taking piano lessons, and he decided to pursue a career as a concert pianist. He continued to train until he got to Yale University, where he realized that he was better suited to the acting profession. Following graduation, Pierce moved to New York and did a brief stint as a tie salesman at Bloomingdale's before being cast in a Broadway play. Although the production was a flop, Pierce continued to work on the stage in New York and Chicago for several years and was eventually cast as a suicidal congressman on the short-lived sitcom The Powers That Be in 1992. His work on the show, coupled with his resemblance to Kelsey Grammer, led to his casting on Frasier the following year.Frasier proved to be the turning point in Pierce's career. His portrayal of Niles, aside from winning him a slew of awards, including an Emmy, also provided a number of opportunities for the actor on the big screen. Pierce, who had been acting sporadically in films since the early '80s, could be seen in supporting roles in such '90s films as Sleepless in Seattle (1993), Nixon (1995), in which he played John Dean, and the animated A Bug's Life (1998), for which he provided the voice of a stick insect.As the first decade of the 21st century opened, Pierce began appearing in more and more feature films, selecting an eclectic array of roles that utitlized his strengths without resorting to rehashing the Niles Crane character. Diverse in their genre and theme, the projects also ranged in their levels of success and acclaim. The 2000 comedy Isn't She Great was an abysmal failure, while the indie films Wet Hot American Summer and Full Frontal both left audiences and critics fiercely split. Pierce also continued to flex his voice skills in the animated features Osmosis Jones and Treasure Planet.One of Pierce's best-received roles came in 2003, when he costarred in the tongue-in-cheek comedy Down With Love. While not much of a box-office hit, the film managed to charm many critics with its wall-to-wall homages to 1960s sex-comedies. A year later, Pierce again showed up sans-body, providing the voice of Abe Sapien in the comic-book adaptation Hellboy. He reunited with Hellboy creator Mike Mignola's animated comic adaptation The Amazing Screw-On Head to voice the role of the dreaded Emperor Zombie in 2006, and joined the cast of The Perfect Host in 2010 for a leading role as Warwick Wilson, whose genteel façade hides a deep rage and mental instability.

Trivia: A distinctive-looking, grey-haired British character actor, John Mahoney worked onstage in his teens, and moved to the U.S. at 19. In his mid-30s, while employed as an editor in Chicago, he decided to renew his interest in acting, and he enrolled in classes at a local theater co-founded by playwright David Mamet; he landed a role in a Mamet play and left his job for the part. At the urging of actor John Malkovich, he went on to join Chicago's celebrated Steppenwolf Theater; eventually he appeared in more than 30 plays. For his work in the Broadway play House of Blue Leaves he won a Tony and a Clarence Derwent Award. For his work in the lead role of Orphans (on Broadway and in Chicago) he won a Theater World Award. He still lives in Chicago, and maintains his connection with Steppenwolf. Mahoney debuted onscreen in Mission HIll (1982), but his screen breakthrough came in his fifth film, Barry Levinson's popular comedy Tin Men (1987); afterwards he went on to better parts in more noteworthy movies, and has avoided typecasting in a busy screen career. Mahoney's TV credits include Favorite Son and House of Blue Leaves, in which he reprised his stage role; he has since achieved wide popularity as Martin Crane, Frasier Crane's crochety father, on the NBC sitcom Frasier.

Trivia: Began studying ballet at a very early age, but hurt her ankle when she was 18 and was forced to give it up. Appeared in David Lee Roth's video for "California Girls." Lived for a time with her best friend Faith Ford, whom she met in acting class. Cofounded the production company Bristol Cities with Frasier costar Peri Gilpin in 1998. Since her first pregnancy wasn't written into Frasier, her character, Daphne, was sent off to a fat camp and was said to have lost 9 pounds, 12 ounces---the weight of Jane's daughter when she was born. Made her Broadway debut in Cabaret as Sally Bowles in 2002. Reunited with Fraiser alum Wendy Malick to costar in the TV Land sitcom Hot in Cleveland.

Trivia: With a father who was a famous local radio and television celebrity, a model mother who appeared in television, and a working relationship with Wings producer Roz Doyle in her past, it may all seem like an obscure cosmic joke that pretty Peri Gilpin would rise to fame as radio producer Roz Doyle on the smash television sitcom Frasier, though the longtime actress would likely credit her success to hard work rather than astrological coincidence.Born in Waco, TX, and raised in Dallas, Gilpin began acting on stage with the Dallas Theater Company at the age of eight, a fact that helped her shake stage fright and gain the confidence that would accompany her through numerous future auditions. A Skyline High School graduate, Gilpin later studied acting at both the University of Texas at Austin and London's British-American Academy. Upon returning to the U.S., Gilpin worked as a makeup artist in the Dallas area before taking an apprenticeship with the Williamstown Theater Festival. A chance meeting with actress Blythe Danner resulted in Gilpin gaining some support within the industry, and it wasn't long before Gilpin's dreams were coming true with roles on television's Flesh 'n' Blood and 21 Jump Street. A role on Cheers followed shortly after, and when a spin-off series entitled Frasier became an unexpected hit, Gilpin found the role that would bring her into households across the country on a weekly basis. Appearing frequently on such made-for-television films as The Secret She Carried (1996) and Laughter on the 23rd Floor (2000) while simultaneously essaying her role on Frasier, Gilpin (who was named after the animated Disney character Peri the squirrel) has also loaned her voice to such animated projects as television's Hercules and the computer-animated feature Final Fantasy: The Spirits Within (2001). Throughout the 2000's and 2010's, Gilpin remained active, starring most notably on the dance series Make It or Break It.

