Trivia: First noticed by many viewers as Tim -- the Klingon-spouting "knight in training" involved with the mother of Mark (Peter Sarsgaard) in Zach Braff's gently observed comedy drama Garden State (2004) -- American actor Jim Parsons moved from this memorable debut into a sequence of periodic roles in U.S. features. These included Chris Terrio's urban ensemble drama Heights (2004), opposite Glenn Close and Elizabeth Banks, and Brad Silberling's comedy drama 10 Items or Less (2006), opposite Morgan Freeman and Paz Vega. His breakout success came when he was cast as uber-nerd Sheldon on The Big Bang Theory. His work on that show led to him scoring an Emmy win for Outstanding Lead Actor in a Comedy Series, and helped him earn small parts on the big screen in The Big Year and The Muppets.

Trivia: Name means "water" in Hebrew. Had her big break in the 1988 film Beaches, playing the younger version of Bette Midler. Appeared in the music video for Michael Jackson's "Liberian Girl." Made her television debut in the 1980s fantasy series Beauty and the Beast. Best known for her role as the title character in the sitcom Blossom. Was successful in many voiceover roles in animated series, including Kim Possible and Hey Arnold! Appeared on a 2009 episode of What Not To Wear. Her The Big Bang Theory character, Amy Farrah Fowler, is a neurobiologist, corresponding to Bialik's real-life degrees in neuroscience. Is a spokesperson for the Holistic Moms Network and gave birth to her second son at home.

Trivia: Began her career as a comedian and had a one-woman show, The Miss Education of Jenna Bush, in which she played the daughter of former president George W. Bush. Co-wrote, directed and starred in the comedic short The Condom Killer. Toured with the political-satire group Gross National Product. Performs with The Realest Real Housewives show, in which comedians read transcripts from the Real Housewives franchise. Was a recurring guest star on series 3 of The Big Bang Theory before joining the cast as a series regular in series 4.

Trivia: Actor Kunal Nayyar first made a splash in Hollywood playing physicist Koothrappali on the series The Big Bang Theory, which debuted on CBS in 2007. In 2012 Nayyar voiced the character of Gupta in Ice Age: Continental Drift, and the following year he could be seen opposite Gina Gershon and Billy Campbell in the thriller, The Scribbler. In addition to his feature work Nayyar also co-wrote the critically acclaimed play Cotton Candy, which runs in New Delhi.

Trivia: Though initially typecast in comedic roles -- including a small turn in Old School (2003), a contribution to Tracey Ullman in The Trailer Tales (2003), and work on MADtv -- American character actor Simon Helberg quickly branched out into diverse genres. He appeared as a CBS page in George Clooney's revered Edward R. Murrow biopic Good Night, and Good Luck., as a junior agent in Christopher Guest's For Your Consideration (2006), and in a recurring role on the Aaron Sorkin comedy drama Studio 60 on the Sunset Strip. In 2007, Helberg was cast in the regular role of Howard Wolowitz on the sitcom The Big Bang Theory, about a couple of nerdy physicists (Johnny Galecki and Jim Parsons) who struggle with women, and everything else outside the lab. In 2007, Helberg also made appearances in the comedies Mama's Boy and Walk Hard: The Dewey Cox Story. He played a young rabbi in the Coen brothers film A Serious Man (2009), and continued to make guest appearances on TV shows such as Kick Buttowski: Suburban Daredevil and Drunk History, while maintaining his regular status on The Big Bang Theory.

