Trivia: Kaley Cuoco began modeling and acting at the tender age of six, when she was cast in the TV movie Quicksand: No Escape. Growing up in front of the camera, the young actress continued to appear as the requisite little girl in movies like Virtuosity and Picture Perfect until she was cast as teenage daughter Bridget on the sitcom 8 Simple Rules. TV would prove to be the actor's bread and butter, and she would go on to star on Charmed, 6Teen, and Monster Allergy, not to mention The Big Bang Theory, a show that earned her legions of fans as Penny, the hot neighbor of two geeky physicists (Johnny Galecki, Jim Parsons). Cuoco also continued to appear in films, though on a much smaller scale compared to her TV work. She appeared in a supporting role in the Easter film Hop in 2011, and played the female lead opposite Kevin Hart and Josh Gad in The Wedding Ringer in 2015.

Trivia: Born on a Belgian army base, curly brown-haired Johnny Galecki grew up in Chicago and started acting professionally at the age of 12. He made his feature film debut in 1988 as River Phoenix's little brother in A Night in the Life of Jimmy Reardon. He then assumed the role of Rusty Griswold in National Lampoon's Christmas Vacation, and gained his first regular role on a TV series as Robert Ulrich's son in American Dreamer. In 1991, he starred in the made-for-TV movie Backfield in Motion, co-starring the production team of Roseanne and Tom Arnold. The next year, Galecki joined the cast of Roseanne as Darlene's sensitive and put-upon boyfriend David Healy. He stayed on the show until its final season in 1997, although he wasn't on very much during its last few years. His other television credits include several guest appearances, leading roles in made-for-TV movies, and a part on the short-lived Head of the Class spin-off Billy. After Roseanne ended, he got back into features with small parts in I Know What You Did Last Summer, Bean, and Suicide Kings. He continued playing slightly effeminate sensitive males in The Opposite of Sex and Morgan's Ferry. After bit parts in Bounce, Playing Mona Lisa, and Vanilla Sky, Galecki played a leading role in the comedy thriller Bookies, which premiered at the 2003 Sundance Film Festival. In 2007 he landed the leading role in the sitcom The Big Bang Theory and it grew to be one of the most popular shows on TV, earning Galecki Emmy, Golden Globe, and Sag nominations in 2011 for his work on the show. He maintained his movie career in projects such as Hancock and In Time.

Trivia: First noticed by many viewers as Tim -- the Klingon-spouting "knight in training" involved with the mother of Mark (Peter Sarsgaard) in Zach Braff's gently observed comedy drama Garden State (2004) -- American actor Jim Parsons moved from this memorable debut into a sequence of periodic roles in U.S. features. These included Chris Terrio's urban ensemble drama Heights (2004), opposite Glenn Close and Elizabeth Banks, and Brad Silberling's comedy drama 10 Items or Less (2006), opposite Morgan Freeman and Paz Vega. His breakout success came when he was cast as uber-nerd Sheldon on The Big Bang Theory. His work on that show led to him scoring an Emmy win for Outstanding Lead Actor in a Comedy Series, and helped him earn small parts on the big screen in The Big Year and The Muppets.

Trivia: Though initially typecast in comedic roles -- including a small turn in Old School (2003), a contribution to Tracey Ullman in The Trailer Tales (2003), and work on MADtv -- American character actor Simon Helberg quickly branched out into diverse genres. He appeared as a CBS page in George Clooney's revered Edward R. Murrow biopic Good Night, and Good Luck., as a junior agent in Christopher Guest's For Your Consideration (2006), and in a recurring role on the Aaron Sorkin comedy drama Studio 60 on the Sunset Strip. In 2007, Helberg was cast in the regular role of Howard Wolowitz on the sitcom The Big Bang Theory, about a couple of nerdy physicists (Johnny Galecki and Jim Parsons) who struggle with women, and everything else outside the lab. In 2007, Helberg also made appearances in the comedies Mama's Boy and Walk Hard: The Dewey Cox Story. He played a young rabbi in the Coen brothers film A Serious Man (2009), and continued to make guest appearances on TV shows such as Kick Buttowski: Suburban Daredevil and Drunk History, while maintaining his regular status on The Big Bang Theory.

Trivia: Actor Kunal Nayyar first made a splash in Hollywood playing physicist Koothrappali on the series The Big Bang Theory, which debuted on CBS in 2007. In 2012 Nayyar voiced the character of Gupta in Ice Age: Continental Drift, and the following year he could be seen opposite Gina Gershon and Billy Campbell in the thriller, The Scribbler. In addition to his feature work Nayyar also co-wrote the critically acclaimed play Cotton Candy, which runs in New Delhi.

