Trivia: Born on a Belgian army base, curly brown-haired Johnny Galecki grew up in Chicago and started acting professionally at the age of 12. He made his feature film debut in 1988 as River Phoenix's little brother in A Night in the Life of Jimmy Reardon. He then assumed the role of Rusty Griswold in National Lampoon's Christmas Vacation, and gained his first regular role on a TV series as Robert Ulrich's son in American Dreamer. In 1991, he starred in the made-for-TV movie Backfield in Motion, co-starring the production team of Roseanne and Tom Arnold. The next year, Galecki joined the cast of Roseanne as Darlene's sensitive and put-upon boyfriend David Healy. He stayed on the show until its final season in 1997, although he wasn't on very much during its last few years. His other television credits include several guest appearances, leading roles in made-for-TV movies, and a part on the short-lived Head of the Class spin-off Billy. After Roseanne ended, he got back into features with small parts in I Know What You Did Last Summer, Bean, and Suicide Kings. He continued playing slightly effeminate sensitive males in The Opposite of Sex and Morgan's Ferry. After bit parts in Bounce, Playing Mona Lisa, and Vanilla Sky, Galecki played a leading role in the comedy thriller Bookies, which premiered at the 2003 Sundance Film Festival. In 2007 he landed the leading role in the sitcom The Big Bang Theory and it grew to be one of the most popular shows on TV, earning Galecki Emmy, Golden Globe, and Sag nominations in 2011 for his work on the show. He maintained his movie career in projects such as Hancock and In Time.

Trivia: Kaley Cuoco began modeling and acting at the tender age of six, when she was cast in the TV movie Quicksand: No Escape. Growing up in front of the camera, the young actress continued to appear as the requisite little girl in movies like Virtuosity and Picture Perfect until she was cast as teenage daughter Bridget on the sitcom 8 Simple Rules. TV would prove to be the actor's bread and butter, and she would go on to star on Charmed, 6Teen, and Monster Allergy, not to mention The Big Bang Theory, a show that earned her legions of fans as Penny, the hot neighbor of two geeky physicists (Johnny Galecki, Jim Parsons). Cuoco also continued to appear in films, though on a much smaller scale compared to her TV work. She appeared in a supporting role in the Easter film Hop in 2011, and played the female lead opposite Kevin Hart and Josh Gad in The Wedding Ringer in 2015.

Trivia: Though initially typecast in comedic roles -- including a small turn in Old School (2003), a contribution to Tracey Ullman in The Trailer Tales (2003), and work on MADtv -- American character actor Simon Helberg quickly branched out into diverse genres. He appeared as a CBS page in George Clooney's revered Edward R. Murrow biopic Good Night, and Good Luck., as a junior agent in Christopher Guest's For Your Consideration (2006), and in a recurring role on the Aaron Sorkin comedy drama Studio 60 on the Sunset Strip. In 2007, Helberg was cast in the regular role of Howard Wolowitz on the sitcom The Big Bang Theory, about a couple of nerdy physicists (Johnny Galecki and Jim Parsons) who struggle with women, and everything else outside the lab. In 2007, Helberg also made appearances in the comedies Mama's Boy and Walk Hard: The Dewey Cox Story. He played a young rabbi in the Coen brothers film A Serious Man (2009), and continued to make guest appearances on TV shows such as Kick Buttowski: Suburban Daredevil and Drunk History, while maintaining his regular status on The Big Bang Theory.

Trivia: Actor Kunal Nayyar first made a splash in Hollywood playing physicist Koothrappali on the series The Big Bang Theory, which debuted on CBS in 2007. In 2012 Nayyar voiced the character of Gupta in Ice Age: Continental Drift, and the following year he could be seen opposite Gina Gershon and Billy Campbell in the thriller, The Scribbler. In addition to his feature work Nayyar also co-wrote the critically acclaimed play Cotton Candy, which runs in New Delhi.

Trivia: Name means "water" in Hebrew. Had her big break in the 1988 film Beaches, playing the younger version of Bette Midler. Appeared in the music video for Michael Jackson's "Liberian Girl." Made her television debut in the 1980s fantasy series Beauty and the Beast. Best known for her role as the title character in the sitcom Blossom. Was successful in many voiceover roles in animated series, including Kim Possible and Hey Arnold! Appeared on a 2009 episode of What Not To Wear. Her The Big Bang Theory character, Amy Farrah Fowler, is a neurobiologist, corresponding to Bialik's real-life degrees in neuroscience. Is a spokesperson for the Holistic Moms Network and gave birth to her second son at home.

