Trivia: Born on a Belgian army base, curly brown-haired Johnny Galecki grew up in Chicago and started acting professionally at the age of 12. He made his feature film debut in 1988 as River Phoenix's little brother in A Night in the Life of Jimmy Reardon. He then assumed the role of Rusty Griswold in National Lampoon's Christmas Vacation, and gained his first regular role on a TV series as Robert Ulrich's son in American Dreamer. In 1991, he starred in the made-for-TV movie Backfield in Motion, co-starring the production team of Roseanne and Tom Arnold. The next year, Galecki joined the cast of Roseanne as Darlene's sensitive and put-upon boyfriend David Healy. He stayed on the show until its final season in 1997, although he wasn't on very much during its last few years. His other television credits include several guest appearances, leading roles in made-for-TV movies, and a part on the short-lived Head of the Class spin-off Billy. After Roseanne ended, he got back into features with small parts in I Know What You Did Last Summer, Bean, and Suicide Kings. He continued playing slightly effeminate sensitive males in The Opposite of Sex and Morgan's Ferry. After bit parts in Bounce, Playing Mona Lisa, and Vanilla Sky, Galecki played a leading role in the comedy thriller Bookies, which premiered at the 2003 Sundance Film Festival. In 2007 he landed the leading role in the sitcom The Big Bang Theory and it grew to be one of the most popular shows on TV, earning Galecki Emmy, Golden Globe, and Sag nominations in 2011 for his work on the show. He maintained his movie career in projects such as Hancock and In Time.

Trivia: First noticed by many viewers as Tim -- the Klingon-spouting "knight in training" involved with the mother of Mark (Peter Sarsgaard) in Zach Braff's gently observed comedy drama Garden State (2004) -- American actor Jim Parsons moved from this memorable debut into a sequence of periodic roles in U.S. features. These included Chris Terrio's urban ensemble drama Heights (2004), opposite Glenn Close and Elizabeth Banks, and Brad Silberling's comedy drama 10 Items or Less (2006), opposite Morgan Freeman and Paz Vega. His breakout success came when he was cast as uber-nerd Sheldon on The Big Bang Theory. His work on that show led to him scoring an Emmy win for Outstanding Lead Actor in a Comedy Series, and helped him earn small parts on the big screen in The Big Year and The Muppets.

Trivia: Though initially typecast in comedic roles -- including a small turn in Old School (2003), a contribution to Tracey Ullman in The Trailer Tales (2003), and work on MADtv -- American character actor Simon Helberg quickly branched out into diverse genres. He appeared as a CBS page in George Clooney's revered Edward R. Murrow biopic Good Night, and Good Luck., as a junior agent in Christopher Guest's For Your Consideration (2006), and in a recurring role on the Aaron Sorkin comedy drama Studio 60 on the Sunset Strip. In 2007, Helberg was cast in the regular role of Howard Wolowitz on the sitcom The Big Bang Theory, about a couple of nerdy physicists (Johnny Galecki and Jim Parsons) who struggle with women, and everything else outside the lab. In 2007, Helberg also made appearances in the comedies Mama's Boy and Walk Hard: The Dewey Cox Story. He played a young rabbi in the Coen brothers film A Serious Man (2009), and continued to make guest appearances on TV shows such as Kick Buttowski: Suburban Daredevil and Drunk History, while maintaining his regular status on The Big Bang Theory.

Trivia: Actor Kunal Nayyar first made a splash in Hollywood playing physicist Koothrappali on the series The Big Bang Theory, which debuted on CBS in 2007. In 2012 Nayyar voiced the character of Gupta in Ice Age: Continental Drift, and the following year he could be seen opposite Gina Gershon and Billy Campbell in the thriller, The Scribbler. In addition to his feature work Nayyar also co-wrote the critically acclaimed play Cotton Candy, which runs in New Delhi.

