Trivia: For better or worse, leading actor Kelsey Grammer's name will probably forever be associated with the pompous, garrulous, and self-absorbed but lovable psychiatrist Frasier Crane, a character Grammer has played on television since he first appeared on the NBC sitcom Cheers, in 1984, as a love interest for Shelley Long. Though Frasier was not intended to become a series regular, Grammer's performance of the blowhard neurotic charmed audiences and he remained with Cheers through its 1993 demise. At the beginning of the 1993-1994 television season, Grammer's character was resurrected in his own show and moved from Boston to Seattle, where he became a radio psychologist and faced a whole slew of folks just waiting to poke metaphorical pins in his hot air balloon. Thanks to excellent performances and top-notch writing, Frasier became as big a hit as its predecessor. Grammer won three Emmy awards and was nominated for seven more (twice for Cheers, once for his guest appearance on a 1992 episode of Wings, four times for Frasier) for playing the character. Born on St. Thomas, one of the U.S. Virgin Islands, Grammer knew extreme tragedy in youth. Following the shooting death of his father when he was a boy, he was raised in New Jersey and then Florida, by his mother and grandfather. His grandfather died before Grammer became a teen. When he was 20, his sister was abducted and violently murdered. Five years later, he lost two half brothers in a diving accident. As a young man, Grammer found comfort in Shakespeare; with his acting debut in a high school production of The Little Foxes came an interest in pursuing drama as a career. He enrolled in Juilliard, but dropped out after two years to work at San Diego's Old Globe Theater, where he gained three years' invaluable experience performing in Shakespearean and classical dramas; afterward, Grammer performed in productions across the country. He eventually made it to Broadway, where he appeared in various productions, including Othello. Prior to playing Frasier, Grammer appeared occasionally on television and had regular roles in three soap operas, including One Life to Live. He continues to occasionally guest star on other series. Fans of the animated satire The Simpsons will recognize his periodic voice characterization as the venomous Sideshow Bob. Miniseries and telemovies in which he has appeared include London Suite and Beyond Suspicion. Grammer made his feature film debut with a small role in Top of the Hill (1989) and had his first starring role in the much-panned comedy Down Periscope (1996). In addition to his Emmy kudos, Grammer has received an American Comedy Award, two Golden Globes, and a People's Choice Award. In 1995, he published his autobiography So Far.Grammer would spend the following years taking on TV roles on shows like Back to You and Boss, but would find even more success as a producer, helping bring shows like The Game, Girlfriends, Hank, Medium, and World Cup Comedy to fruition. In 2014, he returned to acting in a big way, making a cameo appearance in X-Men: Days of Future Past, reprising his role as Beast, playing the bad guy in Transformers: Age of Extinction, and returning to television in the FX series Partners.

