Trivia: For better or worse, leading actor Kelsey Grammer's name will probably forever be associated with the pompous, garrulous, and self-absorbed but lovable psychiatrist Frasier Crane, a character Grammer has played on television since he first appeared on the NBC sitcom Cheers, in 1984, as a love interest for Shelley Long. Though Frasier was not intended to become a series regular, Grammer's performance of the blowhard neurotic charmed audiences and he remained with Cheers through its 1993 demise. At the beginning of the 1993-1994 television season, Grammer's character was resurrected in his own show and moved from Boston to Seattle, where he became a radio psychologist and faced a whole slew of folks just waiting to poke metaphorical pins in his hot air balloon. Thanks to excellent performances and top-notch writing, Frasier became as big a hit as its predecessor. Grammer won three Emmy awards and was nominated for seven more (twice for Cheers, once for his guest appearance on a 1992 episode of Wings, four times for Frasier) for playing the character. Born on St. Thomas, one of the U.S. Virgin Islands, Grammer knew extreme tragedy in youth. Following the shooting death of his father when he was a boy, he was raised in New Jersey and then Florida, by his mother and grandfather. His grandfather died before Grammer became a teen. When he was 20, his sister was abducted and violently murdered. Five years later, he lost two half brothers in a diving accident. As a young man, Grammer found comfort in Shakespeare; with his acting debut in a high school production of The Little Foxes came an interest in pursuing drama as a career. He enrolled in Juilliard, but dropped out after two years to work at San Diego's Old Globe Theater, where he gained three years' invaluable experience performing in Shakespearean and classical dramas; afterward, Grammer performed in productions across the country. He eventually made it to Broadway, where he appeared in various productions, including Othello. Prior to playing Frasier, Grammer appeared occasionally on television and had regular roles in three soap operas, including One Life to Live. He continues to occasionally guest star on other series. Fans of the animated satire The Simpsons will recognize his periodic voice characterization as the venomous Sideshow Bob. Miniseries and telemovies in which he has appeared include London Suite and Beyond Suspicion. Grammer made his feature film debut with a small role in Top of the Hill (1989) and had his first starring role in the much-panned comedy Down Periscope (1996). In addition to his Emmy kudos, Grammer has received an American Comedy Award, two Golden Globes, and a People's Choice Award. In 1995, he published his autobiography So Far.Grammer would spend the following years taking on TV roles on shows like Back to You and Boss, but would find even more success as a producer, helping bring shows like The Game, Girlfriends, Hank, Medium, and World Cup Comedy to fruition. In 2014, he returned to acting in a big way, making a cameo appearance in X-Men: Days of Future Past, reprising his role as Beast, playing the bad guy in Transformers: Age of Extinction, and returning to television in the FX series Partners.

Trivia: Although he is best known for his role as anal-retentive psychiatrist extraordinaire Niles Crane on the celebrated sitcom Frasier, David Hyde Pierce has also done considerable work on the stage and screen. Fair, birdlike, and bearing an uncanny resemblance to Frasier co-star Kelsey Grammer, Pierce is one of the entertainment business' finest purveyors of a certain kind of blue-blooded neuroticism, and, in the eyes of some viewers, has even gone so far as to make insecurity perversely sexy.Born in Saratoga Springs, New York, on April 3, 1959, Pierce was raised in what he has described as a "very run-of-the-mill, middle-class" household. When he was eight, he began taking piano lessons, and he decided to pursue a career as a concert pianist. He continued to train until he got to Yale University, where he realized that he was better suited to the acting profession. Following graduation, Pierce moved to New York and did a brief stint as a tie salesman at Bloomingdale's before being cast in a Broadway play. Although the production was a flop, Pierce continued to work on the stage in New York and Chicago for several years and was eventually cast as a suicidal congressman on the short-lived sitcom The Powers That Be in 1992. His work on the show, coupled with his resemblance to Kelsey Grammer, led to his casting on Frasier the following year.Frasier proved to be the turning point in Pierce's career. His portrayal of Niles, aside from winning him a slew of awards, including an Emmy, also provided a number of opportunities for the actor on the big screen. Pierce, who had been acting sporadically in films since the early '80s, could be seen in supporting roles in such '90s films as Sleepless in Seattle (1993), Nixon (1995), in which he played John Dean, and the animated A Bug's Life (1998), for which he provided the voice of a stick insect.As the first decade of the 21st century opened, Pierce began appearing in more and more feature films, selecting an eclectic array of roles that utitlized his strengths without resorting to rehashing the Niles Crane character. Diverse in their genre and theme, the projects also ranged in their levels of success and acclaim. The 2000 comedy Isn't She Great was an abysmal failure, while the indie films Wet Hot American Summer and Full Frontal both left audiences and critics fiercely split. Pierce also continued to flex his voice skills in the animated features Osmosis Jones and Treasure Planet.One of Pierce's best-received roles came in 2003, when he costarred in the tongue-in-cheek comedy Down With Love. While not much of a box-office hit, the film managed to charm many critics with its wall-to-wall homages to 1960s sex-comedies. A year later, Pierce again showed up sans-body, providing the voice of Abe Sapien in the comic-book adaptation Hellboy. He reunited with Hellboy creator Mike Mignola's animated comic adaptation The Amazing Screw-On Head to voice the role of the dreaded Emperor Zombie in 2006, and joined the cast of The Perfect Host in 2010 for a leading role as Warwick Wilson, whose genteel façade hides a deep rage and mental instability.