Trivia: Began her career as a comedian and had a one-woman show, The Miss Education of Jenna Bush, in which she played the daughter of former president George W. Bush. Co-wrote, directed and starred in the comedic short The Condom Killer. Toured with the political-satire group Gross National Product. Performs with The Realest Real Housewives show, in which comedians read transcripts from the Real Housewives franchise. Was a recurring guest star on series 3 of The Big Bang Theory before joining the cast as a series regular in series 4.

Trivia: Name means "water" in Hebrew. Had her big break in the 1988 film Beaches, playing the younger version of Bette Midler. Appeared in the music video for Michael Jackson's "Liberian Girl." Made her television debut in the 1980s fantasy series Beauty and the Beast. Best known for her role as the title character in the sitcom Blossom. Was successful in many voiceover roles in animated series, including Kim Possible and Hey Arnold! Appeared on a 2009 episode of What Not To Wear. Her The Big Bang Theory character, Amy Farrah Fowler, is a neurobiologist, corresponding to Bialik's real-life degrees in neuroscience. Is a spokesperson for the Holistic Moms Network and gave birth to her second son at home.

Trivia: Kaley Cuoco began modeling and acting at the tender age of six, when she was cast in the TV movie Quicksand: No Escape. Growing up in front of the camera, the young actress continued to appear as the requisite little girl in movies like Virtuosity and Picture Perfect until she was cast as teenage daughter Bridget on the sitcom 8 Simple Rules. TV would prove to be the actor's bread and butter, and she would go on to star on Charmed, 6Teen, and Monster Allergy, not to mention The Big Bang Theory, a show that earned her legions of fans as Penny, the hot neighbor of two geeky physicists (Johnny Galecki, Jim Parsons). Cuoco also continued to appear in films, though on a much smaller scale compared to her TV work. She appeared in a supporting role in the Easter film Hop in 2011, and played the female lead opposite Kevin Hart and Josh Gad in The Wedding Ringer in 2015.

Trivia: Studied acting with Uta Hagen. Had a recurring role on The Big Bang Theory starting with its second series, and was promoted to series regular in 2012 for the sixth series. Plays the owner of a comic-book shop in The Big Bang Theory, and once worked at a similar establishment in New York City. Both of his parents are schoolteachers. Has appeared in more than 30 US adverts, including Eggos and FedEx.