Trivia: John McGinley, often credited as John C. McGinley, has become one of the most prolific character actors in Hollywood since he first got noticed in Oliver Stone's Platoon (1986). The intense, unblinking actor specializes in sarcasm, cynicism, and a used car dealer's unctuous insincerity, meaning he can play either wacky or sinister in both comedies and dramas. Although he has appeared in six Stone films, his breakout performance came in a very different format, as the acerbic and piercingly straightforward Dr. Perry Cox on the hit NBC sitcom Scrubs (2001).McGinley was born on August 3, 1959, in New York City. Growing up in Millburn, NJ, he was more involved in sports than theater. He began studying acting at Syracuse University, continuing at N.Y.U.'s Tisch School of the Arts. McGinley then toiled both on and off-Broadway, as well as two years on the soap opera Another World, scoring his first film role in the Alan Alda-directed Sweet Liberty (1986). It was while he was serving as John Turturro's understudy on the play Danny and the Deep Blue Sea that a casting scout in Stone's employ spotted him and got him an audition for Platoon. McGinley was cast as the sycophantic Sgt. Red O'Neill in the eventual Oscar winner.McGinley followed up Platoon with another one-two punch of Stone movies, Wall Street (1987) and Talk Radio (1988). In interviews, McGinley has described theirs as a "strong working relationship," not a friendship per se with the demanding director. He appeared in a handful of other films before his fourth Stone collaboration, Born on the Fourth of July (1989), which was quickly followed by his first screenwriting effort. McGinley co-scripted and co-starred in the 1990 film Suffering Bastards, alongside Talk Radio's Eric Bogosian.The 1990s were a period of intense work for the actor, who appeared in an average of three movies a year, sometimes as many as seven -- a necessary but no less tricky feat for a character actor earning modest paychecks. The most heralded of these were David Fincher's Seven and Stone's Nixon (both 1995); the most forgettable were Highlander II: The Quickening (1991) and the Steven Seagal starrer On Deadly Ground (1994). For most moviegoers, he remained under the radar.Two showy roles in 1999 ably demonstrated McGinley's facility for comedy. As a callous efficiency expert brought aboard to reorganize (i.e., downsize) the tech firm at the heart of Office Space, McGinley grinned and joked his way through a round of heartless layoffs. A similar oiliness informed his loud, obnoxious, kiss-ass portrayal of a Jim Rome-type sports interviewer in Stone's Any Given Sunday. It was soon after, in 2001, that McGinley was brought aboard for the role destined to identify him beyond any single film. As the default mentor on Scrubs, McGinley alternated hard-knocks frankness, biting wit, and a genuine desire to be left alone, in turn creating a hilarious persona and sealing his fate as an unwitting cult figure to the young surgeons. The sitcom work schedule has given him the necessary stability to spend time with his young son, Max, who has Down's syndrome.

Trivia: A character actor whose beefy, imposing build (a magazine once listed him as 6'3" and 245 pounds) typecast him as thugs, hoods, and underworld heavies, performer Mike Starr was raised in the Manhattan area, as the son of a meatpacker and a five-and-dime clerk. He attended Long Island's Hofstra University on a drama scholarship, and -- after graduation -- toiled at menial jobs as a bartender and club bouncer before landing his first film role in William Friedkin's gay-themed cop thriller Cruising (1980). Many projects ensued over the following decades, including The Natural (1984), Uncle Buck (1989, in a memorable bit as a drunken clown), Ed Wood (1994), and Jersey Girl (2004). Fans of the gangster-themed comedy Mad Dog and Glory (1993), in particular, might remember Starr -- he played Harold, the wife-beater husband who gets on David Caruso's bad side, and physically suffers for it. In 2007, Starr essayed a rare lead in the character comedy Osso Bucco; he played a gangster unknowingly targeted for death and due for extermination by his cousin.

Trivia: The most successful child performer since Shirley Temple (Mickey Rooney wasn't a star until his teen years), Macaulay Culkin first stepped onto a New York stage at the age of four. Extensively trained for his craft, including a stint with Balanchine's School of the American Ballet, young Culkin became a familiar TV-commercial face and was spotlighted in several film supporting roles, the best of which was as John Candy's inquisitive nephew in Uncle Buck (1989). After an unbilled cameo in Jacob's Ladder (1990) and prior to an appearance in a Michael Jackson video, Culkin was cast as the preteen protagonist of Home Alone, a Three Stooges-like combination of violent slapstick and sappy sentiment that was the highest-grossing film of 1990. Culkin thereby became the highest paid child actor of all time, and one of the few under-13 performers who could be counted on to "open" a picture. Two more blockbusters followed: My Girl (1991) and Home Alone 2: Lost in New York (1992). At the time, the boy's career was under the tight control of his father Christopher "Kit" Culkin, an erstwhile actor who also managed the careers of Culkin's younger, equally photogenic siblings, and stories began to emerge from Hollywood concerning the elder Culkin's on-set behavior. Meanwhile, Macaulay's box-office appeal began waning, partly due to indifferent response to his next few films -- The Good Son (1993), Getting Even With Dad (1994), and Richie Rich (1994) -- but chiefly because he was outgrowing his cuteness and spontaneity. In June 1995, Culkin's mother went to court to remove the boy from Kit's custody, insisting that the father's contentiousness was ruining Macaulay's chances of revitalizing his career. At a few months shy of age 18, Culkin married actress Rachel Miner in 1998, but the couple separated in 2000. The former child star re-emerged in 2002 in documentarians Fenton Bailey and Randy Barbato's feature debut, Party Monster, the true-life story of the rise and fall of a young club promoter. He enjoyed a lengthy relationship throughout the 2000s with Mila Kunis.