Trivia: Began her career as a comedian and had a one-woman show, The Miss Education of Jenna Bush, in which she played the daughter of former president George W. Bush. Co-wrote, directed and starred in the comedic short The Condom Killer. Toured with the political-satire group Gross National Product. Performs with The Realest Real Housewives show, in which comedians read transcripts from the Real Housewives franchise. Was a recurring guest star on series 3 of The Big Bang Theory before joining the cast as a series regular in series 4.

Trivia: Studied acting with Uta Hagen. Had a recurring role on The Big Bang Theory starting with its second series, and was promoted to series regular in 2012 for the sixth series. Plays the owner of a comic-book shop in The Big Bang Theory, and once worked at a similar establishment in New York City. Both of his parents are schoolteachers. Has appeared in more than 30 US adverts, including Eggos and FedEx.

Trivia: Actress Kathy Bates has been involved in the arts in one way or another since graduating from Southern Methodist University. Among the Memphis native's earliest jobs were a stint as a singing waitress in a Catskill resort and a sojourn as a gift shop cashier in New York's Museum of Modern Art. Bates was type-cast in character roles early on, which assured her a lot more work than the thousands of faceless ingenues in the business. Her film debut occurred with 1971's Taking Off, and she made her off-Broadway debut five years later in Vanities.For a long while, Bates made her name on the stage, only to see her roles go to other actresses in the plays' subsequent film adaptations. In 1983, she was nominated for a Tony award for her stage appearance as a garrulous would-be suicide in 'Night, Mother, a role played on screen by Sissy Spacek. She also appeared as Lenny McGrath in Beth Henley's Pulitzer Prize-winning play Crimes of the Heart, a role played on screen by Diane Keaton. And in 1987, playwright Terrence McNally wrote a part specifically tailored to Bates' talents: the much-abused waitress Frankie in Frankie and Johnny in the Clair de Lune, a role which won her an Obie award, and, following a familiar pattern, was played on screen by Michelle Pfeiffer.Bates finally got to star in a movie herself in 1990. And what a starring role it was: in Misery, she portrayed the psychotic "Number One Fan" of romance writer Paul Sheldon (James Caan), a searing performance which earned the actress an Academy Award and a Golden Globe. Appropriately enough, Hollywood screenwriters subsequently began making more room for Bates in their scripts. She worked steadily throughout the rest of the decade in films of greatly varying quality. Particular highlights included Fried Green Tomatoes (1991), A Prelude to a Kiss (1992), Dolores Claiborne (1995), Titanic (1997), and Primary Colors (1998), the latter of which featured Bates giving an Oscar and Golden Globe nominated performance as a political muckraker. Following her firey, foul-mouthed performance in that thinly veilied political biopic, Bates added a new credential to her resume, that of director. Initially taking the helm for the made-for-cable feature Dash and Lilly, Bates would subsequently direct episodes of the quirky HBO drama series Six Feet Under, simultaniously taking minor film roles before returning to more substantial roles with the CBS Hallmark Hall of Fame entry My Sister's Keeper. Roles in Love Liza and Dragonfly (both 2002) were soon to follow, and with her turn as an extroverted mother who catches the attention of Jack Nicholson in About Schmidt Bates would recieve her third Oscar nomination.She directed a number of episodes of the HBO series Six Feet Under before joining the cast in season 3 as Bettina. The next year she portrayed Queen Victoria in the big-budget remake of Around the World in 80 Days. She directed he feature Ambulance Girl in 2005. She continued to act steadily in a variety of projects including Failure to Launch, P.S. I Love You, Fred Claus, Bee Movie, and Revolutionary Road. She provided expert support for Sandra Bulock as the younger actress was winning an Oscar in The Blind Side, and Bates joined the cast of The Office in 2009. She was part of the large ensemble in 2010'ss Valentine's Day, and in 2011 starred as Gertrude Stein in Woody Allen's Oscar winning Midnight in Paris. That same year she launched her own network Drama series Harry's Law.

Trivia: Worked as a Latin teacher in a New Jersey high school before starting his career as a magician. Was a guest narrator for the Broadway production of The Rocky Horror Picture Show in 2001. In 2001, was awarded the Hefner First Amendment Award from the Playboy Foundation along with Penn Jillette for their work to defend free speech. Directed a stage production of Macbeth that toured the East Coast of the U.S. Is the co-author several New York Times best-selling books written with Penn Jillette, and is the author of When I'm Dead All This Will Be Yours. In April 2013, was honored with a star on the Hollywood Walk of Fame.