Trivia: Although he is best known for his role as anal-retentive psychiatrist extraordinaire Niles Crane on the celebrated sitcom Frasier, David Hyde Pierce has also done considerable work on the stage and screen. Fair, birdlike, and bearing an uncanny resemblance to Frasier co-star Kelsey Grammer, Pierce is one of the entertainment business' finest purveyors of a certain kind of blue-blooded neuroticism, and, in the eyes of some viewers, has even gone so far as to make insecurity perversely sexy.Born in Saratoga Springs, New York, on April 3, 1959, Pierce was raised in what he has described as a "very run-of-the-mill, middle-class" household. When he was eight, he began taking piano lessons, and he decided to pursue a career as a concert pianist. He continued to train until he got to Yale University, where he realized that he was better suited to the acting profession. Following graduation, Pierce moved to New York and did a brief stint as a tie salesman at Bloomingdale's before being cast in a Broadway play. Although the production was a flop, Pierce continued to work on the stage in New York and Chicago for several years and was eventually cast as a suicidal congressman on the short-lived sitcom The Powers That Be in 1992. His work on the show, coupled with his resemblance to Kelsey Grammer, led to his casting on Frasier the following year.Frasier proved to be the turning point in Pierce's career. His portrayal of Niles, aside from winning him a slew of awards, including an Emmy, also provided a number of opportunities for the actor on the big screen. Pierce, who had been acting sporadically in films since the early '80s, could be seen in supporting roles in such '90s films as Sleepless in Seattle (1993), Nixon (1995), in which he played John Dean, and the animated A Bug's Life (1998), for which he provided the voice of a stick insect.As the first decade of the 21st century opened, Pierce began appearing in more and more feature films, selecting an eclectic array of roles that utitlized his strengths without resorting to rehashing the Niles Crane character. Diverse in their genre and theme, the projects also ranged in their levels of success and acclaim. The 2000 comedy Isn't She Great was an abysmal failure, while the indie films Wet Hot American Summer and Full Frontal both left audiences and critics fiercely split. Pierce also continued to flex his voice skills in the animated features Osmosis Jones and Treasure Planet.One of Pierce's best-received roles came in 2003, when he costarred in the tongue-in-cheek comedy Down With Love. While not much of a box-office hit, the film managed to charm many critics with its wall-to-wall homages to 1960s sex-comedies. A year later, Pierce again showed up sans-body, providing the voice of Abe Sapien in the comic-book adaptation Hellboy. He reunited with Hellboy creator Mike Mignola's animated comic adaptation The Amazing Screw-On Head to voice the role of the dreaded Emperor Zombie in 2006, and joined the cast of The Perfect Host in 2010 for a leading role as Warwick Wilson, whose genteel façade hides a deep rage and mental instability.

Trivia: A distinctive-looking, grey-haired British character actor, John Mahoney worked onstage in his teens, and moved to the U.S. at 19. In his mid-30s, while employed as an editor in Chicago, he decided to renew his interest in acting, and he enrolled in classes at a local theater co-founded by playwright David Mamet; he landed a role in a Mamet play and left his job for the part. At the urging of actor John Malkovich, he went on to join Chicago's celebrated Steppenwolf Theater; eventually he appeared in more than 30 plays. For his work in the Broadway play House of Blue Leaves he won a Tony and a Clarence Derwent Award. For his work in the lead role of Orphans (on Broadway and in Chicago) he won a Theater World Award. He still lives in Chicago, and maintains his connection with Steppenwolf. Mahoney debuted onscreen in Mission HIll (1982), but his screen breakthrough came in his fifth film, Barry Levinson's popular comedy Tin Men (1987); afterwards he went on to better parts in more noteworthy movies, and has avoided typecasting in a busy screen career. Mahoney's TV credits include Favorite Son and House of Blue Leaves, in which he reprised his stage role; he has since achieved wide popularity as Martin Crane, Frasier Crane's crochety father, on the NBC sitcom Frasier.

Trivia: Began studying ballet at a very early age, but hurt her ankle when she was 18 and was forced to give it up. Appeared in David Lee Roth's video for "California Girls." Lived for a time with her best friend Faith Ford, whom she met in acting class. Cofounded the production company Bristol Cities with Frasier costar Peri Gilpin in 1998. Since her first pregnancy wasn't written into Frasier, her character, Daphne, was sent off to a fat camp and was said to have lost 9 pounds, 12 ounces---the weight of Jane's daughter when she was born. Made her Broadway debut in Cabaret as Sally Bowles in 2002. Reunited with Fraiser alum Wendy Malick to costar in the TV Land sitcom Hot in Cleveland.

