Trivia: Born on a Belgian army base, curly brown-haired Johnny Galecki grew up in Chicago and started acting professionally at the age of 12. He made his feature film debut in 1988 as River Phoenix's little brother in A Night in the Life of Jimmy Reardon. He then assumed the role of Rusty Griswold in National Lampoon's Christmas Vacation, and gained his first regular role on a TV series as Robert Ulrich's son in American Dreamer. In 1991, he starred in the made-for-TV movie Backfield in Motion, co-starring the production team of Roseanne and Tom Arnold. The next year, Galecki joined the cast of Roseanne as Darlene's sensitive and put-upon boyfriend David Healy. He stayed on the show until its final season in 1997, although he wasn't on very much during its last few years. His other television credits include several guest appearances, leading roles in made-for-TV movies, and a part on the short-lived Head of the Class spin-off Billy. After Roseanne ended, he got back into features with small parts in I Know What You Did Last Summer, Bean, and Suicide Kings. He continued playing slightly effeminate sensitive males in The Opposite of Sex and Morgan's Ferry. After bit parts in Bounce, Playing Mona Lisa, and Vanilla Sky, Galecki played a leading role in the comedy thriller Bookies, which premiered at the 2003 Sundance Film Festival. In 2007 he landed the leading role in the sitcom The Big Bang Theory and it grew to be one of the most popular shows on TV, earning Galecki Emmy, Golden Globe, and Sag nominations in 2011 for his work on the show. He maintained his movie career in projects such as Hancock and In Time.

Trivia: Kaley Cuoco began modeling and acting at the tender age of six, when she was cast in the TV movie Quicksand: No Escape. Growing up in front of the camera, the young actress continued to appear as the requisite little girl in movies like Virtuosity and Picture Perfect until she was cast as teenage daughter Bridget on the sitcom 8 Simple Rules. TV would prove to be the actor's bread and butter, and she would go on to star on Charmed, 6Teen, and Monster Allergy, not to mention The Big Bang Theory, a show that earned her legions of fans as Penny, the hot neighbor of two geeky physicists (Johnny Galecki, Jim Parsons). Cuoco also continued to appear in films, though on a much smaller scale compared to her TV work. She appeared in a supporting role in the Easter film Hop in 2011, and played the female lead opposite Kevin Hart and Josh Gad in The Wedding Ringer in 2015.

Trivia: Though initially typecast in comedic roles -- including a small turn in Old School (2003), a contribution to Tracey Ullman in The Trailer Tales (2003), and work on MADtv -- American character actor Simon Helberg quickly branched out into diverse genres. He appeared as a CBS page in George Clooney's revered Edward R. Murrow biopic Good Night, and Good Luck., as a junior agent in Christopher Guest's For Your Consideration (2006), and in a recurring role on the Aaron Sorkin comedy drama Studio 60 on the Sunset Strip. In 2007, Helberg was cast in the regular role of Howard Wolowitz on the sitcom The Big Bang Theory, about a couple of nerdy physicists (Johnny Galecki and Jim Parsons) who struggle with women, and everything else outside the lab. In 2007, Helberg also made appearances in the comedies Mama's Boy and Walk Hard: The Dewey Cox Story. He played a young rabbi in the Coen brothers film A Serious Man (2009), and continued to make guest appearances on TV shows such as Kick Buttowski: Suburban Daredevil and Drunk History, while maintaining his regular status on The Big Bang Theory.

Trivia: Actor Kunal Nayyar first made a splash in Hollywood playing physicist Koothrappali on the series The Big Bang Theory, which debuted on CBS in 2007. In 2012 Nayyar voiced the character of Gupta in Ice Age: Continental Drift, and the following year he could be seen opposite Gina Gershon and Billy Campbell in the thriller, The Scribbler. In addition to his feature work Nayyar also co-wrote the critically acclaimed play Cotton Candy, which runs in New Delhi.

