San Francisco 49ers (8-4) at Cleveland Browns (3-8). From Huntington Bank Field. Wintry conditions and a thriving Browns defense (273 ypg allowed) led by Myles Garrett await QB Brock Purdy and the surging 49ers, who are bidding for their first win in Cleveland since 1984. Rookie QB Shedeur Sanders makes his second start for Cleveland, with top WR Jerry Jeudy (1 TD) eager to find the end zone.