Trivia: For better or worse, leading actor Kelsey Grammer's name will probably forever be associated with the pompous, garrulous, and self-absorbed but lovable psychiatrist Frasier Crane, a character Grammer has played on television since he first appeared on the NBC sitcom Cheers, in 1984, as a love interest for Shelley Long. Though Frasier was not intended to become a series regular, Grammer's performance of the blowhard neurotic charmed audiences and he remained with Cheers through its 1993 demise. At the beginning of the 1993-1994 television season, Grammer's character was resurrected in his own show and moved from Boston to Seattle, where he became a radio psychologist and faced a whole slew of folks just waiting to poke metaphorical pins in his hot air balloon. Thanks to excellent performances and top-notch writing, Frasier became as big a hit as its predecessor. Grammer won three Emmy awards and was nominated for seven more (twice for Cheers, once for his guest appearance on a 1992 episode of Wings, four times for Frasier) for playing the character. Born on St. Thomas, one of the U.S. Virgin Islands, Grammer knew extreme tragedy in youth. Following the shooting death of his father when he was a boy, he was raised in New Jersey and then Florida, by his mother and grandfather. His grandfather died before Grammer became a teen. When he was 20, his sister was abducted and violently murdered. Five years later, he lost two half brothers in a diving accident. As a young man, Grammer found comfort in Shakespeare; with his acting debut in a high school production of The Little Foxes came an interest in pursuing drama as a career. He enrolled in Juilliard, but dropped out after two years to work at San Diego's Old Globe Theater, where he gained three years' invaluable experience performing in Shakespearean and classical dramas; afterward, Grammer performed in productions across the country. He eventually made it to Broadway, where he appeared in various productions, including Othello. Prior to playing Frasier, Grammer appeared occasionally on television and had regular roles in three soap operas, including One Life to Live. He continues to occasionally guest star on other series. Fans of the animated satire The Simpsons will recognize his periodic voice characterization as the venomous Sideshow Bob. Miniseries and telemovies in which he has appeared include London Suite and Beyond Suspicion. Grammer made his feature film debut with a small role in Top of the Hill (1989) and had his first starring role in the much-panned comedy Down Periscope (1996). In addition to his Emmy kudos, Grammer has received an American Comedy Award, two Golden Globes, and a People's Choice Award. In 1995, he published his autobiography So Far.Grammer would spend the following years taking on TV roles on shows like Back to You and Boss, but would find even more success as a producer, helping bring shows like The Game, Girlfriends, Hank, Medium, and World Cup Comedy to fruition. In 2014, he returned to acting in a big way, making a cameo appearance in X-Men: Days of Future Past, reprising his role as Beast, playing the bad guy in Transformers: Age of Extinction, and returning to television in the FX series Partners.

Trivia: Although he is best known for his role as anal-retentive psychiatrist extraordinaire Niles Crane on the celebrated sitcom Frasier, David Hyde Pierce has also done considerable work on the stage and screen. Fair, birdlike, and bearing an uncanny resemblance to Frasier co-star Kelsey Grammer, Pierce is one of the entertainment business' finest purveyors of a certain kind of blue-blooded neuroticism, and, in the eyes of some viewers, has even gone so far as to make insecurity perversely sexy.Born in Saratoga Springs, New York, on April 3, 1959, Pierce was raised in what he has described as a "very run-of-the-mill, middle-class" household. When he was eight, he began taking piano lessons, and he decided to pursue a career as a concert pianist. He continued to train until he got to Yale University, where he realized that he was better suited to the acting profession. Following graduation, Pierce moved to New York and did a brief stint as a tie salesman at Bloomingdale's before being cast in a Broadway play. Although the production was a flop, Pierce continued to work on the stage in New York and Chicago for several years and was eventually cast as a suicidal congressman on the short-lived sitcom The Powers That Be in 1992. His work on the show, coupled with his resemblance to Kelsey Grammer, led to his casting on Frasier the following year.Frasier proved to be the turning point in Pierce's career. His portrayal of Niles, aside from winning him a slew of awards, including an Emmy, also provided a number of opportunities for the actor on the big screen. Pierce, who had been acting sporadically in films since the early '80s, could be seen in supporting roles in such '90s films as Sleepless in Seattle (1993), Nixon (1995), in which he played John Dean, and the animated A Bug's Life (1998), for which he provided the voice of a stick insect.As the first decade of the 21st century opened, Pierce began appearing in more and more feature films, selecting an eclectic array of roles that utitlized his strengths without resorting to rehashing the Niles Crane character. Diverse in their genre and theme, the projects also ranged in their levels of success and acclaim. The 2000 comedy Isn't She Great was an abysmal failure, while the indie films Wet Hot American Summer and Full Frontal both left audiences and critics fiercely split. Pierce also continued to flex his voice skills in the animated features Osmosis Jones and Treasure Planet.One of Pierce's best-received roles came in 2003, when he costarred in the tongue-in-cheek comedy Down With Love. While not much of a box-office hit, the film managed to charm many critics with its wall-to-wall homages to 1960s sex-comedies. A year later, Pierce again showed up sans-body, providing the voice of Abe Sapien in the comic-book adaptation Hellboy. He reunited with Hellboy creator Mike Mignola's animated comic adaptation The Amazing Screw-On Head to voice the role of the dreaded Emperor Zombie in 2006, and joined the cast of The Perfect Host in 2010 for a leading role as Warwick Wilson, whose genteel façade hides a deep rage and mental instability.