Trivia: A distinctive-looking, grey-haired British character actor, John Mahoney worked onstage in his teens, and moved to the U.S. at 19. In his mid-30s, while employed as an editor in Chicago, he decided to renew his interest in acting, and he enrolled in classes at a local theater co-founded by playwright David Mamet; he landed a role in a Mamet play and left his job for the part. At the urging of actor John Malkovich, he went on to join Chicago's celebrated Steppenwolf Theater; eventually he appeared in more than 30 plays. For his work in the Broadway play House of Blue Leaves he won a Tony and a Clarence Derwent Award. For his work in the lead role of Orphans (on Broadway and in Chicago) he won a Theater World Award. He still lives in Chicago, and maintains his connection with Steppenwolf. Mahoney debuted onscreen in Mission HIll (1982), but his screen breakthrough came in his fifth film, Barry Levinson's popular comedy Tin Men (1987); afterwards he went on to better parts in more noteworthy movies, and has avoided typecasting in a busy screen career. Mahoney's TV credits include Favorite Son and House of Blue Leaves, in which he reprised his stage role; he has since achieved wide popularity as Martin Crane, Frasier Crane's crochety father, on the NBC sitcom Frasier.

Trivia: Began studying ballet at a very early age, but hurt her ankle when she was 18 and was forced to give it up. Appeared in David Lee Roth's video for "California Girls." Lived for a time with her best friend Faith Ford, whom she met in acting class. Cofounded the production company Bristol Cities with Frasier costar Peri Gilpin in 1998. Since her first pregnancy wasn't written into Frasier, her character, Daphne, was sent off to a fat camp and was said to have lost 9 pounds, 12 ounces---the weight of Jane's daughter when she was born. Made her Broadway debut in Cabaret as Sally Bowles in 2002. Reunited with Fraiser alum Wendy Malick to costar in the TV Land sitcom Hot in Cleveland.

Trivia: With a father who was a famous local radio and television celebrity, a model mother who appeared in television, and a working relationship with Wings producer Roz Doyle in her past, it may all seem like an obscure cosmic joke that pretty Peri Gilpin would rise to fame as radio producer Roz Doyle on the smash television sitcom Frasier, though the longtime actress would likely credit her success to hard work rather than astrological coincidence.Born in Waco, TX, and raised in Dallas, Gilpin began acting on stage with the Dallas Theater Company at the age of eight, a fact that helped her shake stage fright and gain the confidence that would accompany her through numerous future auditions. A Skyline High School graduate, Gilpin later studied acting at both the University of Texas at Austin and London's British-American Academy. Upon returning to the U.S., Gilpin worked as a makeup artist in the Dallas area before taking an apprenticeship with the Williamstown Theater Festival. A chance meeting with actress Blythe Danner resulted in Gilpin gaining some support within the industry, and it wasn't long before Gilpin's dreams were coming true with roles on television's Flesh 'n' Blood and 21 Jump Street. A role on Cheers followed shortly after, and when a spin-off series entitled Frasier became an unexpected hit, Gilpin found the role that would bring her into households across the country on a weekly basis. Appearing frequently on such made-for-television films as The Secret She Carried (1996) and Laughter on the 23rd Floor (2000) while simultaneously essaying her role on Frasier, Gilpin (who was named after the animated Disney character Peri the squirrel) has also loaned her voice to such animated projects as television's Hercules and the computer-animated feature Final Fantasy: The Spirits Within (2001). Throughout the 2000's and 2010's, Gilpin remained active, starring most notably on the dance series Make It or Break It.

