Tennessee Titans (2-11) at San Francisco 49ers (9-4). From Levi's Stadium. The Niners come off a much-needed bye week looking to resume a 3-0 run in which DC Robert Saleh's defense collected seven takeaways, with oft-sacked rookie QB Cam Ward piloting Tennessee. Christian McCaffrey and Tony Pollard are workhorse RBs, with the latter coming off a career-high 161-yard game for the Titans.