Trivia: For better or worse, leading actor Kelsey Grammer's name will probably forever be associated with the pompous, garrulous, and self-absorbed but lovable psychiatrist Frasier Crane, a character Grammer has played on television since he first appeared on the NBC sitcom Cheers, in 1984, as a love interest for Shelley Long. Though Frasier was not intended to become a series regular, Grammer's performance of the blowhard neurotic charmed audiences and he remained with Cheers through its 1993 demise. At the beginning of the 1993-1994 television season, Grammer's character was resurrected in his own show and moved from Boston to Seattle, where he became a radio psychologist and faced a whole slew of folks just waiting to poke metaphorical pins in his hot air balloon. Thanks to excellent performances and top-notch writing, Frasier became as big a hit as its predecessor. Grammer won three Emmy awards and was nominated for seven more (twice for Cheers, once for his guest appearance on a 1992 episode of Wings, four times for Frasier) for playing the character. Born on St. Thomas, one of the U.S. Virgin Islands, Grammer knew extreme tragedy in youth. Following the shooting death of his father when he was a boy, he was raised in New Jersey and then Florida, by his mother and grandfather. His grandfather died before Grammer became a teen. When he was 20, his sister was abducted and violently murdered. Five years later, he lost two half brothers in a diving accident. As a young man, Grammer found comfort in Shakespeare; with his acting debut in a high school production of The Little Foxes came an interest in pursuing drama as a career. He enrolled in Juilliard, but dropped out after two years to work at San Diego's Old Globe Theater, where he gained three years' invaluable experience performing in Shakespearean and classical dramas; afterward, Grammer performed in productions across the country. He eventually made it to Broadway, where he appeared in various productions, including Othello. Prior to playing Frasier, Grammer appeared occasionally on television and had regular roles in three soap operas, including One Life to Live. He continues to occasionally guest star on other series. Fans of the animated satire The Simpsons will recognize his periodic voice characterization as the venomous Sideshow Bob. Miniseries and telemovies in which he has appeared include London Suite and Beyond Suspicion. Grammer made his feature film debut with a small role in Top of the Hill (1989) and had his first starring role in the much-panned comedy Down Periscope (1996). In addition to his Emmy kudos, Grammer has received an American Comedy Award, two Golden Globes, and a People's Choice Award. In 1995, he published his autobiography So Far.Grammer would spend the following years taking on TV roles on shows like Back to You and Boss, but would find even more success as a producer, helping bring shows like The Game, Girlfriends, Hank, Medium, and World Cup Comedy to fruition. In 2014, he returned to acting in a big way, making a cameo appearance in X-Men: Days of Future Past, reprising his role as Beast, playing the bad guy in Transformers: Age of Extinction, and returning to television in the FX series Partners.

Trivia: Although he is best known for his role as anal-retentive psychiatrist extraordinaire Niles Crane on the celebrated sitcom Frasier, David Hyde Pierce has also done considerable work on the stage and screen. Fair, birdlike, and bearing an uncanny resemblance to Frasier co-star Kelsey Grammer, Pierce is one of the entertainment business' finest purveyors of a certain kind of blue-blooded neuroticism, and, in the eyes of some viewers, has even gone so far as to make insecurity perversely sexy.Born in Saratoga Springs, New York, on April 3, 1959, Pierce was raised in what he has described as a "very run-of-the-mill, middle-class" household. When he was eight, he began taking piano lessons, and he decided to pursue a career as a concert pianist. He continued to train until he got to Yale University, where he realized that he was better suited to the acting profession. Following graduation, Pierce moved to New York and did a brief stint as a tie salesman at Bloomingdale's before being cast in a Broadway play. Although the production was a flop, Pierce continued to work on the stage in New York and Chicago for several years and was eventually cast as a suicidal congressman on the short-lived sitcom The Powers That Be in 1992. His work on the show, coupled with his resemblance to Kelsey Grammer, led to his casting on Frasier the following year.Frasier proved to be the turning point in Pierce's career. His portrayal of Niles, aside from winning him a slew of awards, including an Emmy, also provided a number of opportunities for the actor on the big screen. Pierce, who had been acting sporadically in films since the early '80s, could be seen in supporting roles in such '90s films as Sleepless in Seattle (1993), Nixon (1995), in which he played John Dean, and the animated A Bug's Life (1998), for which he provided the voice of a stick insect.As the first decade of the 21st century opened, Pierce began appearing in more and more feature films, selecting an eclectic array of roles that utitlized his strengths without resorting to rehashing the Niles Crane character. Diverse in their genre and theme, the projects also ranged in their levels of success and acclaim. The 2000 comedy Isn't She Great was an abysmal failure, while the indie films Wet Hot American Summer and Full Frontal both left audiences and critics fiercely split. Pierce also continued to flex his voice skills in the animated features Osmosis Jones and Treasure Planet.One of Pierce's best-received roles came in 2003, when he costarred in the tongue-in-cheek comedy Down With Love. While not much of a box-office hit, the film managed to charm many critics with its wall-to-wall homages to 1960s sex-comedies. A year later, Pierce again showed up sans-body, providing the voice of Abe Sapien in the comic-book adaptation Hellboy. He reunited with Hellboy creator Mike Mignola's animated comic adaptation The Amazing Screw-On Head to voice the role of the dreaded Emperor Zombie in 2006, and joined the cast of The Perfect Host in 2010 for a leading role as Warwick Wilson, whose genteel façade hides a deep rage and mental instability.

