San Francisco 49ers (10-4) at Indianapolis Colts (8-6). From Lucas Oil Stadium. Kyle Shanahan's Niners bring a four-game win streak into Indy, where 44-year-old Philip Rivers is again at QB amid a four-game slide in which the Colts have averaged just 260 ypg and 17.8 ppg. Workhorse RBs Christian McCaffrey (14 total TDs) and Jonathan Taylor (18) look to add to their gaudy scoring numbers. The Colts have won the last five meetings, with San Francisco last prevailing in 2001.