Trivia: Began her career as a comedian and had a one-woman show, The Miss Education of Jenna Bush, in which she played the daughter of former president George W. Bush. Co-wrote, directed and starred in the comedic short The Condom Killer. Toured with the political-satire group Gross National Product. Performs with The Realest Real Housewives show, in which comedians read transcripts from the Real Housewives franchise. Was a recurring guest star on series 3 of The Big Bang Theory before joining the cast as a series regular in series 4.

Trivia: Name means "water" in Hebrew. Had her big break in the 1988 film Beaches, playing the younger version of Bette Midler. Appeared in the music video for Michael Jackson's "Liberian Girl." Made her television debut in the 1980s fantasy series Beauty and the Beast. Best known for her role as the title character in the sitcom Blossom. Was successful in many voiceover roles in animated series, including Kim Possible and Hey Arnold! Appeared on a 2009 episode of What Not To Wear. Her The Big Bang Theory character, Amy Farrah Fowler, is a neurobiologist, corresponding to Bialik's real-life degrees in neuroscience. Is a spokesperson for the Holistic Moms Network and gave birth to her second son at home.

Trivia: Wil Wheaton was eight years old when he got his first showbiz break, appearing with Bill Cosby in a Jell-O pudding commercial. The following year (1982), Wheaton was prominently featured in the voiceover cast of the animated The Secret of NIMH. During this same period, he made his Los Angeles stage debut in a Company of Angels Theatre production of All My Sons. His starmaking turn was as Gordie Lachance, the Stephen King alter-ego, in the 1986 feature Stand By Me (1986). He then went on to play the title role in the 1987 Disney TV-movie Young Harry Houdini. Wheaton gained worldwide fame (and a worldwide website) as ensign Wesley Crusher in the weekly TV series Star Trek: The Next Generation, a role he played from 1987 to 1990. After leaving STNG on his own accord, Wheaton transitioned into adult roles with appearances in Flubber and a slew of independent films, and in 2001 he launched Wil Wheaton Dot Net, a blog that quickly gained a considerable following while turning the veteran actor into something of a geek icon. Meanwhile, in addition to staying busy with voice roles in such popular videogames as the Grand Theft Auto series and Fallout: New Vegas, Wheaton also contributed vocally to such animated television series' as Naruto, Ben 10: Alien Force, and Batman: The Brave and the Bold. In 2009 he began riffing on his own public persona with a recurring role as a fictional version of himself on The Big Bang Theory, and in 2010 he joined the cast of the quirky Sci-fi Channel series Eureka as Dr. Isaac Parrish. The author of both Dancing Barefoot and Just a Geek, Wheaton is the brother of actress Amy Wheaton.

Trivia: A native of Hanham, England, Stephen Merchant shot to fame practically overnight by virtue of his role executive producing the BBC situation comedy blockbuster The Office (2001-2003) with creative partner Ricky Gervais. Born in Bristol, England, in 1974, Merchant enjoyed a brief tenure as a standup comedian and then culled a massive British audience by emceeing his own satirical radio program, The Steve Show, on W963 radio. From 1992 to 1996, the burgeoning comic attended the University of Warwick, where he earned his degree in film and television; he subsequently partnered up with Gervais, and the two attempted to launch a comedy series entitled "Golden Years" on Channel 4 television in the U.K. While that pilot failed to connect with an audience, it prompted the network to give Gervais a spot on the sketch comedy ensemble program The 11 O'Clock Show and paved the way for the duo's success with The Office.The said program premiered in July 2001, and satirized British corporate culture by observing the eccentric doings of the Hough-Wernham paper company's Slough, Berkshire branch. Though the U.K. version of The Office lasted only two seasons, it became an instant sensation, put the names of Gervais and Merchant on the map, and inspired producers Greg Daniels and Ben Silverman to buy the rights to a U.S. remake of the program -- which ran for numerous seasons, culled an untoward number of Emmys, and became one of the highest-rated programs on any network. Gervais and Merchant then created Extras, a satirical comedy about a pair of actors (one played by Gervais, the other by Ashley Jensen) repeatedly working as extras in productions starring famous celebrities. The series featured at least one famous guest star per episode, each a caricatured version of himself or herself. Having previously only played a bit part on The Office, Merchant also took on the supporting role of Darren Lamb, the egregiously incompetent agent of Gervais' character, Andy Millman. The program mirrored the success of its Gervais-Merchant predecessor, and series co-producer HBO quickly picked it up for a run in the United States.Merchant would go on to appear in comedies like The Invention of Lying and Hall Pass, in addition to writing, directing, and appearing in ongoing Gervais collaborations, like Life's Too Short and The Ricky Gervais Show.

Trivia: Studied acting with Uta Hagen. Had a recurring role on The Big Bang Theory starting with its second series, and was promoted to series regular in 2012 for the sixth series. Plays the owner of a comic-book shop in The Big Bang Theory, and once worked at a similar establishment in New York City. Both of his parents are schoolteachers. Has appeared in more than 30 US adverts, including Eggos and FedEx.