Trivia: A distinctive-looking, grey-haired British character actor, John Mahoney worked onstage in his teens, and moved to the U.S. at 19. In his mid-30s, while employed as an editor in Chicago, he decided to renew his interest in acting, and he enrolled in classes at a local theater co-founded by playwright David Mamet; he landed a role in a Mamet play and left his job for the part. At the urging of actor John Malkovich, he went on to join Chicago's celebrated Steppenwolf Theater; eventually he appeared in more than 30 plays. For his work in the Broadway play House of Blue Leaves he won a Tony and a Clarence Derwent Award. For his work in the lead role of Orphans (on Broadway and in Chicago) he won a Theater World Award. He still lives in Chicago, and maintains his connection with Steppenwolf. Mahoney debuted onscreen in Mission HIll (1982), but his screen breakthrough came in his fifth film, Barry Levinson's popular comedy Tin Men (1987); afterwards he went on to better parts in more noteworthy movies, and has avoided typecasting in a busy screen career. Mahoney's TV credits include Favorite Son and House of Blue Leaves, in which he reprised his stage role; he has since achieved wide popularity as Martin Crane, Frasier Crane's crochety father, on the NBC sitcom Frasier.

Trivia: Began studying ballet at a very early age, but hurt her ankle when she was 18 and was forced to give it up. Appeared in David Lee Roth's video for "California Girls." Lived for a time with her best friend Faith Ford, whom she met in acting class. Cofounded the production company Bristol Cities with Frasier costar Peri Gilpin in 1998. Since her first pregnancy wasn't written into Frasier, her character, Daphne, was sent off to a fat camp and was said to have lost 9 pounds, 12 ounces---the weight of Jane's daughter when she was born. Made her Broadway debut in Cabaret as Sally Bowles in 2002. Reunited with Fraiser alum Wendy Malick to costar in the TV Land sitcom Hot in Cleveland.

Trivia: With a father who was a famous local radio and television celebrity, a model mother who appeared in television, and a working relationship with Wings producer Roz Doyle in her past, it may all seem like an obscure cosmic joke that pretty Peri Gilpin would rise to fame as radio producer Roz Doyle on the smash television sitcom Frasier, though the longtime actress would likely credit her success to hard work rather than astrological coincidence.Born in Waco, TX, and raised in Dallas, Gilpin began acting on stage with the Dallas Theater Company at the age of eight, a fact that helped her shake stage fright and gain the confidence that would accompany her through numerous future auditions. A Skyline High School graduate, Gilpin later studied acting at both the University of Texas at Austin and London's British-American Academy. Upon returning to the U.S., Gilpin worked as a makeup artist in the Dallas area before taking an apprenticeship with the Williamstown Theater Festival. A chance meeting with actress Blythe Danner resulted in Gilpin gaining some support within the industry, and it wasn't long before Gilpin's dreams were coming true with roles on television's Flesh 'n' Blood and 21 Jump Street. A role on Cheers followed shortly after, and when a spin-off series entitled Frasier became an unexpected hit, Gilpin found the role that would bring her into households across the country on a weekly basis. Appearing frequently on such made-for-television films as The Secret She Carried (1996) and Laughter on the 23rd Floor (2000) while simultaneously essaying her role on Frasier, Gilpin (who was named after the animated Disney character Peri the squirrel) has also loaned her voice to such animated projects as television's Hercules and the computer-animated feature Final Fantasy: The Spirits Within (2001). Throughout the 2000's and 2010's, Gilpin remained active, starring most notably on the dance series Make It or Break It.

