Trivia: For better or worse, leading actor Kelsey Grammer's name will probably forever be associated with the pompous, garrulous, and self-absorbed but lovable psychiatrist Frasier Crane, a character Grammer has played on television since he first appeared on the NBC sitcom Cheers, in 1984, as a love interest for Shelley Long. Though Frasier was not intended to become a series regular, Grammer's performance of the blowhard neurotic charmed audiences and he remained with Cheers through its 1993 demise. At the beginning of the 1993-1994 television season, Grammer's character was resurrected in his own show and moved from Boston to Seattle, where he became a radio psychologist and faced a whole slew of folks just waiting to poke metaphorical pins in his hot air balloon. Thanks to excellent performances and top-notch writing, Frasier became as big a hit as its predecessor. Grammer won three Emmy awards and was nominated for seven more (twice for Cheers, once for his guest appearance on a 1992 episode of Wings, four times for Frasier) for playing the character. Born on St. Thomas, one of the U.S. Virgin Islands, Grammer knew extreme tragedy in youth. Following the shooting death of his father when he was a boy, he was raised in New Jersey and then Florida, by his mother and grandfather. His grandfather died before Grammer became a teen. When he was 20, his sister was abducted and violently murdered. Five years later, he lost two half brothers in a diving accident. As a young man, Grammer found comfort in Shakespeare; with his acting debut in a high school production of The Little Foxes came an interest in pursuing drama as a career. He enrolled in Juilliard, but dropped out after two years to work at San Diego's Old Globe Theater, where he gained three years' invaluable experience performing in Shakespearean and classical dramas; afterward, Grammer performed in productions across the country. He eventually made it to Broadway, where he appeared in various productions, including Othello. Prior to playing Frasier, Grammer appeared occasionally on television and had regular roles in three soap operas, including One Life to Live. He continues to occasionally guest star on other series. Fans of the animated satire The Simpsons will recognize his periodic voice characterization as the venomous Sideshow Bob. Miniseries and telemovies in which he has appeared include London Suite and Beyond Suspicion. Grammer made his feature film debut with a small role in Top of the Hill (1989) and had his first starring role in the much-panned comedy Down Periscope (1996). In addition to his Emmy kudos, Grammer has received an American Comedy Award, two Golden Globes, and a People's Choice Award. In 1995, he published his autobiography So Far.Grammer would spend the following years taking on TV roles on shows like Back to You and Boss, but would find even more success as a producer, helping bring shows like The Game, Girlfriends, Hank, Medium, and World Cup Comedy to fruition. In 2014, he returned to acting in a big way, making a cameo appearance in X-Men: Days of Future Past, reprising his role as Beast, playing the bad guy in Transformers: Age of Extinction, and returning to television in the FX series Partners.

Trivia: Although he is best known for his role as anal-retentive psychiatrist extraordinaire Niles Crane on the celebrated sitcom Frasier, David Hyde Pierce has also done considerable work on the stage and screen. Fair, birdlike, and bearing an uncanny resemblance to Frasier co-star Kelsey Grammer, Pierce is one of the entertainment business' finest purveyors of a certain kind of blue-blooded neuroticism, and, in the eyes of some viewers, has even gone so far as to make insecurity perversely sexy.Born in Saratoga Springs, New York, on April 3, 1959, Pierce was raised in what he has described as a "very run-of-the-mill, middle-class" household. When he was eight, he began taking piano lessons, and he decided to pursue a career as a concert pianist. He continued to train until he got to Yale University, where he realized that he was better suited to the acting profession. Following graduation, Pierce moved to New York and did a