Trivia: Name means "water" in Hebrew. Had her big break in the 1988 film Beaches, playing the younger version of Bette Midler. Appeared in the music video for Michael Jackson's "Liberian Girl." Made her television debut in the 1980s fantasy series Beauty and the Beast. Best known for her role as the title character in the sitcom Blossom. Was successful in many voiceover roles in animated series, including Kim Possible and Hey Arnold! Appeared on a 2009 episode of What Not To Wear. Her The Big Bang Theory character, Amy Farrah Fowler, is a neurobiologist, corresponding to Bialik's real-life degrees in neuroscience. Is a spokesperson for the Holistic Moms Network and gave birth to her second son at home.

Trivia: Began her career as a comedian and had a one-woman show, The Miss Education of Jenna Bush, in which she played the daughter of former president George W. Bush. Co-wrote, directed and starred in the comedic short The Condom Killer. Toured with the political-satire group Gross National Product. Performs with The Realest Real Housewives show, in which comedians read transcripts from the Real Housewives franchise. Was a recurring guest star on series 3 of The Big Bang Theory before joining the cast as a series regular in series 4.

Trivia: Studied acting with Uta Hagen. Had a recurring role on The Big Bang Theory starting with its second series, and was promoted to series regular in 2012 for the sixth series. Plays the owner of a comic-book shop in The Big Bang Theory, and once worked at a similar establishment in New York City. Both of his parents are schoolteachers. Has appeared in more than 30 US adverts, including Eggos and FedEx.

Trivia: Matriculating from Illinois State University, actress Laurie Metcalf was one of the charter members of Chicago's groundbreaking Steppenwolf Theatre troupe. She moved on to New York in the early '80s, winning a 1984 Theatre World Award and an Obie for her performance in Balm in Gilead. In films since 1985, the flexible Metcalf has been seen in director Susan Seidelman's Desperately Seeking Susan (1985) and Making Mr. Right (1987), and also in several other highly regarded productions, notably Uncle Buck (1989), JFK (1991), and Mistress (1992). Metcalf is best known to the TV-watching public for her Emmy-winning portrayal of Roseanne Conner's police-officer sister, Jackie Harris, on the long-running sitcom Roseanne. In 1997, following the demise of her television series, Metcalf turned in a deliciously over-the-top performance as the tightly wound aspiring reporter Debbie Salt in Scream 2. In the decades to come, Metcalfe would find success on shows like Norm and The Big Bang Theory, as well as movies like Stop-Loss Georgia Rule. Despite her hectic schedule, Laurie Metcalf still finds time for an occasional return-to-the-womb appearance at the Steppenwolf Theatre, usually in the company of fellow Steppenwolfians John Malkovich, Gary Sinise, and/or Glenne Headly.