Trivia: With a father who was a famous local radio and television celebrity, a model mother who appeared in television, and a working relationship with Wings producer Roz Doyle in her past, it may all seem like an obscure cosmic joke that pretty Peri Gilpin would rise to fame as radio producer Roz Doyle on the smash television sitcom Frasier, though the longtime actress would likely credit her success to hard work rather than astrological coincidence.Born in Waco, TX, and raised in Dallas, Gilpin began acting on stage with the Dallas Theater Company at the age of eight, a fact that helped her shake stage fright and gain the confidence that would accompany her through numerous future auditions. A Skyline High School graduate, Gilpin later studied acting at both the University of Texas at Austin and London's British-American Academy. Upon returning to the U.S., Gilpin worked as a makeup artist in the Dallas area before taking an apprenticeship with the Williamstown Theater Festival. A chance meeting with actress Blythe Danner resulted in Gilpin gaining some support within the industry, and it wasn't long before Gilpin's dreams were coming true with roles on television's Flesh 'n' Blood and 21 Jump Street. A role on Cheers followed shortly after, and when a spin-off series entitled Frasier became an unexpected hit, Gilpin found the role that would bring her into households across the country on a weekly basis. Appearing frequently on such made-for-television films as The Secret She Carried (1996) and Laughter on the 23rd Floor (2000) while simultaneously essaying her role on Frasier, Gilpin (who was named after the animated Disney character Peri the squirrel) has also loaned her voice to such animated projects as television's Hercules and the computer-animated feature Final Fantasy: The Spirits Within (2001). Throughout the 2000's and 2010's, Gilpin remained active, starring most notably on the dance series Make It or Break It.

Trivia: Is of American and Canadien descent.Was raised in Indonesia and moved during her childhood to several countries including Nigeria, United Kingdom, and Canada.Moved to Austin, Texas, at the age of 16.Made her debut as an actress in Broadway in the musical Rex.Made her debut as an actress on television in 1979.

Trivia: Although she officially launched her dramatic career on the big screen, with bit parts in Jonathan Demme's nostalgic period piece Swing Shift (1984) and Wes Craven's gore picture The Hills Have Eyes, Part II (1984), African-American actress Penny Johnson (also occasionally credited by her full married name, Penny Johnson Jerald) gained broadest recognition as a network mainstay on innumerable short-lived and long-running U.S. television series. Her presence on the glitter box quickly became so widespread, in fact, that devoted prime-time viewers who fail to connect with Johnson's name will invariably identify her countenance.Born March 14, 1961, in Baltimore, MD, Johnson recognized acting as her life's work while a teenager, and subsequently commenced dramatic training at her home city's Centre Stage Theatre, at age 13, by lying about her age to get in. (She claimed to be 14 -- the ensemble's minimum age requirement.) The ruse worked, and Johnson's success with that troupe encouraged her to subsequently perform in a traveling ensemble (as a mime, juggler, and fire eater) with the Baltimore-based Theatre Project, and attend university for dramatic training at Juilliard several years later. After the aforementioned film roles, Johnson segued into television, first with a brief ongoing role as Debbie on the daytime soap General Hospital (in 1986), then as university law student Vivian on the Showtime pay cable service's revival of the late '70s CBS series The Paper Chase, retitled The Paper Chase: The Second Year (a role she sustained from 1984-1986). After guest spots on such programs as The Jeffersons, Simon & Simon, and Tour of Duty, Johnson landed one of the leads on the very short-lived ABC sitcom Homeroom -- starring as Virginia "Vicki" Harper, the medical-student wife of adman-turned-fourth grade teacher Darryl Harper (Darryl Sivad). That program premiered on September 24, 1989, and wrapped not three months later, unable to find an audience.Johnson then re-teamed with Craven for the director's telemovie Night Visions (1990), about a tough L.A. cop (James Remar) who solicits the help of a psychic (Loryn Locklin) to root out a serial murderer. Craven and co. shot that effort as a pilot for a prospective series, but it never took off. In 1992, the actress returned to pay cable by joining the cast of The Larry Sanders Show, comedian Garry Shandling's HBO satire about the behind-the-scenes shenanigans at a late-night, Carson-style talk program. Johnson struck gold with that move; the show lasted until 1998 and became a massive runaway hit and a critical darling.After small turns in two A-list cinematic releases -- 1993's Tina Turner biopic What's Love Got to Do With It? (as Lorraine) and Rusty Cundieff's 1994 gangsta rap satire Fear of a Black Hat (as Re-Re) -- Johnson carved a permanent niche for herself on three number-one television series, sequentially Star Trek: Deep Space Nine, ER, and 24. In the first, she played Kasidy Yates, a stunningly gorgeous freighter captain who meets and falls in love with Benjamin Sisko, but is indefinitely abandoned by him when he moves into another dimension with The Prophets. She then donned a nurse's uniform for a season (1998-1999) as Lynette Evans at ER's Chicago County General Hospital, alongside co-stars George Clooney, Anthony Edwards, and others, and keyed up for her most prominent role: Sherry Palmer, the wife of Senator David Palmer, and essentially a shrewd, diabolical, Lady Macbeth-like character willing to break any and every moral precept to lock down the presidency of her husband. More recently, Johnson portrayed Secretary of State Condoleeza Rice in the 2003 TV movie DC 9/11: Time of Crisis and again in another TV movie, The Path to 9/11, in 2006. Johnson married her husband, musician Gralin Jerald, in 1982. They have one daughter. In her off time, Johnson is actively involved with her church and with many progressive social causes; she played a significant role in securing aid for victims of Hurricane Katrina.