Trivia: Born in a German refugee camp, actor Saul Rubinek was raised in Canada, where he began his career. After several years of activity with the Toronto Free Theater, the versatile Rubinek headed for New York, where he worked in repertory and on Broadway. Rubinek's performance as the best friend of religious cult member Nick Mancuso in the little-seen Ticket to Heaven (1981) was a critical coup for the actor. A reliable presence in such meaty supporting roles as the Ned Buntline-ish dime novelist in The Unforgiven (1994), and Hollywood producer Lee Donowitz in True Romance, Rubinek would spend the coming decades working steadily in films like I Love Trouble and Nixon, as well as on TV shows like A Nero Wolfe Mystery, Frasier, Blind Justice, and Warehouse 13.

Trivia: Possessing an earthy, natural brunette beauty which allows her to effortlessly shift from glamorous to down-to-earth at the drop of a hat, actress Amy Brenneman first caught the attention of television viewers with her Emmy-nominated performance on the popular television series NYPD Blue. Though she would later gravitate to a feature career with roles in such films as Heat (1995), Daylight (1996), and Your Friends & Neighbors (1998), her television career continued to flourish as she took on the role of a single mother and Family Court judge in Judging Amy. Born the youngest of three children in New London, CT, Brenneman's mother was a superior court judge and her father an environmental attorney while she was growing up in nearby Glastonbury. Her love for acting blossoming in her pre-teen years, Brenneman would later study comparative religion at Harvard University. During her college years, performances with the American Repertoire Theater and the Harvard-Radcliffe Summer Theater found the burgeoning actress honing her skills in the work of such playwrights as Shakespeare and Aeschylus. In addition to acting during college, Brenneman also founded the Cornerstone Theater Company, a traveling troupe dedicated to performing around the country and encouraging locals to participate in the show. Relocating to New York City following a five-year stint with Cornerstone, Brenneman found work as a substitute teacher in Brooklyn while continuing to appear frequently on-stage. Brenneman made her small-screen debut in a 1992 episode of Murder She Wrote, and was soon headlining her own series with that same year's Middle Ages. After her yearlong stint on NYPD Blue it was time to make the leap to the big screen, and following 1995's Bye Bye, Love, Brenneman would go on to appear in features while gradually climbing the credits. With the exception of her leading-lady role in the little-seen Nevada, Brenneman's frequent supporting roles would always manage to stand out no matter how formidable her co-stars' talents. Putting her childhood experiences to creative use in Judging Amy, the show proved an enduring success with its sincere blend of drama and family conflict. Moving into the new millennium, Brenneman essayed the role of artist Mary Cassatt in the made-for-television feature Mary Cassatt: An American Impressionist (1999), and took on substantial roles in the theatrical releases Things You Can Tell Just By Looking at Her (2000) and Off the Map (2003). Brenneman is married to director Brad Silberling, whom she met while working on NYPD Blue. When Judging Amy ended its run in 2004, she had a three year layoff, reappearing in The Jane Austen Book Club, and taking a major part in the Grey's Anatomy spinoff Private Practice. Her small-screen commitments didn't keep her out of movie houses; she was cast in 88 Minutes and Mother and Child.