Trivia: Actress Kathy Bates has been involved in the arts in one way or another since graduating from Southern Methodist University. Among the Memphis native's earliest jobs were a stint as a singing waitress in a Catskill resort and a sojourn as a gift shop cashier in New York's Museum of Modern Art. Bates was type-cast in character roles early on, which assured her a lot more work than the thousands of faceless ingenues in the business. Her film debut occurred with 1971's Taking Off, and she made her off-Broadway debut five years later in Vanities.For a long while, Bates made her name on the stage, only to see her roles go to other actresses in the plays' subsequent film adaptations. In 1983, she was nominated for a Tony award for her stage appearance as a garrulous would-be suicide in 'Night, Mother, a role played on screen by Sissy Spacek. She also appeared as Lenny McGrath in Beth Henley's Pulitzer Prize-winning play Crimes of the Heart, a role played on screen by Diane Keaton. And in 1987, playwright Terrence McNally wrote a part specifically tailored to Bates' talents: the much-abused waitress Frankie in Frankie and Johnny in the Clair de Lune, a role which won her an Obie award, and, following a familiar pattern, was played on screen by Michelle Pfeiffer.Bates finally got to star in a movie herself in 1990. And what a starring role it was: in Misery, she portrayed the psychotic "Number One Fan" of romance writer Paul Sheldon (James Caan), a searing performance which earned the actress an Academy Award and a Golden Globe. Appropriately enough, Hollywood screenwriters subsequently began making more room for Bates in their scripts. She worked steadily throughout the rest of the decade in films of greatly varying quality. Particular highlights included Fried Green Tomatoes (1991), A Prelude to a Kiss (1992), Dolores Claiborne (1995), Titanic (1997), and Primary Colors (1998), the latter of which featured Bates giving an Oscar and Golden Globe nominated performance as a political muckraker. Following her firey, foul-mouthed performance in that thinly veilied political biopic, Bates added a new credential to her resume, that of director. Initially taking the helm for the made-for-cable feature Dash and Lilly, Bates would subsequently direct episodes of the quirky HBO drama series Six Feet Under, simultaniously taking minor film roles before returning to more substantial roles with the CBS Hallmark Hall of Fame entry My Sister's Keeper. Roles in Love Liza and Dragonfly (both 2002) were soon to follow, and with her turn as an extroverted mother who catches the attention of Jack Nicholson in About Schmidt Bates would recieve her third Oscar nomination.She directed a number of episodes of the HBO series Six Feet Under before joining the cast in season 3 as Bettina. The next year she portrayed Queen Victoria in the big-budget remake of Around the World in 80 Days. She directed he feature Ambulance Girl in 2005. She continued to act steadily in a variety of projects including Failure to Launch, P.S. I Love You, Fred Claus, Bee Movie, and Revolutionary Road. She provided expert support for Sandra Bulock as the younger actress was winning an Oscar in The Blind Side, and Bates joined the cast of The Office in 2009. She was part of the large ensemble in 2010'ss Valentine's Day, and in 2011 starred as Gertrude Stein in Woody Allen's Oscar winning Midnight in Paris. That same year she launched her own network Drama series Harry's Law.

Trivia: When Mark Hamill accepted the role of Luke Skywalker in George Lucas' Star Wars trilogy, he had no idea that he was going to become a cultural icon of callow youth, raw courage, and true heroism. Hamill was born the son of a naval captain, one of nine brothers and sisters. Hamill spent much of his youth traveling to different bases in the U.S. and Japan. He was studying drama at Los Angeles City Drama when he landed his first professional acting role as a guest star on the television series The Bill Cosby Show. Between 1972 and 1973, Hamill played Kent Murray on the television soap General Hospital and also did guest appearances on other television shows and in TV movies. In 1974, Hamill co-starred in The Texas Wheelers, a down-home sitcom that only lasted a season. He made his screen debut in Star Wars (1977) and became such a big hit that he had trouble getting other types of roles. Shortly before the release of Star Wars, Hamill was involved in a terrible car crash that resulted in surgeons having to reconstruct his face. Despite the enormity of Hamill's popularity in this film, he was unable to attain a lucrative film career like his co-star, Harrison Ford, perhaps because he too closely identified with Luke in viewers' minds to be seen as anyone else. Instead, Hamill appeared in films such as Corvette Summer (1978), The Big Red One (1980), and The Night the Lights Went Out in Georgia (1980). Hamill tried his luck on and off-Broadway and won excellent reviews for his work, playing the leads in The Elephant Man and Amadeus. By the 1990s, he had largely been cast in direct-to-video ventures. On television, he provided his voice to at least two animated characters in The Adventures of Batman and Robin. In addition, Hamill starred in several hit CD-ROM games in the Wing Commander series and continues to appear occasionally on television. Finally, Hamill and his cousin, Eric Johnson, co-wrote The Black Pearl comic book series, which Hamill hopes to make into an animated movie.He became famous for voicing The Joker in the animated Batman series, and spoofed his own celebrity with a memorable cameo in Kevin Smith's Jay & Silent Bob Strike Back. He continued to find steady work in animated projects like Futurama, Robot Chicken, Danger Ranger, and even Scooby-Doo.