Trivia: Born on a Belgian army base, curly brown-haired Johnny Galecki grew up in Chicago and started acting professionally at the age of 12. He made his feature film debut in 1988 as River Phoenix's little brother in A Night in the Life of Jimmy Reardon. He then assumed the role of Rusty Griswold in National Lampoon's Christmas Vacation, and gained his first regular role on a TV series as Robert Ulrich's son in American Dreamer. In 1991, he starred in the made-for-TV movie Backfield in Motion, co-starring the production team of Roseanne and Tom Arnold. The next year, Galecki joined the cast of Roseanne as Darlene's sensitive and put-upon boyfriend David Healy. He stayed on the show until its final season in 1997, although he wasn't on very much during its last few years. His other television credits include several guest appearances, leading roles in made-for-TV movies, and a part on the short-lived Head of the Class spin-off Billy. After Roseanne ended, he got back into features with small parts in I Know What You Did Last Summer, Bean, and Suicide Kings. He continued playing slightly effeminate sensitive males in The Opposite of Sex and Morgan's Ferry. After bit parts in Bounce, Playing Mona Lisa, and Vanilla Sky, Galecki played a leading role in the comedy thriller Bookies, which premiered at the 2003 Sundance Film Festival. In 2007 he landed the leading role in the sitcom The Big Bang Theory and it grew to be one of the most popular shows on TV, earning Galecki Emmy, Golden Globe, and Sag nominations in 2011 for his work on the show. He maintained his movie career in projects such as Hancock and In Time.

Trivia: Kaley Cuoco began modeling and acting at the tender age of six, when she was cast in the TV movie Quicksand: No Escape. Growing up in front of the camera, the young actress continued to appear as the requisite little girl in movies like Virtuosity and Picture Perfect until she was cast as teenage daughter Bridget on the sitcom 8 Simple Rules. TV would prove to be the actor's bread and butter, and she would go on to star on Charmed, 6Teen, and Monster Allergy, not to mention The Big Bang Theory, a show that earned her legions of fans as Penny, the hot neighbor of two geeky physicists (Johnny Galecki, Jim Parsons). Cuoco also continued to appear in films, though on a much smaller scale compared to her TV work. She appeared in a supporting role in the Easter film Hop in 2011, and played the female lead opposite Kevin Hart and Josh Gad in The Wedding Ringer in 2015.

Trivia: Studied acting with Uta Hagen. Had a recurring role on The Big Bang Theory starting with its second series, and was promoted to series regular in 2012 for the sixth series. Plays the owner of a comic-book shop in The Big Bang Theory, and once worked at a similar establishment in New York City. Both of his parents are schoolteachers. Has appeared in more than 30 US adverts, including Eggos and FedEx.

Trivia: Matriculating from Illinois State University, actress Laurie Metcalf was one of the charter members of Chicago's groundbreaking Steppenwolf Theatre troupe. She moved on to New York in the early '80s, winning a 1984 Theatre World Award and an Obie for her performance in Balm in Gilead. In films since 1985, the flexible Metcalf has been seen in director Susan Seidelman's Desperately Seeking Susan (1985) and Making Mr. Right (1987), and also in several other highly regarded productions, notably Uncle Buck (1989), JFK (1991), and Mistress (1992). Metcalf is best known to the TV-watching public for her Emmy-winning portrayal of Roseanne Conner's police-officer sister, Jackie Harris, on the long-running sitcom Roseanne. In 1997, following the demise of her television series, Metcalf turned in a deliciously over-the-top performance as the tightly wound aspiring reporter Debbie Salt in Scream 2. In the decades to come, Metcalfe would find success on shows like Norm and The Big Bang Theory, as well as movies like Stop-Loss Georgia Rule. Despite her hectic schedule, Laurie Metcalf still finds time for an occasional return-to-the-womb appearance at the Steppenwolf Theatre, usually in the company of fellow Steppenwolfians John Malkovich, Gary Sinise, and/or Glenne Headly.