Trivia: Of the many performers to leap into films from the springboard of the television sketch comedy series Saturday Night Live, Bill Murray has been among the most successful and unpredictable, forging an idiosyncratic career allowing him to stretch from low-brow slapstick farce to intelligent adult drama. Born in Wilmette, IL, on September 21, 1950, Murray was an incorrigible child, kicked out of both the Boy Scouts and Little League. At the age of 20, he was also arrested for attempting to smuggle close to nine pounds of marijuana through nearby O'Hare Airport. In an attempt to find direction in his life, he joined his older brother, Brian Doyle-Murray, in the cast of Chicago's Second City improvisational comedy troupe. He later relocated to New York City, joining radio's National Lampoon Hour. Both Murray siblings were also in a 1975 off-Broadway spin-off, also dubbed The National Lampoon Hour; there Murray was spotted by sportscaster Howard Cosell, who recruited him for the cast of his ABC variety program, titled Saturday Night Live With Howard Cosell. On the NBC network, a program also named Saturday Night Live was creating a much bigger sensation; when, after one season, the show's breakout star Chevy Chase exited to pursue a film career, producer Lorne Michaels tapped Murray as his replacement. Murray too became a celebrity, developing a fabulously insincere and sleazy comic persona which was put to good use in his first major film, the 1979 hit Meatballs. He next starred as the famed gonzo journalist Hunter S. Thompson in the film biography Where the Buffalo Roam, a major disaster. However, 1980's Caddyshack was a masterpiece of slob comedy, with Murray memorable as a maniacal rangeboy hunting the gopher that is slowly destroying his golf course. The film launched him to the ranks of major stardom; the follow-up, the armed services farce Stripes, was an even bigger blockbuster, earning over 40 million dollars at the box office. Murray next appeared, unbilled, in 1982's Tootsie before starring with Dan Aykroyd and Harold Ramis in 1984's Ghostbusters. The supernatural comedy was one of the decade's biggest hits, earning over 130 million dollars and spawning a cartoon series, action figures, and even a chart-topping theme song (performed by Ray Parker Jr.). Murray now ranked among the world's most popular actors, and he next fulfilled a long-standing dream by starring in and co-writing an adaptation of the W. Somerset Maugham novel The Razor's Edge. Few fans knew what to make of his abrupt turn from broad farce to literary drama, however, and as a result the film flopped. Murray spent the next several years in self-imposed exile, making only a cameo appearance in the 1986 musical comedy Little Shop of Horrors. After much deliberation, he finally selected his comeback vehicle -- 1988's Scrooged, a black comic retelling of Dickens' A Christmas Carol. While it performed moderately well, it was not the smash many predicted. Nor was 1989's Ghostbusters II, which grossed less than half of the first picture. The 1990 crime comedy Quick Change, which Murray co-directed with Howard Franklin, was also a disappointment, but 1991's What About Bob? was an unqualified hit. In 1993, Murray earned his strongest notices to date for Groundhog Day, a sublime comedy directed by longtime conspirator Ramis. Beginning with 1994's acclaimed Ed Wood, in which he appeared as a transsexual, Murray's career choices grew increasingly eccentric; in 1996 alone, he starred in the little-seen Larger Than Life as a motivational speaker, co-starred as a bowling champion in Kingpin, and appeared as himself in the family film Space Jam. In 1998, Murray took on a similarly eccentric role in Wes Anderson's Rushmore. Playing a business tycoon competing with an equally eccentric 15-year-old (Jason Schwartzman) for the affections of a first grade teacher (Olivia Williams), Murray did some of his best work in years and won the Best Supporting Actor award from the New York Film Critics Circle. The film's success helped to put the actor back in the forefront, and he drew further exposure that year from his appearance as a sleazy lawyer in the relentlessly trashy Wild Things. The following year, he could be seen in Cradle Will Rock, Tim Robbins' look at the often contentious relationship between art and politics in 1930s America.Though the mere thought of Murray as Polonius in a film adaptation of William Shakespeare's Hamlet may have elicited dumbounded looks and confused laughter early in his career, that was precisely how the versatile thespian ushered in the new millennium in director Micheal Almereyda's modern updating of the classic drama. Subsequently landing laughs as the superspy point person Bosley in the big screen adaptation of the classic 1970's television hit Charlie's Angels, Murray's interpretation of the character would be taken over by popular comic Bernie Mac in the film's 2003 sequel. After taking a brief voyage into gross-out territory with the Farrelly brother's Osmosis Jones in 2001, a re-teaming with Rushmore director Anderson resulted in a small but memorable supporting performance in the same year's The Royal Tenenbaums. In 2003 Murray essayed the role that would offer what was perhaps his most heartfelt combination of personal drama and touching comedy to date in director Sofia Coppola's acclaimed indie film Lost in Translation. Cast as a washed up American actor who strikes up a tentative friendship with the young wife of a superstar photographer while on a stay in Japan to endorse a popular brand of whiskey, Murray's low-key charm proved the perfect balance to co-star Scarlett Johansson's youthful malaise. Virtually across the board, critics were bowled over by the subtle depth of Murray's performance, leading to Best Actor honors from The New York Film Critics Circle, The Boston Society of Film Critics, The Los Angeles Film Critics Association, The San Francisco Film Critics Circle, The National Society of Film Critics, The Golden Globes, and The Independent Spirit Awards. But the one award that remained elusive to Murray was Oscar. Though nominated, the prize ultimately went to Sean Penn for Mystic River.In 2004, along with providing the voice for a CGI version of Garfield the cat, Murray once again teamed up with director Wes Anderson, starring as as a world-renowned oceanographer in The Life Aquatic with Steve Zissou. While The Life Aquatic was met with mixed reviews, Murray's performance in the 2005 Jim Jarmusch film Broken Flowers netted virtually unanimous acclaim. Over the next several years, Murray would maintain his selective film career, appearing in acclaimed films like Get Low, Passion Play, and Moonrise Kingdom.