Trivia: Wil Wheaton was eight years old when he got his first showbiz break, appearing with Bill Cosby in a Jell-O pudding commercial. The following year (1982), Wheaton was prominently featured in the voiceover cast of the animated The Secret of NIMH. During this same period, he made his Los Angeles stage debut in a Company of Angels Theatre production of All My Sons. His starmaking turn was as Gordie Lachance, the Stephen King alter-ego, in the 1986 feature Stand By Me (1986). He then went on to play the title role in the 1987 Disney TV-movie Young Harry Houdini. Wheaton gained worldwide fame (and a worldwide website) as ensign Wesley Crusher in the weekly TV series Star Trek: The Next Generation, a role he played from 1987 to 1990. After leaving STNG on his own accord, Wheaton transitioned into adult roles with appearances in Flubber and a slew of independent films, and in 2001 he launched Wil Wheaton Dot Net, a blog that quickly gained a considerable following while turning the veteran actor into something of a geek icon. Meanwhile, in addition to staying busy with voice roles in such popular videogames as the Grand Theft Auto series and Fallout: New Vegas, Wheaton also contributed vocally to such animated television series' as Naruto, Ben 10: Alien Force, and Batman: The Brave and the Bold. In 2009 he began riffing on his own public persona with a recurring role as a fictional version of himself on The Big Bang Theory, and in 2010 he joined the cast of the quirky Sci-fi Channel series Eureka as Dr. Isaac Parrish. The author of both Dancing Barefoot and Just a Geek, Wheaton is the brother of actress Amy Wheaton.

Trivia: Like Henry Thomas and a few others of the same generation, Jerry O'Connell proves that second acts are far from impossible for Hollywood actors who began their careers as children. O'Connell first gained recognition among film fans as "that fat kid from Stand By Me," when he starred in the 1986 Rob Reiner film at the age of eleven - then experienced a massive physical transformation. Several years and many lost pounds later, O'Connell emerged as a tall, handsome screen lothario, a development that provoked substantial commentary from both film critics and any number of lay viewers.Born in New York City on February 17, 1974, O'Connell enrolled in acting classes at the age of six. He obtained his first professional assignments acting in commercials when he was ten, and a year later made his film debut in the critically acclaimed Stand By Me. Though somewhat overshadowed by the presence of teen idol co-stars River Phoenix and Corey Feldman, O'Connell still managed to win a place in the coming-of-age pantheon. After Stand By Me, he appeared in the memorable syndicated television series My Secret Identity (as a high schooler with superpowers) and enrolled at Manhattan's Professional Children's School. Following his graduation, he attended New York University, where he attained a B.A. in Film and Television in 1995. While still an NYU student, O'Connell appeared in the eminently forgettable Jason Priestley vehicle Calendar Girl (1993).After his college graduation, O'Connell began to pursue thesping full-time. He soon landed a starring role on the sci-fi series Sliders, which, despite low ratings, had a very loyal viewership. In 1996, the actor's popularity grew beyond the confines of television when he starred in both Joe's Apartment and Jerry Maguire. The latter film was a particular success, and O'Connell began to land steady film assignments once again. Next up was the slasher movie Scream 2 (1997), in which he played Neve Campbell's boyfriend. After an uncredited role in the Jennifer Love Hewitt vehicle Can't Hardly Wait (1998), O'Connell returned to television to star as a young Vietnam War soldier in the miniseries The '60s in 1999. That same year, he starred as a neanderthal-like jock in Body Shots, a film about the search for love and/or a lay amongst a group of Los Angeles twentysomethings.At this point, if O'Connell still carried a full resume, he often seemed to alternate between respectable A-list material - such as the disappointing but ambitious Brian De Palma sci-fi'er Mission to Mars (2000) and the generally pleasant family comedy Yours, Mine and Ours (2005) - and ridiculous studio dreck, such as the misogynistic sex comedy Tomcats (2001) and the awful 2002 "family" picture Kangaroo Jack (where the actor co-starred alongside a wisecracking CG-animated marsupial). In fall 2007, O'Connell trekked back to the small screen for one of the three lead roles in the sitcom Carpoolers - about a cadre of male buddies who share rides to and from work each day. O'Connell would spend the next few years appearing in movies like Obsessed and Piranha, in addition to successful TV runs like Do Not Disturb and The Defenders.O'Connell married supermodel and actress Rebecca Romijn in 2007. The two have two children.