brief stint as a tie salesman at Bloomingdale's before being cast in a Broadway play. Although the production was a flop, Pierce continued to work on the stage in New York and Chicago for several years and was eventually cast as a suicidal congressman on the short-lived sitcom The Powers That Be in 1992. His work on the show, coupled with his resemblance to Kelsey Grammer, led to his casting on Frasier the following year.Frasier proved to be the turning point in Pierce's career. His portrayal of Niles, aside from winning him a slew of awards, including an Emmy, also provided a number of opportunities for the actor on the big screen. Pierce, who had been acting sporadically in films since the early '80s, could be seen in supporting roles in such '90s films as Sleepless in Seattle (1993), Nixon (1995), in which he played John Dean, and the animated A Bug's Life (1998), for which he provided the voice of a stick insect.As the first decade of the 21st century opened, Pierce began appearing in more and more feature films, selecting an eclectic array of roles that utitlized his strengths without resorting to rehashing the Niles Crane character. Diverse in their genre and theme, the projects also ranged in their levels of success and acclaim. The 2000 comedy Isn't She Great was an abysmal failure, while the indie films Wet Hot American Summer and Full Frontal both left audiences and critics fiercely split. Pierce also continued to flex his voice skills in the animated features Osmosis Jones and Treasure Planet.One of Pierce's best-received roles came in 2003, when he costarred in the tongue-in-cheek comedy Down With Love. While not much of a box-office hit, the film managed to charm many critics with its wall-to-wall homages to 1960s sex-comedies. A year later, Pierce again showed up sans-body, providing the voice of Abe Sapien in the comic-book adaptation Hellboy. He reunited with Hellboy creator Mike Mignola's animated comic adaptation The Amazing Screw-On Head to voice the role of the dreaded Emperor Zombie in 2006, and joined the cast of The Perfect Host in 2010 for a leading role as Warwick Wilson, whose genteel façade hides a deep rage and mental instability.

Trivia: A distinctive-looking, grey-haired British character actor, John Mahoney worked onstage in his teens, and moved to the U.S. at 19. In his mid-30s, while employed as an editor in Chicago, he decided to renew his interest in acting, and he enrolled in classes at a local theater co-founded by playwright David Mamet; he landed a role in a Mamet play and left his job for the part. At the urging of actor John Malkovich, he went on to join Chicago's celebrated Steppenwolf Theater; eventually he appeared in more than 30 plays. For his work in the Broadway play House of Blue Leaves he won a Tony and a Clarence Derwent Award. For his work in the lead role of Orphans (on Broadway and in Chicago) he won a Theater World Award. He still lives in Chicago, and maintains his connection with Steppenwolf. Mahoney debuted onscreen in Mission HIll (1982), but his screen breakthrough came in his fifth film, Barry Levinson's popular comedy Tin Men (1987); afterwards he went on to better parts in more noteworthy movies, and has avoided typecasting in a busy screen career. Mahoney's TV credits include Favorite Son and House of Blue Leaves, in which he reprised his stage role; he has since achieved wide popularity as Martin Crane, Frasier Crane's crochety father, on the NBC sitcom Frasier.

Trivia: Began studying ballet at a very early age, but hurt her ankle when she was 18 and was forced to give it up. Appeared in David Lee Roth's video for "California Girls." Lived for a time with her best friend Faith Ford, whom she met in acting class. Cofounded the production company Bristol Cities with Frasier costar Peri Gilpin in 1998. Since her first pregnancy wasn't written into Frasier, her character, Daphne, was sent off to a fat camp and was said to have lost 9 pounds, 12 ounces---the weight of Jane's daughter when she was born. Made her Broadway debut in Cabaret as Sally Bowles in 2002. Reunited with Fraiser alum Wendy Malick to costar in the TV Land sitcom Hot in Cleveland.