Trivia: Best known for his role as Dr. George O'Malley on ABC's hit medical drama Grey's Anatomy, T.R. Knight began his acting career on the stage in his hometown of Minneapolis, MN. In the early 2000s, he began appearing in a handful of guest spots on programs ranging from Frasier to Law & Order: Criminal Intent before landing one of the leads on the aforementioned Grey's Anatomy in 2005. Knight left the show af the end of the fifth season, choosing to return to the stage in the 2010 Broadway revival of David Mamet's A Life in the Theatre opposite Patrick Stewart. Knight remained focused on stage work after though, though he did have a recurring role on CBS's legal drama The Good Wife in 2013.

Trivia: Born December 1st, 1970, former Saturday Night Live cast member Sarah Silverman made her film debut in the 1997 Who's the Caboose. She then had a supporting role as a friend of Mary in Peter Farrelly and Bobby Farrelly's 1998 comedy smash There's Something About Mary. Following a part in Chris O'Donnell's The Bachelor, which also starred Renee Zelwegger, Brooke Shields, and James Cromwell, Silverman secured a deal with Columbia Tri-Star to create a vehicle for herself based on her one-woman show, Susan Plays Cheese. She received further exposure on various TV talk shows, as well as in the pages of Esquire Magazine's "breasts" issue and a fashion layout in Mirabella. She appeared in the comedies Screwed and Heartbreakers, and had a memorable role as the driven girlfriend in Richard Linklater's School of Rock. 2005 was a stellar year for Silverman on the big screen. In addition to writing and starring in Sarah Silverman: Jesus Is Magic, she was widely considered to have one of the very best appearances in the documentary The Aristocrats. She followed that up the next year with a part in Todd Phillips' School for Scoundrels. From 2007 to 2009, Silverman played herself in The Sarah Silverman Program, and edgy sitcom that earned the comedienne a nomination for a Primetime Emmy Award. Despite a devoted fan following, Comedy Central cancelled the show after three seasons. In 2008, Silverman appeared semi-regularly on Jimmy Kimmel Live for a series of raunchy sketches involving Matt Damon, and made several appearances on the USA Network's television series Monk. After making a cameo as herself in The Muppets in 2011, Silverman went a different direction by taking on a dramatic role in Take This Waltz, a film following a married couple whose relationship begins to crumble when one half of the pair forms an emotional bond with a neighbor. She next logged a series of voice roles, including Vanellope, a glitchy video game character in Disney's Wreck-It Ralph (2012) and a recurring role on Bob's Burgers. In 2014, she appeared in A Million Ways to Die in the West and began a guest arc on Masters of Sex.