Trivia: Began his career as a touring singer and songwriter. Wrote for animated series until getting his big break as a supervising producer for the sitcom Roseanne. Wrote the Deborah Harry 1980s hit "French Kissin' in the USA." Co-composed the soundtrack for the 1980s television series Teenage Mutant Ninja Turtles. Received a star on the Hollywood Walk of Fame in 2009. Four of his shows — The Big Bang Theory, Mike & Molly, Mom and Two and a Half Men — were all in the Top 20 primetime programs during the week of January 27-February 2, 2014. Received an honorary doctoral degree from the State University of New York at Potsdam. Is known for his vanity cards (run during the end credits of his series) in which he shares his thoughts about life.

Trivia: Began his career as a writer for Jim Henson. Was a California gubernatorial candidate in 2003. Worked as a programmer at a software company. Earned a Writer's Guild of America Award for the 1991 tribute special The Muppets Celebrate Jim Henson.

Trivia: For an actor almost universally associated with a single character -- Captain James Tiberius Kirk of the U.S.S. Enterprise -- William Shatner has found diverse ways to stay active in the public eye, even spoofing his overblown acting style in a way far more hip than desperate. Years after he last uttered "warp speed," Shatner remains a well-known face beyond Star Trek conventions, re-creating himself as the spoken-word pitchman for priceline.com, and starring in a popular series of smoky nightclub ads that featured some of the most cutting-edge musicians of the day.The Canadian native was born on March 22, 1931, in Montréal, where he grew up and attended Verdun High School. Shatner studied commerce at McGill University before getting the acting bug, which eventually prompted him to move to New York in 1956. He initially worked in such live television dramatic shows as Studio One and The United States Steel Hour in 1957 and 1958, as well as on Broadway. His big screen debut soon followed as Alexei in the 1958 version of Dostoyevsky's The Brothers Karamazov.Throughout the 1960s, Shatner worked mostly in television. His most memorable appearance came in a 1963 episode of The Twilight Zone entitled "Nightmare at 20,000 Feet," in which he plays a terrified airline passenger unable to convince the crew that there's a mysterious gremlin tearing apart the wing. He also appeared in such films as Judgment at Nuremberg (1961) and the bizarrely experimental Esperanto-language horror film Incubus (1963). In 1966, he got his big break, though neither he nor anyone else knew it at the time. Shatner was cast as the macho starship captain James Kirk on Star Trek, commanding a crew that included an acerbic doctor, a Scottish engineer, and a logician with pointy ears, on a mission "to boldly go where no man has gone before." However, the show lasted only three seasons, considered by many to be high camp. After providing a voice on the even shorter-lived animated series in 1973, Shatner must have thought Star Trek too would pass. A costly divorce and a lingering diva reputation from Star Trek left him with few prospects or allies, forcing him to take whatever work came his way. But in 1979, after a decade of B-movie labor in such films as The Kingdom of Spiders (1977) and a second failed series (Barbary Coast, 1975-1976), Shatner re-upped for another attempt to capitalize on the science fiction series with Star Trek: The Motion Picture. This time it caught on, though the first film was considered a costly disappointment. With dogged determination, the producers continued onward with Star Trek II: The Wrath of Khan (1982), at which point fans finally flocked to the series, rallying behind the film's crisp space battles and the melodramatic tête-à-tête between Shatner and Ricardo Montalban.Shatner had to wrestle with his advancing age and the deaths of several characters in Star Trek II and Star Trek III: The Search for Spock (1984), but by Star Trek IV: The Voyage Home (1986), the actor got to indulge in his more whimsical side, which has since characterized his career. As the series shifted toward comedy, Shatner led the way, even serving as director of Star Trek V: The Final Frontier (1989), which many considered among the series' weaker entries. During this period, Shatner also began parodying himself in earnest, appearing as host of Saturday Night Live in a famous sketch in which he tells a group of Trekkies to "Get a life." He also turned in a wickedly energetic mockery of a moon base captain in Airplane II: The Sequel (1982). Shatner made one final appearance with the regular Star Trek cast in Star Trek VI: The Undiscovered Country (1991), then served as one of the crossovers to the new series of films in Star Trek: Generations (1994), in which endlessly theorizing fans finally learned the fate of Captain Kirk.The success of the Trek movies reenergized Shatner's TV career, even if it didn't immediately earn him more film roles. Shatner played the title role on the successful police drama T.J. Hooker from 1982 to 1987, directing some episodes, then began hosting the medical reality series Rescue 911 in 1989. Shatner returned to the movies with another parody, Loaded Weapon I, in 1993, and in 1994 began directing, executive producing, and acting in episodes of the syndicated TV show TekWar, based on the popular series of Trek-like novels he authored. In the later '90s, Shatner was best known for his humorously out-there priceline.com ads, but also guested on a variety of TV shows, most notably as the "Big Giant Head" on the lowbrow farce Third Rock From the Sun. He also appeared as game show hosts both in film (Miss Congeniality, 2000) and real life (50th Annual Miss America Pageant, 2001). In 1999, Shatner suffered public personal tragedy when his third wife, Nerine, accidentally drowned in their swimming pool. The champion horse breeder and tennis enthusiast owns a ranch in Kentucky and remains active in environmental causes. Shatner took on a small role for 2004's Dodgeball: A True Underdog Story, and voiced the villainous wildebeest Kazar in Disney's animated adventure The Wild in 2006. Shatner returned to television for a starring role on the popular dramady Boston Legal, in which he plays Denny Crane, a once unbeatable lawyer who co-founded the successful law firm where he continues to work despite his reputation as an eccentric old man.