Trivia: With a father who was a famous local radio and television celebrity, a model mother who appeared in television, and a working relationship with Wings producer Roz Doyle in her past, it may all seem like an obscure cosmic joke that pretty Peri Gilpin would rise to fame as radio producer Roz Doyle on the smash television sitcom Frasier, though the longtime actress would likely credit her success to hard work rather than astrological coincidence.Born in Waco, TX, and raised in Dallas, Gilpin began acting on stage with the Dallas Theater Company at the age of eight, a fact that helped her shake stage fright and gain the confidence that would accompany her through numerous future auditions. A Skyline High School graduate, Gilpin later studied acting at both the University of Texas at Austin and London's British-American Academy. Upon returning to the U.S., Gilpin worked as a makeup artist in the Dallas area before taking an apprenticeship with the Williamstown Theater Festival. A chance meeting with actress Blythe Danner resulted in Gilpin gaining some support within the industry, and it wasn't long before Gilpin's dreams were coming true with roles on television's Flesh 'n' Blood and 21 Jump Street. A role on Cheers followed shortly after, and when a spin-off series entitled Frasier became an unexpected hit, Gilpin found the role that would bring her into households across the country on a weekly basis. Appearing frequently on such made-for-television films as The Secret She Carried (1996) and Laughter on the 23rd Floor (2000) while simultaneously essaying her role on Frasier, Gilpin (who was named after the animated Disney character Peri the squirrel) has also loaned her voice to such animated projects as television's Hercules and the computer-animated feature Final Fantasy: The Spirits Within (2001). Throughout the 2000's and 2010's, Gilpin remained active, starring most notably on the dance series Make It or Break It.

Trivia: As the son of multi-talented comedic genius Carl Reiner (Your Show of Shows), Rob Reiner instantly outgrew his father's legacy to establish himself as an independent force in multiple facets of the entertainment industry. Born in the Bronx in 1945, Reiner moved to Los Angeles with his folks at the age of 12 (not coincidentally, the very same year that the NYC-based Caesar's Hour, with Carl Reiner as a regular contributor, wrapped) and soon began acting in regional theater and improv ensembles. After appearing on various episodes of Alfred Hitchcock Presents from the age of 16 and studying drama at UCLA, Reiner co-founded the improvisational comedy troupe The Session, then made his onscreen cinematic debut in his father's Enter Laughing (1967) and contributed scripts (in his dad's vein) to CBS's controversial The Smothers Brothers Comedy Hour. His first massive break arrived when he landed the role of Mike "Meathead" Stivic, the liberal, Polish son-in-law to Carroll O'Connor's racist working stiff Archie Bunker, on Norman Lear's groundbreaking network hit All in the Family. In 1971, Reiner wed Penny Marshall (the sister of another comic demagogue, Garry Marshall); the marrieds frequently appeared together on ABC's The Odd Couple. Reiner earned two Emmys for All in the Family, but ended his role in 1978 (after seven seasons) as the series transitioned into Archie Bunker's Place. A now-forgotten telemovie followed -- the romantic comedy More Than Friends, written by and starring Reiner and Marshall (and directed by future Cheers progenitor James Burrows) -- but by that point, the Reiners' marriage was in disarray; a divorce ensued in 1979, followed by several years of inactivity on Reiner's end.Reiner bounced back as a director, however (and then some) in 1984, with the hysterical mockumentary This Is Spinal Tap, ostensibly a spoof of The Song Remains the Same, The Kids Are Alright, The Last Waltz, and other mid-'70s concert films, about a gleefully moronic glam rock band (Christopher Guest, Michael McKean, and Harry Shearer) whose hits include "Sex Farm," "Smell the Glove," and "Hellhole." The picture became a sensation (a massive cult hit), led to several Reiner-less follow-ups with the principal cast (Waiting for Guffman, Best in Show, A Mighty Wind), and -- most importantly -- launched Reiner as a directorial force. He helmed a cute and charming sophomore effort, the teen comedy The Sure Thing (1985), which boasts two superb lead performances by John Cusack and Daphne Zuniga, and demonstrates great taste and sensitivity, but failed to make a splash despite solid reviews (Roger Ebert declared it "a small miracle" and Variety assessed it as "sweetly