San Francisco 49ers (5-2) at Houston Texans (2-4). From NRG Stadium. QB Mac Jones and the league-leading Niners passing game (271 ypg) face the feisty Houston defense (league-low 14.7 ppg allowed, eight takeaways last three games) head coached by ex-San Francisco DC DeMeco Ryans. RB Christian McCaffrey has been a force for San Francisco, whose defense faces QB C.J. Stroud eyeing their first INT.