Trivia: It was shortly after moving to Seattle from Illinois that the Washington, D.C. native realized her calling on the stage; a role in a junior high school production of Pinocchio eventually led her to become involved with the local community theater scene. Though Adams would initially enroll in Seattle's Cornish Institute as a political science major, the call of the stage proved too much to resist and she eventually packed her bags and opted to follow the bright beacon of the Broadway lights. Once she was in New York, Adams studied at Juilliard under the tutelage of Bill Kahn, later appearing in a Playwrights Horizons production of The Nice and the Nasty before landing her first Broadway role as the virginal Dierdre in Paul Rudnick's I Hate Hamlet. Moonlighting as a preschool teacher as a means to maintain her sanity during her downtime between roles, Adams set her sights on the screen after making her debut in the 1985 comedy Bombs Away! -- eventually realizing that if she was going to make it in film she would have to make the move to Los Angeles. In the early years of her Hollywood career, Adams got little chance to truly light up the screen since her roles were mainly of the supporting variety, but parts in such widely seen releases as Mrs. Parker and the Vicious Circle, Father of the Bride II, and Kansas City did help to build her resumé and increase her exposure. A Tony-winning role in the 1994 production of An Inspector Calls also served to gain Adams some respect on-stage, and in 1998, she finally got her big break onscreen thanks to her endearing performance as plain Jane, sad sack Joy Jordan in Happiness. Though it was obvious to all who saw the film that Adams certainly had the talent to carry a film, Hollywood still relegated her to supporting roles in Songcatcher, Wonder Boys, and Orange County. If fans had wondered where Adams disappeared to following her small but memorable performance in Orange County, their questions were answered when she appeared in a small capacity in director Michel Gondry's Eternal Sunshine of the Spotless Mind. Adams would remain active over the next several years, appearing most notably in movies like The Brave One, and on TV series like Hung.

Trivia: S. Epatha Merkerson is a Tony-nominated and Obie-winning, African-American stage actress, but is best known for her portrayal of detective squad chief Lt. Anita Van Buren in the series Law and Order. Born and raised in Detroit as the youngest of five children, she was a fine arts graduate of Wayne State University and began her New York theater career in the late 1970s. Merkerson was nominated for a Tony award for Best Actress for her performance as Berniece in The Piano Lesson and won an Obie award in 1992 for her work in I'm Not Stupid. Her screen credits include Jacob's Ladder and Loose Cannons and, perhaps most visibly, her role as Joe Morton's terrified wife in James Cameron's Terminator 2: Judgment Day. Merkerson made her television debut as Reba, the Mail Lady on Pee Wee's Playhouse, and has appeared on The Cosby Show, among other series, but her most important single television appearance may have been in the first season Law and Order show "Mushrooms," in which she portrayed the grief-stricken mother of an 11-month-old boy who is shot accidentally. Her work was not only memorable to the audience during that key first season, but also to the producers, who later picked Merkerson for the role of the new detective squad chief in the series' fourth season--a role she continued to play for over ten years. Merkerson's talent on the small screen led to roles in numerous TV movies such as Breaking Through and A Mother's Prayer, as well as roles in such films as Radio and The Rising Place. Still, her monumental gifts in both presence and interpretation may not have truly been utilized until she took the part of a strong matriarch who runs a 1960's boarding house in HBO's mini series Lackawanna Blues. Her first leading role in almost twenty years on screen, her performance earned her an Emmy Award as well as a Golden Globe. After her triumphant turn in Lackawanna Blues she returned to the big-screen in Craig Brewer's follow-up to Hustle & Flow, Black Snake Moan co-starring Christina Ricci and Samuel L. Jackson.Over the coming years, Merkerson would appear in a number of films, like The Six Wives of Henry Lefay and Mother and Child.