Trivia: Born Andrea Kay Pyle in Houston, TX, a six-month-old Pyle was given the fateful nickname of "Little Missi," which would stick to her throughout her childhood and to the present day. Pyle was infatuated with acting by the age of 13, and attended Germantown High School in Tennessee, one of the top three performing-arts high schools in the United States. While there, Pyle was tapped as a lead singer in several musical productions, though her eventual goal remained a career in television and film. After graduation from Germantown High, Pyle was accepted to the prestigious North Carolina School of the Arts and was cast as the female lead in a series of Shakespearean productions. During the summer, she crossed the Atlantic to attend the Oxford School of Drama in England, where she further honed her acting skills.By 1996, Pyle had made her film debut in The Cottonwood, which followed a group of wannabe actors hoping to use their lottery winnings to score big in Hollywood. Pyle's breakout role, however, wouldn't come until several years later, when she played a supporting role as a love-struck alien in Galaxy Quest alongside Tim Allen and Sigourney Weaver. Though the early 2000s did little to bring Pyle much in the way of mainstream success, they nonetheless helped the actress develop a loyal fan base; her performances in The Wayne Brady Show, Ally McBeal, and Josie and the Pussycats (all 2001) were solid enough to grab the attention of several prominent casting directors. Surely enough, by 2003, Pyle had been chosen for a supporting role in Bringing Down the House with Steve Martin and Queen Latifah, as well as a small but indelible role in Tim Burton's big-budget fantasy comedy Big Fish (2003). In 2004, Pyle worked with Ben Stiller in Along Came Polly and lent her support to Soul Plane and 50 First Dates. Working with Stiller proved a lucky experience for Pyle, who accepted a larger supporting role in Stiller's Dodgeball: A True Underdog Story (2004), which also stars fellow Galaxy Quest alumni Justin Long. When she isn't filming, Pyle continues her work with the all-female sketch comedy group Bitches and Funny.

