San Francisco 49ers (6-4) at Arizona Cardinals (3-6). From State Farm Stadium. Jonathan Gannon's Cardinals try to end a 1-6 stretch of futility that began with a 16-15 loss to San Francisco on Eddy Pineiro's walk-off 35-yard field goal. For the Niners, QB Brock Purdy is in line to start for the first time since Week 4, facing an Arizona defense that mustered six takeaways the last two weeks.