old fashioned" and "appealing.") The following year, the director struck box-office gold with his third effort, Stand by Me (1986). In this coming-of-age saga, adapted from a Stephen King short story by Ray Gideon and Bruce A. Evans, Reiner successfully blends comedy, drama, and sentiment, and elicits exemplary performances from an ensemble of teenage performers including River Phoenix and Wil Wheaton, in his story of a bunch of adolescent boys who venture out to find a local boy's corpse. For his fourth effort, Reiner helmed the legendary William Goldman's adaptation of his own 1973 fantasy novel, The Princess Bride (which had purportedly floated around Hollywood for 13 years), and scored in the process -- especially with young viewers, who immediately warmed to Cary Elwes' dashing adventurer and Robin Wright's heroine. (The picture's neat comic turns by Billy Crystal, Wallace Shawn, and Andre the Giant stretched its appeal to older viewers, as well.) Reiner followed this up with another four-star blockbuster, and one of the most lucrative (and affable) pictures of 1989, the romantic comedy When Harry Met Sally, written by Nora Ephron. It sports exceptional lead performances by Crystal and Meg Ryan, and -- in one of the most infamous movie bits of the past few decades, a cameo by Reiner's own mother, Estelle, who provides the film's funniest line.Reiner began the 1990s with another Stephen King outing: Misery, a claustrophobic horror picture adapted from a 1987 King novel. In directing the picture, Reiner elicited exceptional performances from James Caan and Kathy Bates. The latter won a Best Actress Academy Award for her portrayal of the psychopathic ex-nurse Annie Wilkes, who confines Caan's author in her home and forces him to write a new manuscript under the duress of torture and threatened homicide. With a trio of A-list actors including Jack Nicholson, Tom Cruise, and Demi Moore, the director's late 1992 courtroom thriller A Few Good Men (adapted by Aaron Sorkin from his play) earned a Best Picture Oscar nomination and another Golden Globe nomination for Reiner. Unfortunately, this marked the beginning of a decline, of sorts, for Reiner. He then helmed 1994's god-awful family-friendly comedy North (reviled by just about everybody). The following year's The American President charmed audiences, but 1996's Ghosts of Mississippi struck most viewers as uneven. In 1999, Reiner produced, directed, and co-starred in The Story of Us, a romantic comedy starring Michelle Pfeiffer and Bruce Willis, but it opened up to mediocre reviews. (Ebert gave it one star and moaned, "Watching it is like taking a long trip in a small car with the Bickersons"; Janet Maslin observed that it "offers such an arthritic vision of middle-aged marriage that it feels like the first Jack Lemmon comedy made expressly for the baby-boom generation.") Perhaps riled by these disappointments -- and seeking greater immersion in California politics -- Reiner took several years off as a director, until 2003's Alex & Emma, a romantic comedy about writer's block starring Luke Wilson and Kate Hudson. With one or two exceptions, critics universally panned the picture (giving Reiner his most terrible reviews to date). 2005's Rumor Has It..., yet another romantic comedy starring Jennifer Aniston as a woman who goes off in search of her family's roots, also opened to dismal reviews and lackluster box office, despite the star appeal of Aniston and her male lead, Kevin Costner. In 1987, Reiner co-founded Castle Rock Productions (the company's name refers to a fictional town created by Stephen King). In addition to directing and producing, Reiner has also pursued an acting career on the side, with supporting roles and cameos in such films as Postcards From the Edge (1990), Sleepless in Seattle (1993), Bullets Over Broadway (1994), The First Wives Club (1996), Primary Colors (1998), EDtv (1999), The Muse (1999), The Story of Us (1999), and The Majestic (2001). Later, he delivered a performance as Wirschafter in his own Alex & Emma (2003) and cameo'd as himself in the 2003 David Spade comedy Dickie Roberts: Former Child Star. Between 2004 and 2006, Reiner joined Whoopi Goldberg, Mandy Patinkin, William H. Macy, and others to voice the late Christopher Reeve's CG-animated feature Everybody's Hero, about a boy who attempts to retrieve a talking baseball bat from a crooked security guard. In 2007 he had one of his biggest late-career successes directing Jack Nicholson and Morgan Freeman in The Bucket List. Three years later he made the little-seen comedy Flipped. Reiner married his second wife, Michele Singer Reiner, in 1989.