Trivia: The son of actor John Carradine, Keith Carradine began his own theatrical training at Colorado State University, dropping out after one semester because he felt he wasn't getting anywhere. Soon afterward, Carradine made his stage debut in the "tribal love rock musical" Hair; his brief relationship with fellow cast member Shelley Plimpton resulted in a daughter, Martha Plimpton, who grew up to become a prominent actress in her own right. Carradine's first film was 1971's McCabe and Mrs. Miller, directed by Robert Altman. Four years later, Carradine's musical composition "I'm Easy," which he performed in Altman's Nashville (1975), won an Academy Award. Carradine divested himself of his familiar movie mannerisms in the early 1990s to portray the folksy, gum-chewing title character in the Broadway hit The Will Rogers Follies. In 1995, he emulated the past screen villainy of his father and his brother, David, as the smirking antagonist of the movie melodrama The Ties That Bind. He continued to work in film and television throughout the rest of the decade, showing up in movies like A Thousand Acres (1997) and various TV series. Meanwhile, the early 2000s found Carradine as busy as ever, with a recurring role as Wild Bill Hickock (whom he had previously played in the 1995 feature WIld Bill) on HBO's popular wild west series Deadwood, as well as roles on Dexter, Dollhouse, and Damages serving well to keep him in the public eye. Always handy with a six-shooter, Carradine took aim at some particularly nasty extraterrestrials in Iron Man director Jon Favreau's sci-fi/western genre mash-up Cowboys and Aliens in 2011.

Trivia: Born March 15th, 1935, Bronx-native Judd Hirsch attended CCNY, where he majored in engineering and physics. A blossoming fascination in the theatre convinced Hirsch that his future lay in acting. He studied at the AADA and worked with a Colorado stock company before his 1966 Broadway debut in Barefoot in the Park. He spent many years at New York's Circle Repertory, where he appeared in the first-ever production of Lanford Wilson's The Hot L Baltimore. After an auspicious TV-movie bow in the well-received The Law (1974), Hirsch landed his first weekly-series assignment, playing the title character in the cop drama Delvecchio (1976-77). From 1978 to 1982, he was seen as Alex Reiger in the popular ensemble comedy Taxi, earning two Emmies in the process. While occupied with Taxi, Hirsch found time to act off-Broadway, winning an Obie award for the 1979 production Talley's Folly. In the following decade, he was honored with two Tony Awards for the Broadway efforts I'm Not Rappoport and Conversations with My Father. His post-Taxi TV series roles include Press Wyman in Detective in the House (1985) and his Golden Globe-winning turn as John Lacey in Dear John (1988-92). Judd Hirsch could also be seen playing Jeff Goldblum's father in the movie blockbuster Independence Day (1996). In 2001, Hirsch co-starred with Paul Bettany and Christopher Plummer in the multi-Award winning biopic A Beautiful Mind. The actor once again found success on the television screen in CBS' drama Numb3rs, in which he took on the role of Alan Eppes, father of FBI agent Don Eppes (Rob Morrow) and Professor Charlie Eppes (David Krumholtz). After appearing on all four seaons of Numb3rs, Hirsch took a small role in director Brett Ratner's crime comedy Tower Heist (2011).

