Trivia: For better or worse, leading actor Kelsey Grammer's name will probably forever be associated with the pompous, garrulous, and self-absorbed but lovable psychiatrist Frasier Crane, a character Grammer has played on television since he first appeared on the NBC sitcom Cheers, in 1984, as a love interest for Shelley Long. Though Frasier was not intended to become a series regular, Grammer's performance of the blowhard neurotic charmed audiences and he remained with Cheers through its 1993 demise. At the beginning of the 1993-1994 television season, Grammer's character was resurrected in his own show and moved from Boston to Seattle, where he became a radio psychologist and faced a whole slew of folks just waiting to poke metaphorical pins in his hot air balloon. Thanks to excellent performances and top-notch writing, Frasier became as big a hit as its predecessor. Grammer won three Emmy awards and was nominated for seven more (twice for Cheers, once for his guest appearance on a 1992 episode of Wings, four times for Frasier) for playing the character. Born on St. Thomas, one of the U.S. Virgin Islands, Grammer knew extreme tragedy in youth. Following the shooting death of his father when he was a boy, he was raised in New Jersey and then Florida, by his mother and grandfather. His grandfather died before Grammer became a teen. When he was 20, his sister was abducted and violently murdered. Five years later, he lost two half brothers in a diving accident. As a young man, Grammer found comfort in Shakespeare; with his acting debut in a high school production of The Little Foxes came an interest in pursuing drama as a career. He enrolled in Juilliard, but dropped out after two years to work at San Diego's Old Globe Theater, where he gained three years' invaluable experience performing in Shakespearean and classical dramas; afterward, Grammer performed in productions across the country. He eventually made it to Broadway, where he appeared in various productions, including Othello. Prior to playing Frasier, Grammer appeared occasionally on television and had regular roles in three soap operas, including One Life to Live. He continues to occasionally guest star on other series. Fans of the animated satire The Simpsons will recognize his periodic voice characterization as the venomous Sideshow Bob. Miniseries and telemovies in which he has appeared include London Suite and Beyond Suspicion. Grammer made his feature film debut with a small role in Top of the Hill (1989) and had his first starring role in the much-panned comedy Down Periscope (1996). In addition to his Emmy kudos, Grammer has received an American Comedy Award, two Golden Globes, and a People's Choice Award. In 1995, he published his autobiography So Far.Grammer would spend the following years taking on TV roles on shows like Back to You and Boss, but would find even more success as a producer, helping bring shows like The Game, Girlfriends, Hank, Medium, and World Cup Comedy to fruition. In 2014, he returned to acting in a big way, making a cameo appearance in X-Men: Days of Future Past, reprising his role as Beast, playing the bad guy in Transformers: Age of Extinction, and returning to television in the FX series Partners.

Trivia: Although he is best known for his role as anal-retentive psychiatrist extraordinaire Niles Crane on the celebrated sitcom Frasier, David Hyde Pierce has also done considerable work on the stage and screen. Fair, birdlike, and bearing an uncanny resemblance to Frasier co-star Kelsey Grammer, Pierce is one of the entertainment business' finest purveyors of a certain kind of blue-blooded neuroticism, and, in the eyes of some viewers, has even gone so far as to make insecurity perversely sexy.Born in Saratoga Springs, New York, on April 3, 1959, Pierce was raised in what he has described as a "very run-of-the-mill, middle-class" household. When he was eight, he began taking piano lessons, and he decided to pursue a career as a concert pianist. He continued to train until he got to Yale University, where he realized that he was better suited to the acting profession. Following graduation, Pierce moved to New York and did a brief stint as a tie salesman at Bloomingdale's before being cast in a Broadway play. Although the production was a flop, Pierce continued to work on the stage in New York and Chicago for several years and was eventually cast as a suicidal congressman on the short-lived sitcom The Powers That Be in 1992. His work on the show, coupled with his resemblance to Kelsey Grammer, led to his casting on Frasier the following year.Frasier proved to be the turning point in Pierce's career. His portrayal of Niles, aside from winning him a slew of awards, including an Emmy, also provided a number of opportunities for the actor on the big screen. Pierce, who had been acting sporadically in films since the early '80s, could be seen in supporting roles in such '90s films as Sleepless in Seattle (1993), Nixon (1995), in which he played John Dean, and the animated A Bug's Life (1998), for which he provided the voice of a stick insect.As the first decade of the 21st century opened, Pierce began appearing in more and more feature films, selecting an eclectic array of roles that utitlized his strengths without resorting to rehashing the Niles Crane character. Diverse in their genre and theme, the projects also ranged in their levels of success and acclaim. The 2000 comedy Isn't She Great was an abysmal failure, while the indie films Wet Hot American Summer and Full Frontal both left audiences and critics fiercely split. Pierce also continued to flex his voice skills in the animated features Osmosis Jones and Treasure Planet.One of Pierce's best-received roles came in 2003, when he costarred in the tongue-in-cheek comedy Down With Love. While not much of a box-office hit, the film managed to charm many critics with its wall-to-wall homages to 1960s sex-comedies. A year later, Pierce again showed up sans-body, providing the voice of Abe Sapien in the comic-book adaptation Hellboy. He reunited with Hellboy creator Mike Mignola's animated comic adaptation The Amazing Screw-On Head to voice the role of the dreaded Emperor Zombie in 2006, and joined the cast of The Perfect Host in 2010 for a leading role as Warwick Wilson, whose genteel façade hides a deep rage and mental instability.

