Trivia: Actress Patricia Arquette is the granddaughter of Cliff Arquette, the daughter of character actor Lewis Arquette, and the sister of actors Rosanna Arquette, David Arquette and Alexis Arquette. Inaugurating her own film career in the mid-'80s, the actress came into her own with a gallery of fine portrayals in the '90s. In 1993 alone, she was seen as the hero's cousin/inamorata in Ethan Frome; the strung-out heroine in the stylishly violent road movie True Romance; and the hero's lesbian sister in Inside Monkey Zetterland. Arquette closed out 1994 on a fine note with her sympathetic portrayal of Kathy O'Hara, the second wife of Hollywood's "world's worst director," in Tim Burton's Ed Wood. The following year included a starring role in John Boorman's Beyond Rangoon and a marriage to actor Nicolas Cage. In 1996, Arquette had lead roles in a number of films, most notably David O. Russell's Flirting With Disaster, in which she played Ben Stiller's put-upon wife. She then switched gears with starring roles in David Lynch's Lost Highway and the thriller Nightwatch. She tried her hand at a Western in 1998, playing the object of Woody Harrelson's and Billy Crudup's desires in Stephen Frears' The Hi-Lo Country. Despite an interesting premise and excellent cast, the film flopped, but Arquette continued to work steadily the following year, with lead roles in the black comedy Goodbye Lover; Stigmata, in which she starred opposite Gabriel Byrne as the unwitting target of a supernatural phenomenon; and Martin Scorsese's Bringing out the Dead, a film starring Arquette's then-husband Cage as a burnt-out paramedic.Following the weightiness of the creepy Stigmata and the disturbing Bringing Out the Dead, Arquette took things in a decidedly lighter direction with her next two projects. In 2000, she played Adam Sandler's love-interest in the comedy Little Nicky, while the following year found her opposite Tim Robbins in the off-the-wall Human Nature. Written by Being John Malkovich scribe Charlie Kaufman, Human Nature was the feature debut from acclaimed music-video director Michel Gondry and featured Arquette as a woman cursed with a coat of fur covering her body.As the decade progressed, audiences could see Arquette in projects ranging from the star-studded documentary Searching for Debra Winger to the sleeper family film Holes. Then in 2005, Arquette found a truly resonant role, starring the psychic Allison Dubois on the extremely popular supernatural drama Medium. The show would run from 2005 to 2011, and Arquette would follow it up with a role alongside Bill Murray and Jason Schwartzman in A Glimpse Inside the Mind of Charles Swan III.In 2014, Arquette enjoyed the biggest critical success of her career playing the mother in Richard Linklater's universally praised Boyhood. Shot over the course of 12 years, the movie scored Arquette numerous year-end accolades, including an Oscar nomination for Best Supporting Actress.

Trivia: One of Hollywood's standbys for playing genial everymen during the 1980s, 1990s, and 2000s, Jake Weber was born in Britain on March 19th, 1964.. His roles typically constituted bit parts in A-list Hollywood features, beginning with that of Kyra Sedgwick's (unnamed) boyfriend in the Oliver Stone-directed period saga Born on the Fourth of July (1989) and continuing with work for directors including Sidney Lumet (A Stranger Among Us, 1992), the late Alan J. Pakula (The Pelican Brief, 1993) and Martin Brest (Meet Joe Black, 1998). Weber fortified his nice-guy image -- and scored one of his premier leads -- as Dr. Matt Crower, a kindly physician who takes charge of a young boy and protects him from a possessed sheriff -- in actor-turned-producer Shaun Cassidy's short-lived supernatural drama series American Gothic (1995) on CBS. Unfortunately, that program soon folded after it first bowed, as did the Mike Binder sitcom The Mind of the Married Man (2001), in which Weber signed on as one of the leads, Chicago newspaper employee Jake Berman. After a substantial role in the gory horror remake Dawn of the Dead (2004), Weber played one of the leads in the popular CBS series Medium -- as Joe Dubois, the husband of a woman (Patricia Arquette) plagued by psychic visions, who uses her ability to help solve crimes.

Trivia: First acting experiences were as a mime and a street performer. Directed inmates in theater productions at the New Mexico State Penitentiary. Worked with Samuel L. Jackson in numerous films, including Do the Right Thing, Jungle Fever, White Sands and Jurassic Park. Was a regular on the series Medium, and his daughter, Olivia, appeared in a few episodes as his character's daughter.

Trivia: A striking girl even at the tender age of seven, Sofia Vassilieva began her career in show business as a child model. Within a few years, she was appearing on an episode of the CBS series The Agency, and in the made-for-TV movie The Brady Bunch in the White House. Vassilieva then took on the role of beloved children's book heroine Eloise for two TV movies about the character. Then in 2005, the then 13 year old was cast as Ariel, the daughter of Patricia Arquette's character on the supernatural drama Medium. She would stick with the series for several seasons, but also took on other projects, like the role of a girl suffering from leukemia in the 2009 drama My Sister's Keeper.

Trivia: Appeared in the music video for Norah Jones' "Sunrise." Guest hosted The View in 2007, the youngest person to do so. Served as a special correspondent for Nickelodeon's Kids' Choice Awards in 2007.

Trivia: Born in England, he moved with his family to Vancouver when he was 6 months old. Appeared in several television commercials as a child. TV debut was on 21 Jump Street in 1987. First big break came when he was cast as one of the survivors in the film Alive with Ethan Hawke.

Trivia: Was named after a 19th-century ancestor, a physician and author. First role ever was as Hansel in a third-grade production of Hansel and Gretel. Acted on stage in New York City before beginning his MFA program at the University of California, San Diego. Directed a dramatic short film called Song in a Convenience Store in 2010. Known mostly for playing unstable and disturbing characters before landing the role of reformed lupine clockmaker Monroe on NBC's Grimm in 2011.