Trivia: Although she garnered some attention at the outset of her Hollywood career, Virginia Madsen found her star eclipsed in the 1990s by her older brother Michael's jolting, thuggish performances for director Quentin Tarantino. After landing a plum role in the acclaimed 2004 indie Sideways, however, Madsen was showered with the kind of praise she'd been denied for nearly two decades in the business.A native of the Chicago suburbs and the daughter of a PBS documentarian, Madsen learned her trade in city theater productions and summer performance camps. She made her way to Hollywood in the early '80s with her then-fiancé/fellow performer Billy Campbell. Making an inauspicious debut at the age of 19 as Andrew McCarthy's would-be first-time conquest in the teen sex comedy Class, she would go on to more noteworthy roles in director David Lynch's sci-fi epic Dune and the slick but heartfelt romantic comedy Electric Dreams (both 1984). The rest of the decade wouldn't be quite as kind, as Madsen shuffled from part to part, appearing in a supporting capacity in both ambitious arthouse fare (1987's Slamdance) and forgettable Hollywood comedies (1988's Hot to Trot and Mr. North, the latter of which sparked a relationship with -- and three-year marriage to -- director Danny Huston). The beginning of the next decade fared somewhat better for Madsen. After a memorably brassy turn opposite Don Johnson in Dennis Hopper's steamy, seamy The Hot Spot (1990), she raked in some box-office cash in the minor horror hit Candyman (1992). Small performances in the high-profile, prestige pics Ghosts of Mississippi and The Rainmaker notwithstanding, Madsen all but disappeared from the late-'90s feature marketplace, as most of her films were either made for television or delivered directly to video-store rental shelves. Finding a more receptive outlet on weekly TV, Madsen snagged prominent recurring roles on NBC's Frasier and American Dreams around the turn of the century.But it was writer/director Alexander Payne's low-budget character study Sideways that had Madsen clamoring for the ever-elusive "role of a lifetime." Payne was mostly unfamiliar with the actress' work, but her audition for the part of Maya -- a weary, contemplative divorcée with a fine-tuned taste for wine -- convinced him that she was the perfect complement to lead performer Paul Giamatti's high-strung sad sack Miles. Toning down her Hollywood glamour for the film, Madsen turned the small part into something of a revelation, and as reviewers showered praise upon the film in late 2004, the actress hauled in a truckload of awards from critics' groups as well as Golden Globe and Oscar nominations for Best Supporting Actress.Although Madsen lost the Oscar bid to Cate Blanchett, high-profile offers rolled in after her Sideways coup. Early in 2006, she played Beth Stanfield, the wife of Harrison Ford's technology executive Jack Stanfield, in Richard Loncraine's disappointing hostage thriller Firewall; that summer, she also claimed an enigmatic part as a beguiling angel of death in Robert Altman's swan song, A Prairie Home Companion. Madsen began 2007 with two supporting turns in the same February weekend: in Michael Polish's The Astronaut Farmer, a quirky drama about a retired NASA astronaut turned farmer (Billy Bob Thornton) who builds a spacecraft in his barn; and in the higher-profile supernatural thriller The Number 23, playing wife to an unraveling Jim Carrey.

Trivia: Began his broadcasting career in radio, working as a station news director. His talk show premiered in Dayton, OH, in 1967 and went national three years later. Most frequent guest was consumer advocate Ralph Nader, who appeared on the show 34 times between 1968 and '96. Met second wife Marlo Thomas when she was a guest on his show in 1977. Penned the autobiography Donahue: My Own Story in 1980 and the book The Human Animal in 1985. Appeared on The Oprah Winfrey Show in 2010 with fellow talkers Sally Jessy Raphael, Geraldo Rivera, Ricki Lake and Montel Williams. Has won 20 Daytime Emmys, including one for lifetime achievement.

Trivia: Anyone who watched the old TV sitcom Make Room for Daddy will remember that it was produced by a company called Marterto. This corporate name was an amalgam of the names of Danny Thomas' children: Margaret, Terry, and Tony. By 1959, Margaret Thomas had undergone a little cosmetic surgery, changed her name to Marlo Thomas, and launched an acting career on stage and TV. After guest starring in dozens of programs, she starred in her own series, That Girl, in which she played an aspiring actress with a benevolent despot of a father (where did that concept come from?). That Girl ran from 1966 through 1970, after which Thomas concentrated on Broadway appearances and occasional films like Thieves (1971). Extremely active in social and political causes during the next two decades, Thomas nonetheless found time to star in several made-for-TV movies and also co-produce the Emmy-winning children's TV special Free to Be...You and Me. She won additional Emmys for producing the 1988 follow-up Free to Be...a Family; for hosting the 1980 special The Body Human: Facts for Girls; and for her outstanding dramatic performance as an institutionalized mental patient in the TV film Nobody's Child (1986). Long a marital holdout, Marlo Thomas closed out the 1970s by walking down the aisle with talk-show host Phil Donahue. She continued to appear intermittently on the big and small screens over the next thirty years on a variety of projects including Consenting Adults, Reunion, Friends, Deuce Bigelow: Male Gigolo, Ally McBeal, In the Woods, and LOL.