Trivia: Forever associated with his ongoing voice work as Homer J. Simpson on Matt Groening and James L. Brooks' long, long-running Fox animated sitcom The Simpsons, Dan Castellaneta is well-reputed for his modest, unassuming presence in real life and his paradoxical ability to spin characters -- seemingly from out of nowhere -- that instantly take on lives of their own. Groening once famously remarked that "Dan can do everything, and he practically does....You might never notice him, but then he opens his mouth and he completely creates one character after another.'' Born in 1957, Castellaneta grew up in the small town of Oak Grove, IL, in the northwestern corner of the state, near the Iowa border. As a self-described introvert who developed and honed a facility for slipping into the guise of characters to entertain and make social situations easier (read: class clown), Castellaneta nevertheless diverged from this path in college and worked toward a career as a high-school art teacher via his studies at Northern Illinois University. Then, one of Castellaneta's professors (perhaps sensing some dissatisfaction) wisely admonished him to only work at a field, and in a job, that he loved. Castellaneta reasoned that acting fit the bill, and auditioned for the infamous sketch comedy troupe Second City shortly after graduation. The troupe hired him, and in time, the skills that the actor projected led to his involvement on the then-fledgling Fox network's sketch comedy series The Tracey Ullman Show, which premiered on Sunday, April 5, 1987. Castellaneta joined Ullman, Julie Kavner, Joe Malone, Sam McMurray, and for a time Anna Levine in live-action skits that parodied all aspects of Western culture.As a most unusual aspect of her program, Ullman opted to feature crudely animated, offbeat segments as Monty Python-style transitions between the individual sketches. The episodes in question were drawn by Gabor Csupo and Groening (at that time, comic-strip artist of growing infamy known for his Life Is Hell series starring a buck-toothed, bug-eyed rabbit named Bucky). Although the subjects of the shorts initially varied, within a few months they began to focus exclusively on a hyper-dysfunctional blue-collar family called the Simpsons; Kavner and Castellaneta voiced parents Homer and Marge Simpson, respectively. Those segments gained such massive popularity that they eventually outshone that of the Ullman show itself (which wrapped in September 1990), and executive producer James L. Brooks, following this cue, decided to spin off the Simpsons into their own weekly animated series. Kavner and Castellaneta, of course, followed Brooks to the new program, joined in time by longtime Brooks acquaintance Harry Shearer, as well as Nancy Cartwright, Yeardley Smith, Hank Azaria, and numerous others.The Simpsons premiered on Fox on December 17, 1989, and became not simply a hit but a phenomenon. It shot up to instantly become one of the highest-rated series on television, and attained iconic status. The program scored as a cause célèbre not simply with children (as expected) but with adult viewers as well, who appreciated the show's ability to skewer all aspects of society and culture. (It generated a billion-dollar marketing boom as well -- an onslaught of Bart Simpson-themed T-shirts, watches, dolls, beach towels, and everything else under the sun.) The program also drew an onslaught of celebrity guests -- everyone from Larry King to Tony Bennett to Beverly D'Angelo and Linda Ronstadt. Castellaneta himself will forever be tied to Homer Simpson -- the lunkheaded, potbellied, beer-swilling, donut-loving nuclear-plant worker with not a whole lot upstairs, and a thoroughly crass lifestyle, but also a big, soft heart (a quality which Castellaneta's co-workers insist that he alone brought to the character). But hardcore Simpsons cultists and even its less attentive devotees will realize that Castellaneta voices not only Homer (as mentioned), but also the gravelly voiced, booze-swilling, womanizing clown Krusty; local drunk Barney Gumble; Scottish elementary-school groundskeeper Willie; the octogenarian family patriarch Grampa Simpson; and innumerable others. Certainly, it would be difficult to imagine a program that took fuller advantage of Castellaneta's versatility with characterizations.Alongside The Simpsons, Castellaneta has also pursued a career as a live-action film and television performer, and spent most of the late '80s, '90s, and 2000s vacillating between the two mediums. His career on the big screen began at least a year prior to his involvement with Ullman and co., when he debuted with a bit part as Brian in the now-forgotten Garry Marshall dramedy Nothing in Common (1986), starring Jackie Gleason, Tom Hanks, Eva Marie Saint, and Sela Ward. In 1989, Castellaneta landed bit parts in two wildly different films: one as a maître d' in the Jim Belushi cop comedy K-9, and another (as one of Danny DeVito's clients) in the James L. Brooks-produced jet-black marital farce The War of the Roses. Castellaneta temporarily withdrew from live-action cinematic work in the early '90s, before returning to audiences as the narrator in Super Mario Bros. (1993) and Phil in Warren Beatty's Love Affair (1994). As the Castellaneta's career continued, he then segued into cinematic animated voice-over work (doubtless encouraged by the ongoing success of The Simpsons), doing voices in such features as 2000's Rugrats in Paris (under the aegis of old colleague Gabor Csupo) and Hey Arnold! The Movie (2002). In 2007, Castellaneta extended his Homer characterization to the big screen with his work on The Simpsons Movie -- the first cinematic appearance of Groening's famous animated family.As for television, Castellaneta appeared as a supporting actor in numerous sitcoms during the 1990s. These included ALF (as Steve Michaels in the 1990 episode "Stayin' Alive"), Married...with Children (as Pete in the 1990 episode "The Dance Show"), Wings (as George Wexler in the 1994 episode "Moonlighting"), and Murphy Brown (as Tony Lucchesi in the 1995 episode "Specific Overtures.") He also voiced Genie (inheriting the role from Robin Williams) on the animated Aladdin TV series. Of the Simpsons cast, Castellaneta is one of the only actors to regularly do on-stage comedic improvisation alongside his series work. He is married to Simpsons writer Deb Lacusta, whom he wed in 1987.He continued to work steadily in animated films such as Rugrats in Paris: The Movie and Hey Arnold! The Movie, and landed traditional acting parts every once in a while in movies as diverse as the indie comedy I Want Someone to Eat Cheese With and the Will Smith drama The Pursuit of Happyness. In 2007 he voiced nearly 20 different parts in The Simpsons Movie. He also landed a part in JJ Abrams 2011 Spielberg-influenced family sci-fi film Super 8.

Trivia: British actress Millicent Martin primarily worked on the stage and on television, but she also appeared in a few feature films during the '60s.