Indianapolis Colts (8-5) at Seattle Seahawks (10-3). From Lumen Field. Mike Macdonald's Seahawks go for a 4-0 sweep of the AFC South, which had been in Indy's control until a three-game losing streak they bring with them--along with un-retired 44-year-old QB Philip Rivers. The Colts lean on NFL rushing leader Jonathan Taylor, who faces a rugged Seattle front that's fourth in run defense (91 ypg).