Trivia: The son of a Boston barber, Leonard Nimoy was a star at the age of 8, when he played Hansel in a children's theatre production of Hansel and Gretel. Nimoy remained with his local kiddie theater troupe until 16 (one of his directors during this period was Boris Sagal). After studying drama at Boston College and Antioch College, he took acting lessons from Jeff Corey at the Pasadena Playhouse. In films from 1950, Nimoy played the title character in the low-budget Kid Monk Baroni and essayed bits and minor roles in such productions as Zombies of the Stratosphere (1951), Rhubarb (1951) and Them! (1954). In between acting assignments, he held down a dizzying variety of jobs: soda jerk, newspaper carrier, vacuum-cleaner salesman, vending machine mechanic, pet-shop clerk, cabbie and acting coach. During his 18 months in Special Services at Fort McPherson, Georgia, he acted with Atlanta Theater Guild when he could spare the time. Back in Hollywood in 1956, he became virtually a regular at the Ziv TV studios, playing villains in programs like Highway Patrol and Sea Hunt. For a short while, he specialized in the plays of Jean Genet, appearing in both the stage and film productions of The Balcony and Deathwatch. Impressed by Nimoy's guest turn on a 1963 episode of The Lieutenant, producer Gene Roddenberry vowed to cast the saturnine, mellow-voiced actor as an extraterrestrial if ever given the chance. That chance came two years later, when Roddenberry signed Nimoy to play Vulcanian science officer Spock on Star Trek. At first pleased at the assignment, Nimoy came to resent the apparent fact that the public perceived him as Spock and nothing else: indeed, one of his many written works was the slim autobiography I Am Not Spock. After Star Trek's cancellation, Nimoy joined the cast of Mission: Impossible in the role of "master of disguise" Paris (he replaced the series' previous master of disguise Martin Landau, who ironically had originally been slated to play Spock). In the early 1970s, Nimoy began racking up directorial credits on such series as Night Gallery. He also made his first Broadway appearance in 1973's Full Circle. And, perhaps inevitably, he returned to Spock, thanks to the popular demand engendered by the then-burgeoning Star Trek cult. His initial reacquaintance with the role was as voiceover artist on the 1973 Saturday-morning cartoon version of Star Trek. Then Spock went on the back burner again as Nimoy devoted himself to his theatrical commitments (a touring production of Sherlock Holmes, his one-man show Vincent), his writing and directing activities, and his hosting chores on the long-running (1976-82) TV documentary series In Search Of.... Finally in 1978, Nimoy was back in his Enterprise uniform in the first of several Star Trek theatrical features. The Spock character was killed off in the second Trek picture The Wrath of Khan, but Nimoy stayed with the franchise as director of the next two feature-length Trek entries (PS: Spock also came back to life). He went on to direct such non-Trek filmic endeavors as 3 Men and a Baby (1987), The Good Mother (1988), Funny About Love (1990) and Holy Matrimony (1994). He also produced and acted in the 1991 TV movie Never Forget, and served as executive producer of the 1995 UPN network series Deadly Games. Perhaps because he will always have dozens of professional irons in the fire, Leonard Nimoy now seems resigned to being forever associated with the role that brought him international fame; his most recent autobiographical work was aptly titled I Am Spock. In 2009 he returned to his iconic role portraying Spock in J.J. Abrams smash-hit reboot of the Star Trek franchise. He next took on a recurring role in the sci-fi series Fringe, playing scientist William Bell. Nimoy made a final cameo appearance in Star Trek Into Darkness (2013). He died in 2015, at age 83.

Trivia: Early jobs included high-school teacher and copywriter. Performed with sketch comedy groups Upright Citizens Brigade and Naked Babies. Was a member of New York City punk band Egghead. Starred with a hand puppet in a series of commercials for Ford.