San Francisco 49ers at Seattle Seahawks in an NFC Divisional game. From Lumen Field. Kyle Shanahan's 49ers look to avenge their 13-3 loss to NFC West-rival Seattle from just two weeks ago in which the Seahawks rode a stifling defense to take what was a showdown for the NFC's No. 1 seed. San Francisco prevailed 17-13 here in Week 1, with Brock Purdy hitting TE Jake Tonges for a late 4-yard TD. Seattle has won its last 10 home playoff games played in front of fans, losing only in COVID 2020.