Trivia: A distinctive-looking, grey-haired British character actor, John Mahoney worked onstage in his teens, and moved to the U.S. at 19. In his mid-30s, while employed as an editor in Chicago, he decided to renew his interest in acting, and he enrolled in classes at a local theater co-founded by playwright David Mamet; he landed a role in a Mamet play and left his job for the part. At the urging of actor John Malkovich, he went on to join Chicago's celebrated Steppenwolf Theater; eventually he appeared in more than 30 plays. For his work in the Broadway play House of Blue Leaves he won a Tony and a Clarence Derwent Award. For his work in the lead role of Orphans (on Broadway and in Chicago) he won a Theater World Award. He still lives in Chicago, and maintains his connection with Steppenwolf. Mahoney debuted onscreen in Mission HIll (1982), but his screen breakthrough came in his fifth film, Barry Levinson's popular comedy Tin Men (1987); afterwards he went on to better parts in more noteworthy movies, and has avoided typecasting in a busy screen career. Mahoney's TV credits include Favorite Son and House of Blue Leaves, in which he reprised his stage role; he has since achieved wide popularity as Martin Crane, Frasier Crane's crochety father, on the NBC sitcom Frasier.

Trivia: Began studying ballet at a very early age, but hurt her ankle when she was 18 and was forced to give it up. Appeared in David Lee Roth's video for "California Girls." Lived for a time with her best friend Faith Ford, whom she met in acting class. Cofounded the production company Bristol Cities with Frasier costar Peri Gilpin in 1998. Since her first pregnancy wasn't written into Frasier, her character, Daphne, was sent off to a fat camp and was said to have lost 9 pounds, 12 ounces---the weight of Jane's daughter when she was born. Made her Broadway debut in Cabaret as Sally Bowles in 2002. Reunited with Fraiser alum Wendy Malick to costar in the TV Land sitcom Hot in Cleveland.

Trivia: With a father who was a famous local radio and television celebrity, a model mother who appeared in television, and a working relationship with Wings producer Roz Doyle in her past, it may all seem like an obscure cosmic joke that pretty Peri Gilpin would rise to fame as radio producer Roz Doyle on the smash television sitcom Frasier, though the longtime actress would likely credit her success to hard work rather than astrological coincidence.Born in Waco, TX, and raised in Dallas, Gilpin began acting on stage with the Dallas Theater Company at the age of eight, a fact that helped her shake stage fright and gain the confidence that would accompany her through numerous future auditions. A Skyline High School graduate, Gilpin later studied acting at both the University of Texas at Austin and London's British-American Academy. Upon returning to the U.S., Gilpin worked as a makeup artist in the Dallas area before taking an apprenticeship with the Williamstown Theater Festival. A chance meeting with actress Blythe Danner resulted in Gilpin gaining some support within the industry, and it wasn't long before Gilpin's dreams were coming true with roles on television's Flesh 'n' Blood and 21 Jump Street. A role on Cheers followed shortly after, and when a spin-off series entitled Frasier became an unexpected hit, Gilpin found the role that would bring her into households across the country on a weekly basis. Appearing frequently on such made-for-television films as The Secret She Carried (1996) and Laughter on the 23rd Floor (2000) while simultaneously essaying her role on Frasier, Gilpin (who was named after the animated Disney character Peri the squirrel) has also loaned her voice to such animated projects as television's Hercules and the computer-animated feature Final Fantasy: The Spirits Within (2001). Throughout the 2000's and 2010's, Gilpin remained active, starring most notably on the dance series Make It or Break It.

