Trivia: Animation pioneer Seth MacFarlane followed in the footsteps of Matt Groening, Trey Parker, and Matt Stone, and others by creating (at age 25!) one of the top-tiered animated series on national television. Family Guy, which debuted in 1999, preserved the sitcom-family premise of The Simpsons but upped the irreverence quotient tenfold (defying many who regarded such an accomplishment as impossible), meanwhile tossing in dozens upon dozens of off-the-cuff (and frequently risqué) references to pop culture -- citing everything from Oz to The Wizard of Oz, The $25,000 Pyramid to songs by a-ha, and thus seizing upon instant identification with Gen-X and Gen-Y viewers. Episodes, which began mundanely enough, could immediately segue, without advance notice, into music video-style montages, game-show sequences, multi-character musical production numbers, mock historical sequences, etc. The basic premise revolved around the nutty Griffin clan of Quahog, Rhode Island: obese toy manufacturer dad Peter; neurotic housewife Lois; ne'er-do-well, dim-bulb 13-year-old son Chris; the angst-ridden 16-year-old daughter Meg, and -- what really made the series bizarre and original -- Stewie, a one-year-old infant with a massive head, a genius IQ, and the verbal erudition of Rex Harrison.Family Guy found a sizeable audience and lasted for many seasons, yet reportedly suffered from a tumultuous history at Fox, where it endured repeat cancellations, numerous rerun episodes, and reemergence on different networks and in different time slots, meanwhile becoming a cult hit on DVD. In the interim, MacFarlane branched out into another animated sitcom, American Dad (2005). Family Guy eventually gained extremly solid ground, however, and soon spawned a spin-off, The Cleveland Show.

Trivia: Actress Wendy Schaal made her feature-film debut in the teen comedy Records (1978). She subsequently went on to have a sporadic film career, the highlights of which include Innerspace (1987) and The 'Burbs (1989). Though she worked steadily through the 1990s, she disappeared from screens in the 21st century, making a triumphant comeback voicing Francine Smith on the FOX animated sitcom American Dad!

Trivia: Former adolescent actor Scott Grimes first appeared onscreen at age 15 in Critters (1986).

Trivia: The younger sister of Family Guy and American Dad creator Seth MacFarlane, Rachael MacFarlane has provided a number of voices on her famous sibling's animated sitcom Family Guy, and the voice of Hayley Smith, a regular character on American Dad. Additional achievements of hers include voices for Johnny Bravo, Dexter's Laboratory, and The Grim Adventures of Billy & Mandy.

Trivia: American voice artist, standup comedian, and singer Dee Bradley Baker started gaining experience at age nine in all forms of theatrical production, including musical comedies, operas, and nonmusical plays. After college, Baker moved to Los Angeles and quickly established himself as a highly regarded voice actor on animated series, specials, and features. Baker demonstrated a particularly strong aptitude for various ethnic dialects, as well as animal, extraterrestrial, and monster characters. He voiced Louie in the 2000 feature The Trumpet of the Swan, contributed zombie moans to the 2004 Dawn of the Dead remake, and voiced creatures in small-screen programs such as Avatar: The Last Airbender, SpongeBob SquarePants, and Codename: Kids Next Door. Baker was also particularly memorable as Klaus, a talking fish with a massive libidinal drive, on the Seth MacFarlane animated series American Dad. In addition to his extensive film and television credits, Baker's vocal contributions to such popular video games as Left 4 Dead 2, Batman: The Brave and the Bold, Star Wars: The Force Unleashed II, and Diablo III helped to make him one of the busiest voice actors in Hollywood.

Trivia: Does extensive voice-over work, including voicing Cosmo on The Fairly OddParents and J. Jonah Jameson on The Spectacular Spider-Man. Played public defender Cliff McCormack on three seasons of Veronica Mars. Cast as one of the few adult characters, Gordy the Janitor, on Nickelodeon's Ned's Declassified School Survival Guide.