Trivia: A distinctive-looking, grey-haired British character actor, John Mahoney worked onstage in his teens, and moved to the U.S. at 19. In his mid-30s, while employed as an editor in Chicago, he decided to renew his interest in acting, and he enrolled in classes at a local theater co-founded by playwright David Mamet; he landed a role in a Mamet play and left his job for the part. At the urging of actor John Malkovich, he went on to join Chicago's celebrated Steppenwolf Theater; eventually he appeared in more than 30 plays. For his work in the Broadway play House of Blue Leaves he won a Tony and a Clarence Derwent Award. For his work in the lead role of Orphans (on Broadway and in Chicago) he won a Theater World Award. He still lives in Chicago, and maintains his connection with Steppenwolf. Mahoney debuted onscreen in Mission HIll (1982), but his screen breakthrough came in his fifth film, Barry Levinson's popular comedy Tin Men (1987); afterwards he went on to better parts in more noteworthy movies, and has avoided typecasting in a busy screen career. Mahoney's TV credits include Favorite Son and House of Blue Leaves, in which he reprised his stage role; he has since achieved wide popularity as Martin Crane, Frasier Crane's crochety father, on the NBC sitcom Frasier.

Trivia: Began studying ballet at a very early age, but hurt her ankle when she was 18 and was forced to give it up. Appeared in David Lee Roth's video for "California Girls." Lived for a time with her best friend Faith Ford, whom she met in acting class. Cofounded the production company Bristol Cities with Frasier costar Peri Gilpin in 1998. Since her first pregnancy wasn't written into Frasier, her character, Daphne, was sent off to a fat camp and was said to have lost 9 pounds, 12 ounces---the weight of Jane's daughter when she was born. Made her Broadway debut in Cabaret as Sally Bowles in 2002. Reunited with Fraiser alum Wendy Malick to costar in the TV Land sitcom Hot in Cleveland.

Trivia: With a father who was a famous local radio and television celebrity, a model mother who appeared in television, and a working relationship with Wings producer Roz Doyle in her past, it may all seem like an obscure cosmic joke that pretty Peri Gilpin would rise to fame as radio producer Roz Doyle on the smash television sitcom Frasier, though the longtime actress would likely credit her success to hard work rather than astrological coincidence.Born in Waco, TX, and raised in Dallas, Gilpin began acting on stage with the Dallas Theater Company at the age of eight, a fact that helped her shake stage fright and gain the confidence that would accompany her through numerous future auditions. A Skyline High School graduate, Gilpin later studied acting at both the University of Texas at Austin and London's British-American Academy. Upon returning to the U.S., Gilpin worked as a makeup artist in the Dallas area before taking an apprenticeship with the Williamstown Theater Festival. A chance meeting with actress Blythe Danner resulted in Gilpin gaining some support within the industry, and it wasn't long before Gilpin's dreams were coming true with roles on television's Flesh 'n' Blood and 21 Jump Street. A role on Cheers followed shortly after, and when a spin-off series entitled Frasier became an unexpected hit, Gilpin found the role that would bring her into households across the country on a weekly basis. Appearing frequently on such made-for-television films as The Secret She Carried (1996) and Laughter on the 23rd Floor (2000) while simultaneously essaying her role on Frasier, Gilpin (who was named after the animated Disney character Peri the squirrel) has also loaned her voice to such animated projects as television's Hercules and the computer-animated feature Final Fantasy: The Spirits Within (2001). Throughout the 2000's and 2010's, Gilpin remained active, starring most notably on the dance series Make It or Break It.