Trivia: Despite spending the first 25 years of his life in Adelaide, Australia, Anthony LaPaglia is best known for playing street-savvy Italian New Yorkers. This was not, however, LaPaglia's original plan. Rather than testing the waters of show business, LaPaglia traveled to the United States intending to pursue a full-time teaching career. As luck would have it, however, one of LaPaglia's odd jobs was a small role in Cold Steel (1987), a low-budget detective drama. LaPaglia began pursuing theater and television in his spare time -- one of his more notable early performances was in 1988's Frank Nitti: The Enforcer -- and considered himself a full-time actor by 1989, when he made his feature-film debut in Slaves of New York. It was 1990, however, when the young actor earned critical recognition for his role as an exceedingly polite mobster in Betsy's Wedding.LaPaglia continued to build his résuméthroughout the early '90s, most of which he spent playing either kindly policemen or good-hearted mobsters, and was delighted to work alongside a variety of noted actors so early in his career. Among those actors were Alan Alda in Betsy's Wedding, Michael Keaton in One Good Cop (1991), and Nathan Lane, Sharon Stone, and Kevin Bacon in He Said, She Said (1992). Later in 1992, LaPaglia could be found playing his first leading role in George Gallo's gangster farce 29th Street. Though the film did not fare particularly well, audiences were nonetheless impressed with LaPaglia's intensity, and he played a more serious gangster with great success opposite Susan Sarandon in The Client (1994). The actor switched gears for his next handful of films; in Mixed Nuts (1994) he played a disillusioned Santa Claus, while Empire Records (1995) found him as a down-on-his-luck store manager, and the Australian-helmed Brilliant Lies (1996) featured him as the defendant in a sketchy sexual-harassment case.Despite a smattering of mediocre films between 1995 and the early 2000s, LaPaglia continued to earn critical acclaim for many of his endeavors, such as Steve Buscemi's directorial debut, Trees Lounge (1996), for which LaPaglia joined a star-studded supporting cast, as well as for his role as a detective in Spike Lee's Summer of Sam (1999). Luckily for him, 2000 and 2001 proved excellent for his career, as it was during this period that he played a wealthy businessman in The House of Mirth and an adulterous police detective in Lantana. In addition to receiving international success, Lantana earned LaPaglia the prestigious Best Actor award from the Australian Film Institute, as well as a nomination from the Film Critics Circle. In the meantime, he was adding several major television credits to his résumé, including a starring role as the head of the FBI's Missing Persons Squad on CBS's Without a Trace, and a recurring role on the long-running sitcom Frasier, a performance for which he would receive an Emmy in 2002. Far removed from his fledgling days as a teacher, 2002 also found LaPaglia working with Val Kilmer for The Salton Sea; Sigourney Weaver for The Guys; Robert De Niro and Billy Crystal in Analyze That; and Eric Stoltz in Happy Hour. In 2003, after filming Manhood with Janeane Garofalo and the late John Ritter, LaPaglia agreed to star in director Josh Sternfeld's Winter Solstice (2004).Over the next several years, LaPaglia would appear in a number of big screen projects, like Balibo (2009), Overnight (2012) and A Good Marriage (2014).

Trivia: Born in a German refugee camp, actor Saul Rubinek was raised in Canada, where he began his career. After several years of activity with the Toronto Free Theater, the versatile Rubinek headed for New York, where he worked in repertory and on Broadway. Rubinek's performance as the best friend of religious cult member Nick Mancuso in the little-seen Ticket to Heaven (1981) was a critical coup for the actor. A reliable presence in such meaty supporting roles as the Ned Buntline-ish dime novelist in The Unforgiven (1994), and Hollywood producer Lee Donowitz in True Romance, Rubinek would spend the coming decades working steadily in films like I Love Trouble and Nixon, as well as on TV shows like A Nero Wolfe Mystery, Frasier, Blind Justice, and Warehouse 13.