Trivia: Though he has played a variety of leading roles, tall, dark, and wholesomely handsome Christopher Reeve will always be the definitive Superman to an entire generation of "Man of Steel" fans. That his definitive character was such a model of physical prowess only serves to intensify the tragedy of Reeve's post-Superman years, marked by a 1995 horseback riding accident that left him almost completely paralyzed.A native of New York City, Reeve was born to journalist Barbara Johnson and professor/writer Franklin Reeve on September 25, 1952. When he was four, his parents divorced, and Reeve and his brother went with their mother to Princeton, NJ, after she married her second husband, a stockbroker. Reeve became interested in acting at the age of eight, an interest that complemented his musical studies at the time. The following year, he made his professional acting debut in a production of a Gilbert and Sullivan operetta at Princeton's McCarter Theater. He would continue to work with the theater through his early teens and further enhanced his resumé at the age of 15, when he received a summer apprenticeship to study drama in Williamstown. The following year, he secured his first agent.Reeve went on to major in English and music at Cornell University. Following his graduation, he pursued a master's degree in drama at Juilliard and then studied under actor John Houseman's tutelage before heading to Europe to work at London's Old Vic and the Comedie Française of Paris. Upon his 1974 return stateside, Reeve took over the role of Ben Harper on the long-running soap opera Love of Life; he stayed with the show through 1978. During this period, he made his Broadway debut, starring opposite Katharine Hepburn in a production of A Matter of Gravity. Though he had made his feature-film debut with a small role in the undersea adventure Gray Lady Down (1977), Reeve did not become a star until he beat out a number of big name actors, including Robert Redford, Sylvester Stallone, and Clint Eastwood, to don the metallic blue body stocking and red cape in Richard Donner's 1978 blockbuster Superman: The Movie. Though the film abounded with exuberant, sly humor, Reeve played his Superman straight, giving him great charm, a touch of irony, and a clumsy wistfulness, thereby creating a believable alien hero who masquerades as a bungling newsman and pines for the love of unknowing colleague Lois Lane. The film was one of the year's most popular and earned Reeve a British Academy Award for Most Promising Newcomer. He went on to reprise the role in the film's three sequels, none of which matched the quality and verve of the original.In a concerted effort to avoid typecasting, Reeve attempted to prove his versatility by essaying a wide variety of roles. In 1980, while Superman II was in production, he returned to Broadway to appear as a gay amputee in Lanford Wilson's Fifth of July. That same year, he also starred in the romantic fantasy Somewhere in Time, playing a Chicago playwright who travels back in time to capture the attentions of a beautiful woman (Jane Seymour). Though generally cast as a good guy, Reeve occasionally attempted darker characters. In Deathtrap (1981), he played a crazed playwright, while he portrayed a corrupt priest in the dismal Monsignor (1982) and a reporter entangled in the prostitution industry in Street Smart (1987). Reeve returned to television in Sleeping Beauty, an entry in Shelley Duvall's distinguished Faerie Tale Theater. He subsequently had success appearing in television movies such as Anna Karenina (1985) and Death Dreams (1992). In the late '80s, Reeve became involved in various social causes and co-founded the Creative Coalition. He was also active with Amnesty International, even going to Chile in 1987 to show support for imprisoned authors. His interest in improving the world is apparent in the earnest but much-panned Superman IV: The Quest for Peace (1987), for which he wrote the story.By the mid-'90s, Reeve was still busy juggling his film, television, and stage work. It all abruptly came to a halt in June 1995, when he fell from a horse during a steeplechase race. Having broken several key bones in his neck, Reeve was left completely paralyzed and could not even breathe without special assistance. The doctors' prognosis for his recovery remained grim, but Reeve still retained hope that advances in medical science would someday allow him to walk again. In 1996, he helped establish the UCI Reeve-Irvine Research Center, which specializes in spinal cord injuries; Reeve's work with the center was indicative of the strength and fortitude he had consistently displayed since his accident. In addition to his offscreen commitments, Reeve continued to work in film and television, making his directorial debut with the critically acclaimed made-for-cable drama In the Gloaming (1997) and starring in the 1998 TV-movie remake of Alfred Hitchcock's Rear Window.Reeve credited much of his post-accident survival to his wife, former cabaret singer Dana Morosini. The two married in 1992, after Reeve separated from Gae Exton. He and Exton -- a modeling executive whom he met while filming the first Superman in England -- never married, but had two children together. He also had a son with Morosini.On October 10, 2004, after years as an outspoken advocate for stem-cell and spinal-cord-injury research, Reeve passed away from heart failure at the age of 52. A year and a half later, his wife Dana died of lung cancer.Prior to their deaths, the Reeves began to develop a pet project, the CG-animated feature Everyone's Hero, with voices by an all-star line-up of performers. The picture told the story of a young boy in the 1930s whose talking bat is stolen by a crooked security guard. It was released in 2007.