Trivia: One of Britain's most distinguished stage performers, Derek Jacobi is one of two actors (the other being Laurence Olivier) to hold both Danish and English knighthoods. Primarily known for his work on the stage, he has also made a number of films and remains best-known to television audiences for his stunning portrayal of the titular Roman emperor in I, Claudius.Born in Leytonstone, East London, on October 22, 1938, Jacobi was raised with a love of film, and he began performing on the stage while attending an all-boys school. Thanks to the school's single sex population, his first roles with the drama club -- until his voice broke -- were all female. It was with one of his first male roles that Jacobi earned his first measure of acclaim: playing Hamlet in a school production staged at the 1957 Edinburgh Festival, he made enough of an impression that he was approached by an agent from Twentieth Century Fox. Ultimately deemed too young to be signed to the studio, Jacobi instead went to Cambridge University, where he studied history and continued acting. His stage work at Cambridge was prolific and allowed him to work with classmates Ian McKellen and Trevor Nunn, and, thanks to his performance as Edward II, landed him his first job after graduation. Jacobi acted with the Birmingham Repertory Theatre until his portrayal of Henry VIII attracted the attention of Laurence Olivier. Olivier was so impressed with Jacobi's work that he invited him to London to become one of the eight founding members of the prestigious National Theatre.Jacobi went on to become one of his country's most steadily employed and respected actors, performing in numerous plays over the years on both sides of the Atlantic (in 1985, he won a Tony Award for his work in Much Ado About Nothing). He also branched out into film and television, making his film debut with a secondary role in Douglas Sirk's Interlude (1957). He acted in numerous film adaptations of classic plays, including Othello (1965) and The Three Sisters (1970). However, it was through his collaborations with Kenneth Branagh on various screen adaptations of Shakespeare that he became most visible to an international film audience, appearing as the Chorus in Branagh's acclaimed 1989 Henry V and as Claudius in the director's 1996 full-length adaptation of Hamlet. Jacobi made one of his most memorable (to say nothing of terrifying) screen impressions in Branagh's Hitchcock-inspired Dead Again (1991), portraying a hypnotist with a very shady background. In 1998, Jacobi earned more recognition with his portrayal of famed painter Francis Bacon in John Maybury's controversial Love Is the Devil: Study for a Portrait of Francis Bacon.On television, in addition to his celebrated work in I, Claudius, Jacobi has also earned praise for his roles in a number of other productions. In 1989, he won an Emmy for his performance in the 1988 adaptation of Graham Greene's The Tenth Man.In 1994 he began a successful run as a mystery-solving monk in the TV series Cadfael, a program that ran for three years. He had a Shakespeare heavy 1996 playing Claudius opposite Branagh's Hamlet, and appearing in Al Pacino's documentary Looking for Richard. He lent his voice to the animated version of Beowulf. He began the new century appearing in the Best Picture winner Gladiator, and was part of the rich ensemble compiled by Robert Altman for Gosford Park. In 2005 he was in the cast of the hit children's film Nanny McPhee, and two years later he was in The Golden Compass. In 2010 he appeared in another Oscar winning best picture when he was in The King's Speech. The next year he appeared in Anonymous as well as My Week With Marilyn.

Trivia: British actor Patrick Macnee barely had time to earn his Eton school tie when he began training for his career on a scholarship to the Webber Douglas School of Dramatic Art. While serving with the Royal Navy during World War II, Macnee made his first film appearance with a small role in The Life and Death of Colonel Blimp (1943). He continued essaying such featured roles as Young Marley in the 1951 Christmas Carol before coming to Broadway with the Old Vic troupe in 1954. He decided to stay in Hollywood a while, appearing in several TV shows and such films as Les Girls (1957). He would later describe most of his roles during this period as "villainy in a tri-corner hat." In 1960, Macnee traded his period duds for a bowler and three-piece suit when he began his long run as sophisticated secret agent John Steed on the British TV series The Avengers (incidentally, the murder that Macnee was "avenging" in the early episodes was that of a woman played by his then-wife Kate Woodville). He remained the one permanent fixture on The Avengers until its demise in 1968, appearing opposite three different jumpsuit-clad leading ladies: Honor Blackman, Diana Rigg and Linda Thorson. Macnee also showed up as a supervisor of sort in the 1977 "retro" series The New Avengers, leaving the karate and gunplay to Joanna Lumley and Gareth Hunt. In America, Patrick Macnee appeared regularly on the TV series Gavilan (1982), Empire (1984), and Lightning Force (1991). Macnee continued working through the 2000s, including a voice appearance in the 1998 Avengers movie. Patrick Macnee passed away in 2015, at age 93.