Trivia: A versatile entertainer who first shot to fame as redheaded housewife Peg Bundy on the long-running television sitcom Married with Children, Katey Sagal has since established herself as one of the small screen's most reliable and prolific actresses.It was at the tender age of five that the talented youngster first began to show promise as a singer, and after honing her talent with years of practice, Sagal went on to perform as a Harlette opposite future superstar Bette Midler. After performing as a backup singer for the likes of Etta James, Olivia Newton-John, and Tanya Tucker in the mid-'80s, Sagal made her television debut on the Mary Tyler Moore sitcom Mary. Though that particular show didn't make it past the one-season mark, it did open up a world of opportunity for the aspiring young actress, who would subsequently earn three Golden Globe nominations as gaudily attired suburbanite Peg Bundy on the raunchy Fox Television sitcom Married with Children. A stinging satire of suburban dysfunction, Married with Children's gleefully lowbrow humor earned it as many fans as detractors over the course of the show's impressive ten-year run. When the plug was finally pulled on Married with Children in 1998, Sagal teamed with former Three's Company star John Ritter in the made-for-television romance Chance of a Lifetime before making appearances on such series as That '70s Show and Disney's animated show Recess.While performances in a number of made-for-television movies hinted at dramatic abilities that had never been tapped during her extended stint on Married with Children, it was cartoon voice-over work that would soon prove the bread and butter of her career during the millennial crossover. Despite the fact that it never achieved the popularity of The Simpsons, Matt Groening's animated sci-fi comedy series Futurama did gain a fairly devoted fan base during its four-year run, with Sagal in particular getting a fair amount of laughs in her role as voluptuous one-eyed alien Leela. In 2002, Sagal partnered with former Chance of a Lifetime star Ritter for the Emmy Award-winning sitcom 8 Simple Rules...for Dating My Teenage Daughter, though the tragic and unexpected death of star Ritter -- who collapsed on-set at the beginning of the second season -- brought the show to an untimely end in 2005. A pair of appearances on the phenomenally successful small-screen thriller Lost followed in 2005, and in 2006 Sagal traded barbs with William Shatner and James Spader on Boston Legal. She was a member of the cast of Sons of Anarchy when that show debuted in 2008, and she returned to voicing Leela on Futurama when the show began production again after a multi-year layoff.

Trivia: Designer label-clad force of nature, neurotic diva, and the owner of one of the most expansive mouths in the free world, Christine Baranski is one of the more distinctive actresses working on the stage and screen today. Known to television audiences for her portrayal of Cybill Shepard's brassy and unapologetically arrogant best friend on the sitcom Cybill, Baranski has also made a name for herself on the New York stage, where she has won a number of awards, and has worked as a character actress on a variety of films.Born in Buffalo, New York, on May 2, 1952, Baranski was influenced from a young age by her Polish grandparents, who were both actors. After studying acting at Julliard, she began working on the New York stage and on various TV shows, and made her film debut in 1982. The stage proved to be a particularly good medium for Baranski's talents; a staple of many New York productions, the actress earned Tony Awards and a number of other honors for her work in the Broadway productions of Tom Stoppard's The Real Thing and Neil Simon's Rumors. Usually cast as a supporting player onscreen, Baranski has done particularly notable work in Jeffrey (1995), in which she played a New York socialite; The Birdcage (1996), which featured her as the brassy mother of Robin Williams' grown son; and Cruel Intentions (1999), in which she did another hilarious turn as a New York socialite. In one of her rare excursions as a lead, Baranski gave a memorable performance as a struggling actress in Bowfinger (1999), sharing the screen with the likes of Steve Martin, Heather Graham, and Eddie Murphy.In 2002 Baranski appeared in the Best Picture Oscar winner Chicago, and she continued to work steadily on TV, in movies, and on stage appearing in projects as diverse as Eloise at the Plaza, Welcome to Mooseport, and the smash hit adaptation of the ABBA musical Mamma Mia! In 2009 she began work on the well-respected CBS drama series The Good Wife opposite Julianna Margulies.

Trivia: After supporting roles in such films as Blackballed: The Bobby Dukes Story and Talladega Nights: The Ballad of Ricky Bobby, Georgia-born actor Jack McBrayer found notoriety in 2006 as the naïve NBC page Kenneth on 30 Rock. That memorable, outrageous role launched McBreyer, a Second City alumnus, and led to him landing small but memorable parts in Forgetting Sarah Marshall and The Campaign. He also found steady work as a voice-over actor in projects such as Despicable Me and Wreck-It Ralph.

Trivia: Began acting in plays as a child and did theatre at university. Visited New York City while at university to interview for jobs on Wall Street, but also used the time to go on auditions. Attended the Royal Academy of Dramatic Art in London. Often portrays some type of authority figure. Was cast as a cop in Lethal Weapon 2, a commanding officer in Starship Troopers, and a state trooper in Little Miss Sunshine, amongst others. Has created several videos parodying his cop persona, including a fictional show called Cop Talk and one that pokes fun at his character in the series Breaking Bad.