Trivia: Worked as a Latin teacher in a New Jersey high school before starting his career as a magician. Was a guest narrator for the Broadway production of The Rocky Horror Picture Show in 2001. In 2001, was awarded the Hefner First Amendment Award from the Playboy Foundation along with Penn Jillette for their work to defend free speech. Directed a stage production of Macbeth that toured the East Coast of the U.S. Is the co-author several New York Times best-selling books written with Penn Jillette, and is the author of When I'm Dead All This Will Be Yours. In April 2013, was honored with a star on the Hollywood Walk of Fame.

Trivia: Early jobs included high-school teacher and copywriter. Performed with sketch comedy groups Upright Citizens Brigade and Naked Babies. Was a member of New York City punk band Egghead. Starred with a hand puppet in a series of commercials for Ford.

Trivia: Best known for his trademark deadpan delivery and behind-the-mic evocations of the stoner mentality, Sacramento-born stand-up comedian, character actor, and television mainstay Brian Posehn graduated from Sonoma Valley High School in 1984 before cultivating his schtick at age 21 as a "road comic" in contests across the country and with appearances on MTV's 1/2 Hour Comedy Hour. Many small-screen turns followed, including bit parts on Seinfeld (as Artie, a patient in the episode where Kramer "contracts" gonorrhea) and Friends. In two roles with a slightly higher profile, Posehn joined the Mr. Show sketch comedy troupe on HBO and became a periodic fixture on NBC's Just Shoot Me, as mail clerk Kevin Liotta. Posehn occasionally contributed as well to Comedy Central's Jerky Boys-like puppetcast Crank Yankers. A handful of big-screen roles followed, including that of a store clerk in the yuk-yuk (Jim Carrey-less) comedy sequel Dumb and Dumberer (2003), Jimmy in Rob Zombie's 2005 splatterfest The Devil's Rejects, and a spot as himself in Sarah Silverman: Jesus Is Magic. As an offshoot of Mr. Show, Posehn teamed with Bob Odenkirk and many others to co-author the script of 2002's Run Ronnie Run!, a project intended for the big screen (ala Jackass: The Movie) but disastrously reedited and all but disowned by its creators. Following The Devil's Rejects, Posehn signed on to provide a voice for helmer Mr. Lawrence's second directorial outing (which Rob Zombie scripted), 2007's animated The Haunted World of El Superbeasto. He had some prior experience, via his voice work on a number of animated series, including Mission Hill, 3 South, and several Adult Swim projects. Something of an underground, counterculture figure, Posehn -- a self-proclaimed "metal head" and comic-book devotee -- is good friends with the gifted Southern California-based comic Patton Oswalt (whom he joined on the Comedians of Comedy tour) and, more tellingly, with Anthrax's Scott Ian (with whom he collaborated on the tongue-in-cheek song, "Metal by Numbers.") Posehn has been married to comic Melanie Truhett since 2004.

Trivia: Performed in numerous local children's plays as a youth, once starring as a comedic troll in a rendering of The Hobbit. Studied improvisational comedy at iO Chicago theater. Performed improv with the Second City and Upright Citizens Brigade troupes. Worked as a nanny before her career took off. Starred opposite Joe Pesci and Don Rickles in a memorable Snickers commercial in 2012.